{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:56:14Z","timestamp":1775472974384,"version":"3.50.1"},"reference-count":28,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2015,4,18]]},"abstract":"&lt;p&gt;&lt;strong&gt;Aim &lt;br \/&gt;&lt;\/strong&gt;To assess serum levels and correlation between uric acid (UA) and C-reactive protein (CRP) in acute coronary syndrome&lt;br \/&gt;(ACS) and apparently healthy individuals.&lt;br \/&gt;&lt;strong&gt;Methods&lt;br \/&gt;&lt;\/strong&gt; The cross-sectional study included 116 examinees of age 44 to 83 years, distributed in two groups: 80 ACS patients&lt;br \/&gt;including 40 with acute myocardial infarction (AMI), and 40 with unstable angina pectoris (UAP), and 36 apparently healthy (control group) individuals. Patients with ACS were hospitalized at the Cardiology Clinic, Clinical Centre Sarajevo in the period OctoberDecember 2012. Laboratory analyses were conducted by standard methods. The accepted statistical significance level was p&amp;lt;0.05.&lt;br \/&gt;&lt;strong&gt;Results&lt;br \/&gt;&lt;\/strong&gt; Serum levels of CRP and UA were higher in patients with ACS as compared to control group (p&amp;lt;0.01). The median serum&lt;br \/&gt;UA was insignificantly lower, and CRP was significantly higher in patients with AMI compared to UAP (p=0.118 and p=0.001, respectively). Both CRP and UA correlated positively in both ACS and control groups (rho=0.246; p=0.028 and rho=0.374; p=0.027). A positive correlation between serum CRP and UA was noted in patients with AMI, but negative in patients with UAP (p&amp;gt;0.05).&lt;br \/&gt;&lt;strong&gt;Conclusion&lt;br \/&gt;&lt;\/strong&gt; The correlation between CRP and UA in the patients with ACS indicates the association of oxidative stress and&lt;br \/&gt;inflammation intensity in damaged cardiomyocytes. Correlation between UA and CRP in apparently healthy individuals indicates a possible role of UA as a marker of low-grade inflammation and its potential in risk assessment in cardiovascular diseases.&lt;\/p&gt;<\/jats:p>","DOI":"10.17392\/821-15","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T12:51:43Z","timestamp":1713185503000},"source":"Crossref","is-referenced-by-count":1,"title":["Positive correlation between uric acid and C-reactive protein serum level in healthy individuals and patients with acute coronary syndrome"],"prefix":"10.17392","volume":"13","author":[{"given":"Emina","family":"Spahi\u0107","sequence":"first","affiliation":[{"name":"Primary Health Center Zenica","place":["Zenica,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabaheta","family":"Hasi\u0107","sequence":"additional","affiliation":[{"name":"School of Medicine University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Department of Medical Biochemistry"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emina","family":"Kiseljakovi\u0107","sequence":"additional","affiliation":[{"name":"School of Medicine University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Department of Medical Biochemistry"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halima","family":"Resi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Hemodialysis, Clinical Center University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmed","family":"Kuli\u0107","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2015,4,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ehj.2014.11.005","article-title":"C-reactive protein, inflammation and coronary heart disease","author":"AShrivastavaA","year":"2015","unstructured":"Shrivastava AK, Singh H V, Raizada A, Singh SK. \nC-reactive protein, inflammation and coronary heart \ndisease. The Egyptian Heart Journal 2015; 67:89-97.","journal-title":"The Egyptian Heart Journal"},{"issue":"Suppl 