{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:16:05Z","timestamp":1792062965746,"version":"4.4.0"},"reference-count":19,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; To investigate whether there is a relation between neutrophillymphocyte (N\/L) and platelet- lymphocyte (P\/L) ratios and epicardial adipose tissue (EAT) thickness in patients with ankylosing spondylitis (AS).&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Thirty patients diagnosed with ankylosing spondylitis and 25 healthy people (controls) were included in the study. Age,&amp;lt;br \/&amp;gt;gender, body mass index (BMI), height, hemogram, sedimentation, neutrophil\/lymphocyte ratio, platelet\/lymphocyte ratio, CRP, hepatic and renal function tests, lipid profile of the all patients were recorded. Data related to duration of the disease, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) values of the cases in the patient group were obtained. A cardiologist measured EAT thickness by ECHO in both patient and control groups.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; In the patient group, mean BASDAI and BASFI scores were 2.48&amp;amp;plusmn;2.21 and 1.5&amp;amp;plusmn;2.07, respectively. Age, gender, BMI values did not show statistically significant difference between the patient and the control groups. N\/L and P\/L ratios did not change significantly in the patient group having higher EAT, BASFI values and taking anti-TNF compared to the control group.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; In patients with AS, EAT measurements, which are related to inflammatory response increase, can be used for monitoring of the risk of development of cardiac disease. We could not find the relation between EAT and N\/L, P\/L ratios in terms of&amp;lt;br \/&amp;gt;evaluation of inflammatory response.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/832-16","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T12:51:43Z","timestamp":1713185503000},"page":"14-17","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of relation between neutrophil lympocyte, platelet lympocyte ratios and epicardial fat thickness in patients with ankylosing spondylitis"],"prefix":"10.17392","volume":"13","author":[{"given":"Ismail","family":"Boyraz","sequence":"first","affiliation":[{"name":"Abant Izzet Baysal University Medical Faculty","department":["Department of Physical Medicine and Rehabilitation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabri","family":"Onur Caglar","sequence":"additional","affiliation":[{"name":"Koroglu Training and Research Hospital","department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Erdem","sequence":"additional","affiliation":[{"name":"Abant Izzet Baysal University Medical Faculty","place":["Bolu,Turkey"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Yazic","sequence":"additional","affiliation":[{"name":"Abant Izzet Baysal University Medical Faculty","place":["Bolu,Turkey"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"Yazici","sequence":"additional","affiliation":[{"name":"Abant Izzet Baysal University Medical Faculty","place":["Bolu,Turkey"],"department":["Department of Physical Medicine and Rehabilitation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunyamin","family":"Koc","sequence":"additional","affiliation":[{"name":"Abant Izzet Baysal University Medical Faculty","place":["Bolu,Turkey"],"department":["Department of Physical Medicine and Rehabilitation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Gunduz","sequence":"additional","affiliation":[{"name":"Karabuk University Medical Faculty","place":["Karabuk,Turkey"],"department":["Department of Physical Therapy and Rehabilitation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Karakoyun","sequence":"additional","affiliation":[{"name":"Aksaray State Hospital","place":["Aksaray,Turkey"],"department":["Physical Therapy and Rehabilitation of Department"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49509","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ejim.2011.06.006","article-title":"Extra-articular manifestations of ankylosing spondylitis: prevalence, characteristics and therapeutic implications","author":"ElMaghraouiEl","year":"2011","unstructured":"El Maghraoui A. Extra-articular manifestations of \nankylosing spondylitis: prevalence, characteristics \nand therapeutic implications. Eur J Intern