{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:56:20Z","timestamp":1775472980044,"version":"3.50.1"},"reference-count":29,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; The administration of trans esophageal echocardiography (TEE) may cause nausea, shortness of breath, agitation, emotional distress and pain in patients due to pharyngo-esophageal intubation, which may be partially relieved by sedoanalgesia. The aim of this study was to compare clinical effects of midazolam, midazolam-alfentanil combination and propofol sedation given for sedation and sedoanalgesia to patients with planned diagnostic TEE&amp;lt;br \/&amp;gt;interventions.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;This study was prospectively completed with 90 randomized adult patients in ASA risk groups I-II-III. Group M were&amp;lt;br \/&amp;gt;given 2.5 mg midazolam, group MA were given 1 mg midazolam and 5 &amp;amp;mu;g\/kg alfentanil and group P were given 0.5 mg\/kg propofol intravenous bolus. If necessary, additional doses were administered. Patients administered with TEE were evaluated in terms of additional dose requirements, Ramsey Sedation Scale (RSS), modified Aldrete Scoring (MAS), recovery time and duration of stay in the hospital.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; In the group P additional dose requirements were greater (p&amp;amp;lt;0.05), as well as the duration of stay in the recovery unit and&amp;lt;br \/&amp;gt;hospital were shorter (p&amp;amp;lt;0.05). On insertion of the TEE probe, the RSS in the group P was clearly higher than in other groups M and MA (p&amp;amp;lt;0.05).&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; During the TEE intervention, the use of propofol, contrary to requirements for additional dose and observation of&amp;lt;br \/&amp;gt;apnea, appears to be advantageous due to providing more rapid and effective sedation depth without a need of expensive antagonist agents, and allowing early discharge of patients. Additionally, it seems that the use of midazolam combined with alfentanil, is more advantageous comparing to midazolam alone.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/825-16","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T12:51:43Z","timestamp":1713185503000},"page":"18-24","source":"Crossref","is-referenced-by-count":0,"title":["Sedation for transesophageal echocardiography: comparison of propofol, midazolam and midazolam-alfentanil combination"],"prefix":"10.17392","volume":"13","author":[{"given":"Toman","family":"Huseyin","sequence":"first","affiliation":[{"name":"Canakkale Onsekiz Mart University, School of Medicine","place":["Canakkale,Turkey"],"department":["Department of Anesthesiology and Reanimation"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atakan","family":"Erk\u0131l\u0131nc","sequence":"additional","affiliation":[{"name":"Clinic of Anesthesiology and Reanimation, Kartal Kosuyolu High Specialty Education and Research Hospital","place":["Istanbul,Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuncer","family":"Kocak","sequence":"additional","affiliation":[{"name":"Clinic of Anesthesiology and Reanimation, Kartal Kosuyolu High Specialty Education and Research Hospital,","place":["Istanbul,Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusun","family":"Guzelmeric","sequence":"additional","affiliation":[{"name":"Clinic of Anesthesiology and Reanimation, Kartal Kosuyolu High Specialty Education and Research Hospital","place":["Istanbul,Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Faruk Savluk","sequence":"additional","affiliation":[{"name":"Clinic of Anesthesiology and Reanimation, Kartal Kosuyolu High Specialty Education and Research Hospital","place":["Istanbul,Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mevlut","family":"Dogukan","sequence":"additional","affiliation":[{"name":"Adiyaman University Training and Research Hospital","place":["Adiyaman,Turkey"],"department":["Department of Anesthesiology and Reanimation"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goksel","family":"Acar","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital","place":["Istanbul,Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"ref1","first-page":"615","article-title":"Comparison of multiplane transesophageal echocardiography and contrast-enhancedhelical CT in the diagnosis of blunt traumatic cardiovascular injuries","author":"PVignonP","year":"2001","unstructured":"Vignon P, Boncoeur MP, Fran\u00e7ois B, Rambaud G, \nMaubon A, Gastinne H. 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A meta-analysis of the predictive accuracy of postoperative mortality using the American Society of Anesthesiologists' physical status classification system","author":"CKooC","year":"2015","unstructured":"Koo CY, Hyder JA, Wanderer JP, Eikermann M, Ra-\nmachandran SK. A meta-analysis of the predictive \naccuracy of postoperative mortality using the Ameri-\ncan Society of Anesthesiologists' physical status cla-\nssification system. World J Surg 2015; 39:88-103.","journal-title":"World J Surg"},{"key":"ref11","first-page":"860","article-title":"Assessment of the effects of ketamine-fentanyl combination versus propofol-remifentanil combination for sedation during endoscopic retrograde cholangiopancreatography","author":"SHeidariS","year":"2014","unstructured":"Heidari SM, Loghmani P. Assessment of the effects \nof ketamine-fentanyl combination versus propofol-\nremifentanil combination for sedation during endos-\ncopic retrograde cholangiopancreatography. 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New York: Lange Medical Boks\/MC Graw-\nHill Medical Publishing Division, 2002."},{"key":"ref26","year":"11 June 2015","unstructured":"Drugs. Propofol-Lipuro 1 % (10 mg\/ml) http:\/\/www. \ndrugs.com (11 June 2015)","journal-title":"Drugs. Propofol-Lipuro"},{"key":"ref27","article-title":"Midazolam Injection BP 5 mg\/ml solution for injection or infusion Summary of Product Characteristics","author":"DataFarmData","year":"25 June 2015","unstructured":"Data Farm. Emc. Midazolam Injection BP 5 mg\/ml \nsolution for injection or infusion Summary of Product \nCharacteristics \nhttp:\/\/www.medicines.org.uk\/emc\/ \nmedicine\/26596 (25 June 2015)"},{"key":"ref28","first-page":"353","article-title":"Comparison of remifentanil and fentanyl in anaesthesia for elective cardioversion","author":"FMaltepeF","year":"2006","unstructured":"Maltepe F, Kocaayan E, Ugurlu BS, Akdeniz B, \nGuneri S. Comparison of remifentanil and fentanyl in \nanaesthesia for elective cardioversion. 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Chest 1993; 104:1029-31.","journal-title":"Chest"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/340\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/340\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:43:28Z","timestamp":1775468608000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/33\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,1]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,9,1]]},"published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.17392\/825-16","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,1]]}}}