{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:01:54Z","timestamp":1784757714599,"version":"3.55.0"},"reference-count":0,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MG"],"accepted":{"date-parts":[[2026,6,9]]},"abstract":"<jats:p>Aim: To evaluate the association between intravaginal therapy with carboxymethyl-\u03b2-glucan (CMBG) and polycarbophil and cytological regression of atypical squamous cells of undetermined significance (ASCUS) and cervical intraepithelial neoplasia grade 1 (CIN 1), compared with standard follow-up.\nMethods: This prospective observational controlled study included 80 women aged 23\u201349 years with ASCUS or CIN 1. Forty patients received intravaginal CMBG\/polycarbophil spray, and 40 were managed with standard follow-up. Allocation was based on clinical assessment and therapy availability, without randomisation. The primary outcome was cytological normalisation after 12 months, based on Papanicolaou smear results.\nResults: After 12 months, abnormal cytology was observed in 4 (10.0%) patients in the treatment group and 18 (45.0%) in the control group (RR 0.22; 95% CI 0.08\u20130.60; p&amp;lt;0.001). Normal cytology was observed in 36 (90.0%) and 22 (55.0%) patients, respectively (p&amp;lt;0.001). Human papillomavirus (HPV) persistence was detected in 2 (5.0%) patients in the treatment group and 5 (12.5%) in the control group (p=0.432).\nConclusion: Intravaginal CMBG\/polycarbophil therapy was associated with a higher rate of cytological normalisation than standard follow-up in women with ASCUS and CIN 1.\u00a0<\/jats:p>","DOI":"10.17392\/medglas-2174-23-2","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:22:24Z","timestamp":1784755344000},"source":"Crossref","is-referenced-by-count":0,"title":["Local carboxymethyl-\u03b2-glucan and polycarbophil therapy is associated with regression of low-grade cervical cytological abnormalities: a prospective observational study"],"prefix":"10.17392","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6305-3592","authenticated-orcid":false,"given":"Melika","family":"Dervi\u0161efendi\u0107 Peljto","sequence":"first","affiliation":[{"name":"Primary Health Care Centre Gra\u010danica, Gra\u010danica, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahira","family":"Jahi\u0107","sequence":"additional","affiliation":[{"name":"Gynaecological Centre \u201cDr. Mahira Jahi\u0107\u201d, Tuzla, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49509","published-online":{"date-parts":[[2026,7,22]]},"container-title":["Medicinski glasnik"],"original-title":[],"link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/680\/galley\/671\/download\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:22:25Z","timestamp":1784755345000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/680\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6,17]]}},"URL":"https:\/\/doi.org\/10.17392\/medglas-2174-23-2","relation":{},"ISSN":["1840-0132","1840-2445"],"issn-type":[{"value":"1840-0132","type":"print"},{"value":"1840-2445","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"680"}}