Med 2011; \n22:554-60.","journal-title":"Eur J Intern Med"},{"key":"ref2","first-page":"1089","article-title":"Valvular and coronary heart disease in systemic inflammatory diseases: systemic disorders in heart disease","author":"CRoldanC","year":"2008","unstructured":"Roldan CA. Valvular and coronary heart disease in \nsystemic inflammatory diseases: systemic disorders \nin heart disease. Heart 2008; 94:1089-101.","journal-title":"Heart"},{"key":"ref3","first-page":"23","article-title":"Ankylosing spondylitis and cardiac abnormalities","author":"DYangD","year":"2012","unstructured":"Yang DH. Ankylosing spondylitis and cardiac abnor-\nmalities. J Cardiovasc Ultrasound 2012; 20:23-4.","journal-title":"J Cardiovasc Ultrasound"},{"key":"ref4","first-page":"325","article-title":"EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis","author":"MPetersM","year":"2010","unstructured":"Peters MJ, Symmons DP, McCarey D, Dijkmans BA, \nNicola P, Kvien TK, McInnes IB, Haentzschel H, \nGonzalez-Gay MA, Provan S, Semb A, Sidiropoulos \nP, Kitas G, Smulders YM, Soubrier M, Szekanecz Z, \nSattar N, Nurmohamed MT. EULAR evidence-based \nrecommendations for cardiovascular risk manage-\nment in patients with rheumatoid arthritis and other \nforms of inflammatory arthritis. Ann Rheum Dis \n2010; 69:325-31.","journal-title":"Ann Rheum Dis"},{"key":"ref5","first-page":"612","article-title":"Atherosclerosis and cardiovascular disease in the spondyloarthritides, particularly ankylosing spondylitis and psoriatic arthritis","author":"CPapagorasC","year":"2013","unstructured":"Papagoras C, Voulgari PV, Drosos AA. Atherosclero-\nsis and cardiovascular disease in the spondyloarthriti-\ndes, particularly ankylosing spondylitis and psoriatic \narthritis. Clin Exp Rheumatol 2013; 31:612-20.","journal-title":"Clin Exp Rheumatol"},{"key":"ref6","first-page":"I2","article-title":"Inflammation as a cardiovascular risk factor","author":"JWillersonJ","year":"2004","unstructured":"Willerson JT, Ridker PM. Inflammation as a cardio-\nvascular risk factor. Circulation 2004; 109:II2-10.","journal-title":"Circulation"},{"key":"ref7","first-page":"949","article-title":"Atherosclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosis","author":"JLekakisJ","year":"2000","unstructured":"Lekakis JP, Papamichael CM, Cimponeriu AT, \nStamatelopoulos KS, Papaioannou TG, Kanakakis \nJ, Alevizaki MK, Papapanagiotou A, Kalofoutis AT, \nStamatelopoulos SF. Atherosclerotic changes of extra-\ncoronary arteries are associated with the extent of coro-\nnary atherosclerosis. Am J Cardiol 2000; 85:949-52.","journal-title":"Am J Cardiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1253\/circj.71.536","article-title":"Echocardiographic epicardial fat thickness and coronary artery disease","author":"JJeongJ","year":"2007","unstructured":"Jeong JW, Jeong MH, Yun KH, Oh SK, Park EM, \nKim YK, Rhee SJ, Lee EM, Lee J, Yoo NJ, Kim NH, \nPark JC . Echocardiographic epicardial fat thickness \nand coronary artery disease. Circ J 2007; 71:536-9.","journal-title":"Circ J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.amjcard.2012.08.044","article-title":"Meta-analysis of the relation of echocardiographic epicardial adipose tissue thickness and the metabolic syndrome","author":"SPierdomenicoS","year":"2013","unstructured":"Pierdomenico SD, Pierdomenico AM, Cuccurullo F, \nIacobellis G. Meta-analysis of the relation of echocar-\ndiographic epicardial adipose tissue thickness and the \nmetabolic syndrome. Am J Cardiol 2013; 111:73-8.","journal-title":"Am J Cardiol"},{"key":"ref10","first-page":"130","article-title":"May neutrophil-lymphocyte and platelet-lymphocyte ratios indicate disease activity in ankylosing spondylitis?","author":"EInalE","year":"2015","unstructured":"Inal EE, Sunar I, Sarata\u015f \u015e, Ero\u011flu P, Inal S, Yener \nM. May neutrophil-lymphocyte and platelet-lymp-\nhocyte ratios indicate disease activity in ankylosing \nspondylitis? Arch Rheumatology 2015; 30:130-7.","journal-title":"Arch Rheumatology"},{"key":"ref11","first-page":"2912","article-title":"Ratio of neutrophil\/lymphocyte and platelet\/lymphocyte in patient with ankylosing spondylitis that are treating with anti-TNF","author":"IBoyrazI","year":"2014","unstructured":"Boyraz I, Ko\u00e7 B, Boyac\u0131 A, Tuto\u011flu A, Sarman H, \nOzkan H. Ratio of neutrophil\/lymphocyte and plate-\nlet\/lymphocyte