{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:56:16Z","timestamp":1775472976867,"version":"3.50.1"},"reference-count":21,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;To investigate the relationship between recovered hepatitis B infection with appearance of toxic propylthiouracil (PTU) hepatitis and point out the growing importance of the use of drugs in the development of hepatitis.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;A case of a 45-year-old female patient with suspicion of acute viral hepatitis who had polypragmasy of drugs in the last ten&amp;lt;br \/&amp;gt;years, due to the polymorphism of symptoms\/illnesses (diabetes mellitus, depression, hypertension, hypothyroidism) was presented.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; A female patient had hyperthyroidism after resolved viral hepatitis B with HBsAg seroconversion (HBsAg negative, antiHBs positive). PTU had the greatest potential for hepatotoxicity of all administered drugs. After corticosteroid therapy there was a&amp;lt;br \/&amp;gt;significant improvement in liver function tests. In the course of the disease there was no change of hepatitis markers and exacerbations of hepatitis B.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; Clinical practice should comprehensively monitor the effects of the intricate and tight connection between drugs, liver&amp;lt;br \/&amp;gt;and endocrine system in order to better resolve all manifestations, complications and worsening of one or another organic system.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/885-16","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T12:51:43Z","timestamp":1713185503000},"page":"70-84","source":"Crossref","is-referenced-by-count":1,"title":["Relationship of recovered hepatitis B infection with appearance of toxic propylthiouracil hepatitis"],"prefix":"10.17392","volume":"14","author":[{"given":"Lejla","family":"\u010calki\u0107","sequence":"first","affiliation":[{"name":"Cantonal Hospital, Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["Department of Infectious Diseases"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lejla","family":"Bajramovi\u0107-Omeragi\u0107","sequence":"additional","affiliation":[{"name":"Cantonal Hospital, Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["Department of Infectious Diseases"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"ref1","first-page":"49","article-title":"Hepatitis toxica -prikaz bolesnika","author":"VKosti\u0107V","year":"2009","unstructured":"Kosti\u0107 V, Trifunovi\u0107 G, \u0110or\u0111evi\u0107 M, Jovanovi\u0107 B, \n\u0110or\u0111evi\u0107 J, Radovi\u0107 J, Popovi\u0107 L. 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Acta \nClin Belg 2015; 70:127-9.","journal-title":"Acta Clin Belg"},{"key":"ref12","first-page":"266","article-title":"Propylthiouracil-induced toxic hepatitis -report of one case","author":"WMu-CyunW","year":"2008","unstructured":"Mu-Cyun W, Wang-Sheng K, Chung-Yin C, Tai-\nSheng L, Chien-Hsing H. Propylthiouracil-induced \ntoxic hepatitis -report of one case. J Intern Med \nTaiwan 2008; 19:266-9.","journal-title":"J Intern Med Taiwan"},{"key":"ref13","article-title":"U\u010destalo uzimanje lijekova kao \u010dimbenik rizika za bolesti jetre","year":"20 August 2013","unstructured":"U\u010destalo uzimanje lijekova kao \u010dimbenik rizika za \nbolesti jetre. http:\/\/www.plivamed.net\/aktualno\/cla-\nnak\/2843 (20 August 2013)."},{"key":"ref14","first-page":"331","article-title":"Propylthiouracil hepatitis: report of a case and extensive review of the literature","author":"EMemiE","year":"2012","unstructured":"Memi E, Karras S, Tzotzas T, Krassas GE. Propylt-\nhiouracil hepatitis: report of a case and extensive \nreview of the literature. J Pediatr Endocrinol Metab \n2012; 25:331-43.