{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:09:03Z","timestamp":1785409743021,"version":"3.56.0"},"reference-count":0,"publisher":"Medical Association of Zenica-Doboj","issue":"2","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2025,8,25]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim.&amp;lt;\/strong&amp;gt; Colorectal cancer (CRC) ranks among the leading causes of cancer-related mortality worldwide, with significant incidence and mortality rates recorded in Kazakhstan. CRC poses a substantial healthcare burden, prompting investigations into novel prognostic markers.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim.&amp;lt;\/strong&amp;gt; This study investigates the prognostic significance of CD163 expression in patients with colorectal cancer.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Methods.&amp;lt;\/strong&amp;gt; This retrospective cohort study was conducted in Aktobe, Kazakhstan, utilizing tissue microarrays from 175 patients diagnosed with Tumor, Node, Metastasis (TNM) stage I&amp;amp;ndash;IV colon adenocarcinoma. CD163 expression was assessed through immunohistochemistry. Kaplan-Meier survival analysis was employed to estimate 5-year overall survival, defined as the interval from diagnosis to death or last follow-up. Cox proportional hazards models were used to evaluate the relationship between CD163 expression levels and survival outcomes.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Results.&amp;lt;\/strong&amp;gt; High CD163 expression was linked to advanced disease stage of colorectal cancer (p &amp;amp;lt; 0.001), lymphovascular invasion (p &amp;amp;lt; 0.001), perineural invasion (p &amp;amp;lt; 0.001), and Collagen I&amp;amp;gt;30%, A type (p&amp;amp;lt;0.001). CD163 infiltration was a negative prognostic factor for colorectal cancer patients, with higher risks of death in the high CD163 expression group compared to the low CD163 group (HR=5.769, 95% CI 3.194 &amp;amp;ndash; 10.42, p&amp;amp;lt;0.001).&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Conclusion.&amp;lt;\/strong&amp;gt; The findings highlight CD163 as a potential prognostic biomarker in CRC, warranting further investigation into its mechanistic role and therapeutic implications.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1848-22-02","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T12:54:52Z","timestamp":1772024092000},"page":"253-257","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic significance of CD163 expression in colorectal cancer stroma: a retrospective cohort 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