5","key":"ref2","first-page":"403","article-title":"Importance of determining biomarkers of myocardial necrosis in acute coronary syndrome","author":"RMatunovi\u0107R","year":"2005","unstructured":"Matunovi\u0107 R, Stojanovi\u0107 A, Mijailovi\u0107 Z, Ra\u0111en G. \nImportance of determining biomarkers of myocardi-\nal necrosis in acute coronary syndrome. Vojnosanit \nPregl 2005; 62(Suppl 5): 403-8.","journal-title":"Vojnosanit Pregl"},{"key":"ref3","first-page":"1813","article-title":"High-sensitivity C-reactive protein: Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease","author":"PRidkerP","year":"2001","unstructured":"Ridker PM. High-sensitivity C-reactive protein: \nPotential adjunct for global risk assessment in the \nprimary prevention of cardiovascular disease. Circu-\nlation 2001; 103:1813-18.","journal-title":"Circulation"},{"issue":"Suppl 6","key":"ref4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1155\/2013\/974358","article-title":"Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage","author":"RRodrigoR","year":"2013","unstructured":"Rodrigo R, Libuy M, Feli\u00fa F, Hasson D. Oxidative \nstress-related biomarkers in essential hypertension \nand ischemia-reperfusion myocardial damage. Dis \nMarkers 2013; 35(Suppl 6):773-90.","journal-title":"Dis Markers"},{"key":"ref5","article-title":"Serum concentration of uric acid and the outcome of acute coronary syndrome","author":"SCarS","year":"2012","unstructured":"Car S. Serum concentration of uric acid and the \noutcome of acute coronary syndrome. Medical Fa-\nculty, University of Zagreb; 2012; Ph. D. thesis.","journal-title":"Medical Faculty"},{"issue":"11","key":"ref6","first-page":"733","article-title":"High-sensitivity C-reactive protein as a biomarker of risk in coronary artery disease","author":"DSilvaaD","year":"2012","unstructured":"Silvaa D, Lacerda AP. High-sensitivity C-reactive \nprotein as a biomarker of risk in coronary artery di-\nsease. Rev Port Cardiol. 2012; 31(Suppl 11):733-45.","journal-title":"Rev Port Cardiol"},{"issue":"Suppl 3","key":"ref7","first-page":"499","article-title":"Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for health care professionals from the Centers for Disease Con-dicate greater intensity of oxidative stress in ACS than in control group. Under local ischemia condition and increased synthesis of oxygen radicals, UA becomes prooxidant (22-24). trol and Prevention and the American Heart Association","author":"TPearsonT","year":"2003","unstructured":"Pearson TA, Mensah GA, Alexander RW, Anderson \nJL, Cannon RO III, Criqui M. Markers of inflamma-\ntion and cardiovascular disease: application to clini-\ncal and public health practice: a statement for health \ncare professionals from the Centers for Disease Con-\ndicate greater intensity of oxidative stress in ACS \nthan in control group. Under local ischemia con-\ndition and increased synthesis of oxygen radicals, \nUA becomes prooxidant (22-24). \ntrol and Prevention and the American Heart Associa-\ntion. Circulation 2003; 107(Suppl 3):499-511.","journal-title":"Circulation"},{"issue":"Suppl 12","key":"ref8","first-page":"1183","article-title":"Distribution of serum C-reactive Protein and Its Association with Atherosclerotic Risk Factors in a Japanese Population","author":"SYamadaS","year":"2001","unstructured":"Yamada S, Gotoh T, Nakashima Y, Kayaba K, Ishi-\nkawa S, Nago N. Distribution of serum C-reactive \nProtein and Its Association with Atherosclerotic \nRisk Factors in a Japanese Population. Am J Epide-\nmiol. 