{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:32:47Z","timestamp":1785429167092,"version":"3.56.0"},"reference-count":0,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2025,8,25]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;\/strong&amp;gt; To assess whether colorectal carcinoma (CRC) survivors 5 years post-fluoropyrimidine (5-fluorouracil and capecitabine) chemotherapy (ChemT) have increased presence of subclinical coronary artery disease (CAD), lower iron and altered blood cell composition.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Methods &amp;lt;\/strong&amp;gt;This prospective, 2 year, single-center study used invasive coronary angiography to detect the presence of CAD among ChemT (N=45) and control group patients (age, gender-matched, cancer-na&amp;amp;iuml;ve (N=45). Full blood count and iron levels were compared between two groups.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Results &amp;lt;\/strong&amp;gt;Coronary angiography in 90 patients (mean age 65&amp;amp;plusmn;7 years; 60% male) identified significantly higher presence of CAD in CRC ChemT patient group compared to control: 80% vs. 55 % (p=0.013). CRC ChemT patients had lower red blood cell count (4.45&amp;amp;plusmn; 0.56 vs. 4.68&amp;amp;plusmn; 0.50 x10&amp;lt;sup&amp;gt;9&amp;lt;\/sup&amp;gt;\/L; p=0.044), platelet count (214.18&amp;amp;plusmn;50.99 vs. 251.00 &amp;amp;plusmn;156.40 x10&amp;lt;sup&amp;gt;9&amp;lt;\/sup&amp;gt;\/L; p=0.002) and white blood cell count (5.50 &amp;amp;plusmn;1.62 vs. 7.67&amp;amp;plusmn;1.72 x10&amp;lt;sup&amp;gt;9&amp;lt;\/sup&amp;gt;\/L; p=0.000)&amp;lt;strong&amp;gt;.&amp;lt;\/strong&amp;gt; Mean corpuscular hemoglobin concentration was higher in CRC ChemT patients (342.11 g\/L &amp;amp;plusmn;15.74 vs. 336.42 g\/L &amp;amp;plusmn;10.29: p=0.046), and iron deficiency was more prevalent (ChemT20.40 &amp;amp;micro;mol\/L &amp;amp;plusmn;3.891vs. control 23.37 &amp;amp;micro;mol\/L &amp;amp;plusmn;4.10: p=0.001).&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Conclusion &amp;lt;\/strong&amp;gt;Our study shows that among CRC survivors who underwent 5-FU and capecitabine therapy there is a significantly higher prevalence of CAD accompanied by long-term impairment in blood erythropoiesis.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Keywords&amp;lt;\/strong&amp;gt;: coronary artery disease, coronary angiography, erythropoiesis&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1936-22-02","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:52:42Z","timestamp":1757591562000},"source":"Crossref","is-referenced-by-count":1,"title":["Fluoropyrimidine adjuvant chemotherapy leads to long-term impact on coronary arteries, blood cell profile and iron in colorectal cancer survivors"],"prefix":"10.17392","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8927-5390","authenticated-orcid":false,"given":"Ivana","family":"Iveljic","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0474ygz28","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4956-1772","authenticated-orcid":false,"given":"Lejla","family":"Alidzanovic Nurkanovic","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0474ygz28","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-590X","authenticated-orcid":false,"given":"Alisa","family":"Krdzalic","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0474ygz28","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-6727","authenticated-orcid":false,"given":"Dunja","family":"Aksentijevic","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0574dzy90","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49509","published-online":{"date-parts":[[2025,8,25]]},"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/2242\/pdf\/download","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/2242\/pdf\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:45:31Z","timestamp":1775468731000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/520\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,8,25]]},"published-print":{"date-parts":[[2025,8,25]]}},"URL":"https:\/\/doi.org\/10.17392\/1936-22-02","archive":["Internet Archive"],"relation":{},"ISSN":["1840-2445","1840-0132"],"issn-type":[{"value":"1840-2445","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,25]]}}}