{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:01:04Z","timestamp":1785495664479,"version":"3.56.0"},"reference-count":0,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MG"],"accepted":{"date-parts":[[2026,7,14]]},"abstract":"<jats:p>Aim: To evaluate the effects of topical Centella asiatica extract gel on early healing of diabetic excision wounds.\nMethods: A randomised, post-test-only in vivo experiment included 28 male Wistar rats with nicotinamide\/streptozotocin-induced diabetes and dorsal excision wounds. Rats were assigned to base gel, 0.1% gentamicin, 10% C. asiatica gel, or 20% C. asiatica gel (n = 7 per group) for seven days. Epithelial thickness, fibroblast counts, collagen deposition, angiogenesis, inflammation score, and serum C-reactive protein (CRP) were assessed on day eight. Data were analysed using one-way analysis of variance with post hoc testing and Holm adjustment.\nResults: Between-group differences were significant for epithelial thickness (p = 0.044), fibroblast counts (p = 0.020), CRP levels (p = 0.002), collagen deposition (p = 0.007), angiogenesis (p &amp;lt; 0.001), and inflammation score (p = 0.009), and all remained significant after Holm adjustment. The 10% C. asiatica gel group showed the highest epithelial thickness, fibroblast count, and collagen deposition, whereas the 20% C. asiatica gel group showed the lowest CRP level and inflammation score and the highest angiogenesis level.\nConclusion: Topical C. asiatica gel was associated with favourable changes in selected early histological repair and inflammatory parameters in diabetic excision wounds. The different patterns observed with the 10% and 20% formulations should be interpreted descriptively rather than as evidence of dose-response superiority.<\/jats:p>","DOI":"10.17392\/medglas-2181-23-2","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:44:58Z","timestamp":1785494698000},"source":"Crossref","is-referenced-by-count":0,"title":["Topical &lt;em&gt;Centella asiatica&lt;\/em&gt; gel enhances tissue repair and attenuates inflammation in diabetic wounds: an experimental study in male Wistar rats"],"prefix":"10.17392","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7194-2359","authenticated-orcid":false,"given":"Eko","family":"Setiawan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015hejj83","id-type":"ROR","asserted-by":"publisher"}],"name":"Sultan Agung Islamic University"},{"id":[{"id":"https:\/\/ror.org\/015hejj83","id-type":"ROR","asserted-by":"publisher"}],"name":"Sultan Agung Islamic University"},{"id":[{"id":"https:\/\/ror.org\/015hejj83","id-type":"ROR","asserted-by":"publisher"}],"name":"Sultan Agung Islamic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9939-7529","authenticated-orcid":false,"given":"Dimas Irfan","family":"Nabih","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015hejj83","id-type":"ROR","asserted-by":"publisher"}],"name":"Sultan Agung Islamic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9976-3743","authenticated-orcid":false,"given":"Farhan Arifendy","family":"Rahman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015hejj83","id-type":"ROR","asserted-by":"publisher"}],"name":"Sultan Agung Islamic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1832-5855","authenticated-orcid":false,"given":"Hasan","family":"Syarief","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015hejj83","id-type":"ROR","asserted-by":"publisher"}],"name":"Sultan Agung Islamic University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49509","published-online":{"date-parts":[[2026,7,31]]},"container-title":["Medicinski glasnik"],"original-title":[],"link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/799\/galley\/683\/download\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:44:59Z","timestamp":1785494699000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/799\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6,17]]}},"URL":"https:\/\/doi.org\/10.17392\/medglas-2181-23-2","relation":{},"ISSN":["1840-0132","1840-2445"],"issn-type":[{"value":"1840-0132","type":"print"},{"value":"1840-2445","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"article-number":"799"}}