in patient with ankylosing spondylitis \nthat are treating with anti-TNF. Int J Clin Exp Med \n2014; 7:2912-5.","journal-title":"Int J Clin Exp Med"},{"key":"ref12","first-page":"295","article-title":"Epicardial adipose tissue thickness in patients with ankylosing spondylitis","author":"H1ResorluH1","year":"2015","unstructured":"Resorlu H1, Akbal A, Resorlu M, Gokmen F, Ates \nC, Uysal F, Adam G, Aylanc N, Arslan M, \u0130nceer \nBS. Epicardial adipose tissue thickness in patients \nwith ankylosing spondylitis. Clin Rheumatol 2015; \n34:295-9.","journal-title":"Clin Rheumatol"},{"key":"ref13","first-page":"782850","article-title":"Epicardial fat thickness as cardiovascular risk factor and therapeutic target in patients with rheumatoid arthritis treated with biological and nonbiological therapies","author":"MLima-Mart\u00ednezM","year":"2014","unstructured":"Lima-Mart\u00ednez MM, Campo E, Salazar J, Paoli M, \nMaldonado I, Acosta C, Rodney M, Contreras M, Ca-\nbrera-Rego JO, Iacobellis G. Epicardial fat thickness \nas cardiovascular risk factor and therapeutic target \nin patients with rheumatoid arthritis treated with bi-\nological and nonbiological therapies. Arthritis 2014: \n782850."},{"key":"ref14","first-page":"2460","article-title":"Human epicardial adipose tissue is a source of inflammatory mediators","author":"TMazurekT","year":"2003","unstructured":"Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl \nJT, Arafat H, Sarov-Blat L, O'Brien S, Keiper EA, \nJohnson AG, Martin J, Goldstein BJ, Shi Y. Human \nepicardial adipose tissue is a source of inflammatory \nmediators. Circulation 2003; 108:2460-6.","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s10753-013-9675-2","article-title":"As a new inflammatory marker for familial Mediterranean fever: neutrophil-to-lymphocyte ratio","author":"AAhsenA","year":"2013","unstructured":"Ahsen A, Ulu MS, Yuksel S, Demir K, Uysal M, Er-\ndogan M, Acarturk G. As a new inflammatory marker \nfor familial Mediterranean fever: neutrophil-to-lymp-\nhocyte ratio. Inflammation 2013; 36:1357-62.","journal-title":"Inflammation"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nrrheum.2010.181","article-title":"Chronic inflammation in FMF: markers, risk factors, outcomes and therapy","author":"IBen-ZviI","year":"2011","unstructured":"Ben-Zvi I, Livneh A. Chronic inflammation in FMF: \nmarkers, risk factors, outcomes and therapy. Nat Rev \nRheumatol 2011; 7:105-12.","journal-title":"Nat Rev Rheumatol"},{"key":"ref17","first-page":"185317","article-title":"Is neutrophil\/lymphocyte ratio associated with subclinical inflammation and amyloidosis in patients with familial Mediterranean fever?","author":"AUsluA","year":"2013. 2013","unstructured":"Uslu AU, Deveci K, Korkmaz S, Aydin B, Senel S, \nSancakdar E, Sencan M. Is neutrophil\/lymphocyte \nratio associated with subclinical inflammation and \namyloidosis in patients with familial Mediterranean \nfever? Biomed Res Int 2013; 2013:185317.","journal-title":"Biomed Res Int"},{"key":"ref18","first-page":"680","article-title":"The platelet-lymphocyte ratio: A simple, inexpensive and rapid prognostic marker for cardiovascular events","author":"SBaltaS","year":"2015","unstructured":"Balta S, Ozturk C. The platelet-lymphocyte ratio: A \nsimple, inexpensive and rapid prognostic marker for \ncardiovascular events. Platelets 2015; 26:680-1.","journal-title":"Platelets"},{"key":"ref19","first-page":"318","article-title":"Familial Mediterranean fever: clinical, molecular and management advancements","author":"MLidarM","year":"2007","unstructured":"Lidar M, Livneh A. Familial Mediterranean fever: \nclinical, molecular and management advancements. \nNeth J Med 2007; 65:318-24.","journal-title":"Neth J Med"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/155\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/155\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:43:24Z","timestamp":1775468604000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/15\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,1]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,9,1]]},"published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.17392\/832-16","archive":["Internet Archive"],"relation":{"is-cited-by":[{"id-type":"doi","id":"10.1007\/s10067-022-06261-5","asserted-by":"object"}]},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,1]]}}}