{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:59:42Z","timestamp":1775473182229,"version":"3.50.1"},"reference-count":0,"publisher":"Medical Association of Zenica-Doboj","issue":"1","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2026,2,27]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;\/strong&amp;gt;Teriparatide, a synthetic analog of the active fragment of human parathyroid hormone (PTH 1&amp;amp;ndash;34), is a clinically approved anabolic treatment for osteoporosis. While its bone-forming capacity is well-documented, evidence regarding its systemic safety, particularly in relation to male reproductive health, remains limited.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim:&amp;lt;\/strong&amp;gt; This study was designed to investigate the histological consequences of prolonged teriparatide exposure on testicular architecture in adult male rats, addressing a critical gap in its toxicological profile.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; Twenty adult male albino rats were randomly allocated into two groups. The control group received subcutaneous saline (1 mL\/kg\/day), while and the treated group was administered teriparatide (10 &amp;amp;micro;g\/kg\/day) daily for 60 days. Testes were collected post-euthanasia, fixed in formalin, and processed for histological examination. Spermatogenic activity was assessed using Johnsen&amp;amp;rsquo;s scoring system, and morphometric parameters, including seminiferous tubule diameter and epithelial height, were quantified. Statistical significance was determined using the Mann&amp;amp;ndash;Whitney U test (p&amp;amp;le;0.05).&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Results &amp;lt;\/strong&amp;gt;Histological findings revealed preserved cytoarchitecture with active spermatogenesis in control testes. The teriparatide-treated group exhibited significant degenerative changes, including epithelial detachment, interstitial edema, vascular congestion, and Leydig cell necrosis. Johnsen&amp;amp;rsquo;s scores were significantly reduced in the treated group (median = 4.5; IQR=1.5) compared to controls (median = 8.0; IQR=2.0; p&amp;amp;lt;0.001). Furthermore, Seminiferous tubule diameter and epithelial height were markedly decreased in the treated animals.&amp;lt;\/p&amp;gt;\n&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Conclusion &amp;lt;\/strong&amp;gt;The findings suggest that prolonged teriparatide exposure may impair permatogenesis and alter testicular structure. Re-evaluation of its reproductive safety is warranted, particularly for males of reproductive age.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/2033-23-01","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:34:24Z","timestamp":1772184864000},"page":"156-161","source":"Crossref","is-referenced-by-count":0,"title":["Impact of daily administration of teriparatide on the  histological pattern of testicular structure in adult male rats"],"prefix":"10.17392","volume":"23","author":[{"given":"Omar","family":"Ameen","sequence":"first","affiliation":[{"name":"University of Mosul, Mosul, Iraq.","place":["Mosul,Iraq"],"department":["Department of Dental Basic Sciences."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada","family":"Taqa","sequence":"additional","affiliation":[{"name":"University of Mosul, Mosul, Iraq.","department":["Department of Dental Basic Sciences"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2026,2,27]]},"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/2595\/pdf\/download","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/2595\/pdf\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:45:42Z","timestamp":1775468742000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/616\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2,27]]},"published-print":{"date-parts":[[2026,2,27]]}},"URL":"https:\/\/doi.org\/10.17392\/2033-23-01","archive":["Internet Archive"],"relation":{},"ISSN":["1840-2445","1840-0132"],"issn-type":[{"value":"1840-2445","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}