{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:58:39Z","timestamp":1785401919250,"version":"3.56.0"},"reference-count":0,"publisher":"Medical Association of Zenica-Doboj","issue":"2","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2025,8,25]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Untargeted Urinary&amp;lt;\/strong&amp;gt;&amp;lt;strong&amp;gt; Metabolomic Profile of Isolated Chest Trauma Patients.&amp;lt;\/strong&amp;gt;&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;ABSTRACT: &amp;lt;\/strong&amp;gt;&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;\/strong&amp;gt;To explore the untargeted urinary metabolomic biomarkers in isolated chest injury patients.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Methods &amp;lt;\/strong&amp;gt;It was a prospective study for 1 year period including the patients of isolated chest trauma as per inclusion criteria. Day 0, 3, and 7 urine samples from patients and day 0 sample from age matched healthy relatives were collected. Samples were prepared and gas chromatography mass spectrometry analysis was done using Agilent Technologies&amp;lt;strong&amp;gt;. &amp;lt;\/strong&amp;gt;Multivariate analyses were done using the &amp;#039;Biomarker Analysis&amp;#039; module of the MetaboAnalyst 6.0 to identify potential biomarkers associated with chest injuries.&amp;amp;nbsp; To identify the promising biomarkers with high sensitivity and specificity, exploratory multivariate (receiver operating characteristic) ROC curve analysis was used.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Results &amp;lt;\/strong&amp;gt;A total of 31 patients and 31 healthy controls were enrolled. A total of 101 metabolites were annotated. Based on ROC analyses, the top 15 potential markers (azelaic acid, glycerol, anthranilic acid, 2-palmitoylglycerol, 2-hydroxyhippuric acid, 4-hydroxybenzeneacetic acid, arachidic acid, 3-hydroxyhippuric acid, adenine, sucrose, butanedioic acid, 4-hydroxyphenyllactic acid, butanoic acid, 4-hydroxybenzoic acid and 2-hydroxybenzeneacetic acid) were identified. Selected frequencies of &amp;amp;gt;0.6% led to the selection of 9 biomarkers. It was found 66.5% predictive accuracy of the most accurate 50-feature panel of model with the AUC of 0.708 with 95% confidence interval.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; Nine metabolites (azelaic acid, glycerol, anthranilic acid, 2-palmitoylglycerol, 2-hydroxyhippuric acid, 4-hydroxybenzeneacetic acid, arachidic acid, 3-hydroxyhippuric acid and adenine) based on their selected frequencies of more than 0.6% can be considered as biomarkers in isolated chest trauma patients.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1954-22-02","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:52:48Z","timestamp":1757591568000},"page":"330-338","source":"Crossref","is-referenced-by-count":0,"title":["Untargeted Urinary Metabolomic Profile of Isolated Chest Trauma Patients."],"prefix":"10.17392","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4033-6249","authenticated-orcid":false,"given":"Irshad","family":"Ahmad","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences, Rishikesh","place":["Rishikesh,India"],"department":["Trauma Surgery & Critical Care"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Sircar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00582g326","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhur","family":"Uniyal","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05qjwb041","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehvish","family":"Mukhtar","sequence":"additional","affiliation":[{"name":"Government Medical College Anantnag","place":["Anantnag,India"],"department":["Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0258h0g75","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Sarkar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05qjwb041","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3166-1499","authenticated-orcid":false,"given":"Nilesh","family":"Jagne","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01w4gn737","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Qamar","family":"Azam","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05qjwb041","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49509","published-online":{"date-parts":[[2025,8,25]]},"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/2303\/pdf\/download","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/2303\/pdf\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:45:34Z","timestamp":1775468734000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/534\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,8,25]]},"published-print":{"date-parts":[[2025,8,25]]}},"URL":"https:\/\/doi.org\/10.17392\/1954-22-02","archive":["Internet Archive"],"relation":{},"ISSN":["1840-2445","1840-0132"],"issn-type":[{"value":"1840-2445","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,25]]}}}