2001; 153(Suppl 12):1183-9.","journal-title":"Am J Epidemiol"},{"key":"ref9","first-page":"237","article-title":"C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men. Augsburg Cohort Study, 1984 to1992","author":"WKoenigW","year":"1999","unstructured":"Koenig W, Sund M, Frohlich M, Fischer HG, L\u00f6wel \nH, D\u00f6ring A. C-Reactive protein, a sensitive mar-\nker of inflammation, predicts future risk of coronary \nheart disease in initially healthy middle-aged men. \nAugsburg Cohort Study, 1984 to1992. Circulation \n1999; 99:237-42.","journal-title":"Circulation"},{"issue":"Suppl 1","key":"ref10","first-page":"131","article-title":"Uric acid and serum antioxidant capacity: a reaction to atherosclerosis","author":"FNietoF","year":"2000","unstructured":"Nieto F, Iribarren C, Gross M, Comstock GW, Cutler \nRG. Uric acid and serum antioxidant capacity: a \nreaction to atherosclerosis. Atherosclerosis 2000; \n148(Suppl 1): 131-9.","journal-title":"Atherosclerosis"},{"issue":"Suppl 1","key":"ref11","first-page":"10","article-title":"Uric acid: a new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: the urate redox shuttle","author":"MHaydenM","year":"2004","unstructured":"Hayden MR, Tyagi SC. Uric acid: a new look at an \nold risk marker for cardiovascular disease, metabolic \nsyndrome, and type 2 diabetes mellitus: the urate re-\ndox shuttle. Nutr Metab. 2004; 19(Suppl 1):10.","journal-title":"Nutr Metab"},{"issue":"Suppl 9","key":"ref12","first-page":"1546","article-title":"Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study","author":"LNiskanenL","year":"2004","unstructured":"Niskanen LK, Laaksonen DE, Nyyssonen K, Alfthan \nG, Lakka HM, Lakka TA. Uric acid level as a risk \nfactor for cardiovascular and all-cause mortality in \nmiddle-aged men: a prospective cohort study. Arch \nIntern Med. 2004; 165(Suppl 9): 1546-51.","journal-title":"Arch Intern Med"},{"issue":"Suppl 4","key":"ref13","first-page":"407","article-title":"Vascular Endothelial Function Is Not Related to Serum Uric Acid in Healthy Adults","author":"DJalalD","year":"2012","unstructured":"Jalal D, Jablonski K, McFann K, Choncholand M, \nSeals D. Vascular Endothelial Function Is Not Re-\nlated to Serum Uric Acid in Healthy Adults. Am J \nHypertens. 2012; 25(Suppl 4):407-13.","journal-title":"Am J Hypertens"},{"issue":"Suppl 4","key":"ref14","first-page":"935","article-title":"The high UA levels with increase of CRP and inflammation in the body can contribute to progression of atherosclerotic disease. C. Franceschini Sdo C","author":"FVidigalF","year":"2014","unstructured":"Vidigal F, Rosado L, Rosado GP, Ribeiro C. The \nhigh UA levels with increase of CRP and inflamma-\ntion in the body can contribute to progression of \natherosclerotic disease. C. Franceschini Sdo C. Nutr \nHosp. 2014; 29(Suppl 4):935-40.","journal-title":"Nutr Hosp"},{"issue":"Suppl 1","key":"ref15","first-page":"21","article-title":"A study of serum uric acid and C-reactive protein in acute myocardial infarction","author":"MBaruahM","year":"2012","unstructured":"Baruah M, Nath C, Chaudhury B, Devi R, Ivvala AS. \nA study of serum uric acid and C-reactive protein in \nacute myocardial infarction. IJBMSP 2012; 2(Suppl \n1): 21-4.","journal-title":"IJBMSP"},{"issue":"Suppl 2","key":"ref16","first-page":"235","article-title":"Control of the acute phase response. Serum C-reactive protein kinetics after acute myocardial infarction","author":"IKushnerI","year":"1998","unstructured":"Kushner I, Broder M, Karp D. Control of the acute \nphase response. Serum C-reactive protein kinetics \nafter acute myocardial infarction. J Clin Invest 1998; \n61(Suppl 2): 235-42.","journal-title":"J Clin Invest"},{"key":"ref17","first-page":"250867","article-title":"Value of C-reactive protein in predicting left ventricular remodelling in patients with a first ST-segment elevation myocardial infarction","author":"ISwiatkiewiczI","year":"2012. 