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref15","first-page":"278","article-title":"Analysis of 90 cases of antithyroid drug-induced severe hepatotoxicity over 13 years in China","author":"JYangJ","year":"2015","unstructured":"Yang J, Li LF, Xu Q, Zhang J, Weng WW, Zhu \nYJ, Dong MJ. Analysis of 90 cases of antithyroid \ndrug-induced severe hepatotoxicity over 13 years in \nChina. Thyroid 2015; 25:278-83.","journal-title":"Thyroid"},{"key":"ref16","first-page":"910636","article-title":"Propylthiouracil-induced acute liver failure: role of liver transplantation","author":"ACarrionA","year":"2010. 2010","unstructured":"Carrion AF, Czul F, Arosemena LR, Selvaggi G, \nGarcia MT, Tekin A, Tzakis AG, Martin P, Ghanta \nRK. Propylthiouracil-induced acute liver failure: \nrole of liver transplantation. 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Liver abnormalities and endocrine diseases. \nBest Pract Res Clin Gastroenterol 2013; 27:553-63.","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"ref20","article-title":"Povezanost prebolovanog hepatitisa B s nastankom toksi\u010dnog hepatitisa uzrokovanog propiltiouracilom Lejla \u010calki\u0107, Lejla Bajramovi\u0107-Omeragi\u0107 Slu\u017eba za zarazne bolesti, Kantonalna bolnica Zenica SA\u017dETAK Cilj Istra\u017eiti odnos izme\u0111u toksi\u010dnog hepatitisa uzrokovanog propiltiouracilom (PTU) i prebolovanog hepatitisa B, te ukazati na sve ve\u0107i zna\u010daj upotrebe lijekova u nastanku hepatitisa. Metode Prikazan je slu\u010daj 45-godi\u0161nje bolesnice koja je, u zadnjih desetak godina","unstructured":"Povezanost prebolovanog hepatitisa B s nastankom toksi\u010dnog \nhepatitisa uzrokovanog propiltiouracilom \nLejla \u010calki\u0107, Lejla Bajramovi\u0107-Omeragi\u0107 \nSlu\u017eba za zarazne bolesti, Kantonalna bolnica Zenica \nSA\u017dETAK \nCilj Istra\u017eiti odnos izme\u0111u toksi\u010dnog hepatitisa uzrokovanog propiltiouracilom (PTU) i prebolovanog \nhepatitisa B, te ukazati na sve ve\u0107i zna\u010daj upotrebe lijekova u nastanku hepatitisa. \nMetode Prikazan je slu\u010daj 45-godi\u0161nje bolesnice koja je, u zadnjih desetak godina, imala pravu poli-\npragmaziju lijekova zbog polimorfizma tegoba (diabetes melitus, depresija, hipertenzija, hipertireoza)."},{"key":"ref21","article-title":"Najve\u0107i potencijal za hepatotoksi\u010dnost od svih ordiniranih lijekova imao je PTU. Nakon kortikosteroidne terapije do\u0161lo je do znatnog pobolj\u0161anja jetrenih testova. U toku bolesti nije do\u0161lo do promjene hepatitis-markera i egzacerbacije hepatitisa B. Zaklju\u010dak Klini\u010dka praksa mora cjelovito pratiti u\u010dinke zamr\u0161ene i uske povezanosti lijekova, jetre i endokrinog sistema, kako bi bolje rije\u0161ila sve manifestacije, komplikacije i pogor\u0161anje jednog ili drugog organskog sistema","unstructured":"Rezultati Hipertireozu je dobila nakon prebolovanog virusnog hepatitisa B sa HBsAg serokonverzijom \n(HBsAg negativan, antiHBs pozitivan). Najve\u0107i potencijal za hepatotoksi\u010dnost od svih ordiniranih lije-\nkova imao je PTU. Nakon kortikosteroidne terapije do\u0161lo je do znatnog pobolj\u0161anja jetrenih testova. U \ntoku bolesti nije do\u0161lo do promjene hepatitis-markera i egzacerbacije hepatitisa B. \nZaklju\u010dak Klini\u010dka praksa mora cjelovito pratiti u\u010dinke zamr\u0161ene i uske povezanosti lijekova, jetre i \nendokrinog sistema, kako bi bolje rije\u0161ila sve manifestacije, komplikacije i pogor\u0161anje jednog ili drugog \norganskog sistema. \nKlju\u010dne rije\u010di: lijekovi, hepatotoksi\u010dnost, hipertireoza, HBsAg serokonverzija"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/348\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/348\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:43:25Z","timestamp":1775468605000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/19\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,2,1]]},"published-print":{"date-parts":[[2017,2,1]]}},"URL":"https:\/\/doi.org\/10.17392\/885-16","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12,1]]}}}