{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:26:24Z","timestamp":1786123584256,"version":"build-2736575974"},"reference-count":0,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MG"],"accepted":{"date-parts":[[2026,1,9]]},"abstract":"<jats:p>Aim: To investigate the relationship between coronary artery calcium (CAC) score and left ventricular global longitudinal strain (LV GLS) in patients with arterial hypertension who had a negative treadmill exercise stress test but mild to intermediate coronary stenosis on coronary computed tomography angiography (CCTA).\nMethods: A total of 53 hypertensive patients (mean age 54.8 \u00b1 4.8 years; 50.9% male) with 30\u201350% coronary stenosis on CCTA were included. Patients with diabetes, malignancy, or established coronary\/peripheral artery disease were excluded. CAC score, left ventricular ejection fraction (LVEF, Simpson\u2019s method), and LV GLS (speckle-tracking echocardiography) were measured. Groups were stratified by GLS (&amp;lt; 18.5% vs. \u2265 18.5%) and LVEF (&amp;lt; 60% vs. \u2265 60%), and CAC score differences were assessed using the Mann\u2013Whitney U test.\u00a0\nResults: The median CAC score was 27 (IQR 16\u201344.5), median LVEF 60% (IQR 58\u201363%), and mean GLS 19.37 \u00b1 0.89%. No overall association was found between CAC score and LV function by LVEF or GLS. In patients with left anterior descending (LAD) stenosis (30\u201350%), reduced LV function was linked to significantly higher CAC score. Median CAC score was higher in patients with GLS \u2264 18.5% (157 vs. 44.5; p = 0.019) and LVEF &amp;lt;60% (157 vs. 44.5; p = 0.019). No significant associations were found in right coronary artery (RCA), circumflex artery (Cx), or three-vessel stenosis subgroups.\nConclusion: Higher CAC score in hypertensive patients with mild LAD stenosis and negative stress testing identify those at risk of subclinical LV dysfunction.\u00a0<\/jats:p>","DOI":"10.17392\/medglas-2199-23-2","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:51:42Z","timestamp":1786117902000},"source":"Crossref","is-referenced-by-count":0,"title":["Subclinical systolic left ventricular dysfunction in patients with non-significant coronary artery stenosis detected by coronary computed tomography (CT) angiography"],"prefix":"10.17392","volume":"23","author":[{"given":"Edin","family":"Begic","sequence":"first","affiliation":[{"name":"Internal Medicine Department, General Hospital \"Prim. Dr. Abdulah Naka\u0161\", Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Djozic","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, General Hospital \"Prim. Dr. Abdulah Naka\u0161\", Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3299-6899","authenticated-orcid":false,"given":"Nejra","family":"Mlaco-Vrazalic","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, General Hospital \"Prim. Dr. Abdulah Naka\u0161\", Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emina","family":"Nesimi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, General Hospital \"Prim. Dr. Abdulah Naka\u0161\", Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1907-9017","authenticated-orcid":false,"given":"Akif","family":"Mla\u010do","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Stanetic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Kovacevic-Preradovic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miodrag","family":"Ostojic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49509","published-online":{"date-parts":[[2026,8,7]]},"container-title":["Medicinski glasnik"],"original-title":[],"link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/645\/galley\/702\/download\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:51:42Z","timestamp":1786117902000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/645\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6,17]]}},"URL":"https:\/\/doi.org\/10.17392\/medglas-2199-23-2","relation":{},"ISSN":["1840-0132","1840-2445"],"issn-type":[{"value":"1840-0132","type":"print"},{"value":"1840-2445","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"article-number":"645"}}