2012","unstructured":"Swiatkiewicz I, Kozinski M, Magielski P, Fabiszak \nT, Sukiennik A, Navarese EP, Odrowaz-Sypniewska \nG, Kubica J. Value of C-reactive protein in predic-\nting left ventricular remodelling in patients with a \nfirst ST-segment elevation myocardial infarction. \nMediators Inflamm 2012; 2012:250867.","journal-title":"Mediators Inflamm"},{"key":"ref18","first-page":"643","article-title":"High Sensitive C -reactive protein levels in patients with acute coronary syndrome. The Iraqi Postgraduate","author":"HYildizH","year":"2013","unstructured":"Yildiz HT. High Sensitive C -reactive protein levels \nin patients with acute coronary syndrome. The Iraqi \nPostgraduate Medical Journal 2013:643-9.","journal-title":"Medical Journal"},{"issue":"Suppl 2","key":"ref19","first-page":"154","article-title":"C-reactive protein and acute coronary syndrome: correlation with traditional risk factors, diagnostic cardiac biomarkers, and ejection fraction","author":"TMunirT","year":"2009","unstructured":"Munir TA, Afzal MN, Ahmed R. C-reactive protein \nand acute coronary syndrome: correlation with tra-\nditional risk factors, diagnostic cardiac biomarkers, \nand ejection fraction. RMJ. 2009; 34(Suppl 2):154-\n9.","journal-title":"RMJ"},{"key":"ref20","first-page":"96","article-title":"C-reactive protein as a cardiovascular risk factor; more than an epiphenomenon","author":"WLagrandW","year":"1999","unstructured":"Lagrand WK,Visser CA, Hermens WT, Niessen \nHWM,Verheught FWA, Wolbink GJ, et al. C-reacti-\nve protein as a cardiovascular risk factor; more than \nan epiphenomenon. Circulation 1999; 96-102.","journal-title":"Circulation"},{"issue":"Suppl 2","key":"ref21","first-page":"166","article-title":"Relation of serum uric acid levels with the presence and severity of angiographic coronary artery disease","author":"MGurM","year":"2008","unstructured":"Gur M, Yilmaz R, Demirbag R, Aksoy N. Relation \nof serum uric acid levels with the presence and seve-\nrity of angiographic coronary artery disease. Angio-\nlogy 2008; 59(Suppl 2):166-71.","journal-title":"Angiology"},{"issue":"Suppl 6","key":"ref22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.numecd.2007.02.011","article-title":"Uric acid and oxidative stress: relative impact on cardiovascular risk?","author":"PStrazzulloP","year":"2007","unstructured":"Strazzullo P, Puig JG. Uric acid and oxidative stress: \nrelative impact on cardiovascular risk? Nutr Metab \nCardiovasc Dis 2007; 17(Suppl 6):409-14.","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"Suppl 6","key":"ref23","first-page":"608","article-title":"Uric Acid: The oxidant-antioxidant paradox","author":"YSautinY","year":"2008","unstructured":"Sautin YY, Johnson YR. Uric Acid: The oxidant-an-\ntioxidant paradox. Nucleosides Nucleotides Nucleic \nAcids 2008; 27(Suppl 6):608-19.","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"issue":"Suppl 9","key":"ref24","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.amjcard.2011.12.018","article-title":"Prognostic value of uric acid in patients with acute coronary syndromes","author":"GNdrepepaG","year":"2012","unstructured":"Ndrepepa G, Braun S, Haase HU, Schulz S, Ranftl \nS, Hadamitzky M, Mehilli J, Sch\u00f6mig A, Kastrati A. \nPrognostic value of uric acid in patients with acute \ncoronary syndromes. Am J Cardiol 2012; 109(Suppl \n9):1260-5.","journal-title":"Am J Cardiol"},{"key":"ref25","first-page":"4","article-title":"Emina Spahi\u0107 1 , Sabaheta Hasi\u0107 2 , Emina Kiseljakovi\u0107 2","unstructured":"Emina Spahi\u0107 1 , Sabaheta Hasi\u0107 2 , Emina Kiseljakovi\u0107 2 , Halima Resi\u0107 3 , Mehmed Kuli\u0107 4","journal-title":"Halima Resi\u0107"},{"key":"ref26","article-title":"3 Klinika za hemodijalizu, 4 Klinika za srce i reumatizam; Klini\u010dki centar Univerziteta u Sarajevu; Bosna i Hercegovina SA\u017dETAK Cilj Ispitati serumske vrijednosti i odnos izme\u0111u mokra\u0107ne kiseline (MK) i C-reaktivnog proteina (CRP) kod naizgled zdravih osoba i kod pacijenata s akutnim koronarnim sindromom (AKS)","author":"DomZdravljaDom","unstructured":"Dom zdravlja Zenica, 2 Katedra za medicinsku biohemiju, Medicinski fakultet, Univerzitet u Sarajevu, 3 Klinika za hemodijalizu, 4 Klinika za \nsrce i reumatizam; Klini\u010dki centar Univerziteta u Sarajevu; Bosna i Hercegovina \nSA\u017dETAK \nCilj Ispitati serumske vrijednosti i odnos izme\u0111u mokra\u0107ne kiseline (MK) i C-reaktivnog proteina \n(CRP) kod naizgled zdravih osoba i kod pacijenata s akutnim koronarnim sindromom (AKS)."},{"key":"ref27","article-title":"Metode U presje\u010dnu studiju bilo je uklju\u010deno 116 ispitanika, starosne dobi izme\u0111u 44 i 83 godine, distribuiranih u dvije grupe: 80 ispitanika s AKS-om i to 40 s akutnim infarktom miokarda (AIM) i 40 s nestabilnom anginom pektoris (NAP)","unstructured":"Metode U presje\u010dnu studiju bilo je uklju\u010deno 116 ispitanika, starosne dobi izme\u0111u 44 i 83 godine, \ndistribuiranih u dvije grupe: 80 ispitanika s AKS-om i to 40 s akutnim infarktom miokarda (AIM) i 40 \ns nestabilnom anginom pektoris (NAP), te 36 naizgled zdravih ispitanika (kontrolna grupa, KG). Ispita-\nnici s AKS-om bili su hospitalizirani na Klinici za bolesti srca i reumatizam Univerzitetskog klini\u010dkog \ncentra u Sarajevu u periodu od oktobra do decembra 2012. godine. Laboratorijske analize su ura\u0111ene \nkori\u0161tenjem standardnih metoda. Prihva\u0107eni nivo statisti\u010dke zna\u010dajnosti iznosio je p<0.05. \nRezultati Vrijednosti CRP-a i MK-a u serumu bile su vi\u0161e u ispitanika s AKS-om u odnosu na KG \n(p<0.01). Vrijednost MK-a u serumu nije bila zna\u010dajno ni\u017ea, dok je vrijednost CRP-a bila zna\u010dajno \nvi\u0161a kod pacijenata s AIM-om u pore\u0111enju s pacijenatima s nestabilnom anginom pektoris (p=0.118;"},{"key":"ref28","article-title":"Zaklju\u010dak Odnos CRP-a i MG-a u serumu oboljelih od AKS-a ukazuje na povezanost intenziteta oksidativnog stresa s intenzitetom inflamacije zahva\u0107enog dijela kardiomiocita. Povezanost vrijednosti MK-a i CRP-a u serumu naizgled zdravih ispitanika ukazuje na mogu\u0107u ulogu MK-a kao markera intenziteta hroni\u010dne inflamacije niskog stepena te predstavlja potencijal u procjeni rizika za razvoj kardiovaskularnih bolesti","author":"Pozitivna","unstructured":"Pozitivna, zna\u010dajna korelacija je utvr\u0111ena izme\u0111u serumskih vrijednosti CRP-a i MK-a i kod \nispitanika s AKS-om i kod KG-a. (rho=0.246; p=0.028 i rho=0.374; p=0.027). Utvr\u0111en je pozitivan od-\nnos CRP-a i MK-a u serumu ispitanika s AIM-om, a negativan u NAP-u, ali nije bio statisti\u010dki zna\u010dajan \n(p>0.05). \nZaklju\u010dak Odnos CRP-a i MG-a u serumu oboljelih od AKS-a ukazuje na povezanost intenziteta ok-\nsidativnog stresa s intenzitetom inflamacije zahva\u0107enog dijela kardiomiocita. Povezanost vrijednosti \nMK-a i CRP-a u serumu naizgled zdravih ispitanika ukazuje na mogu\u0107u ulogu MK-a kao markera \nintenziteta hroni\u010dne inflamacije niskog stepena te predstavlja potencijal u procjeni rizika za razvoj kar-\ndiovaskularnih bolesti."}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/151\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/151\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:43:25Z","timestamp":1775468605000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/20\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,18]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,4,18]]},"published-print":{"date-parts":[[2015,4,18]]}},"URL":"https:\/\/doi.org\/10.17392\/821-15","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4,18]]}}}