{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:29:20Z","timestamp":1747200560030,"version":"3.40.5"},"reference-count":60,"publisher":"Institute of Sensory Organs","issue":"3","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/pl\/deed.en"},{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/pl\/deed.en"},{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/pl\/deed.en"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hear Sci"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>According to the World Health Organization (WHO), by 2050 at least 700 million people will need access to hearing care and hearing rehabilitation services. The search for cell or gene therapies has been intensifying, and stem cell therapy looks a promising candidate to support hearing regeneration and reduce these numbers. The aim of this study is to provide an overview of current advances in stem cellbased therapies for cochlear hair cell regeneration and the processes being developed for future applicability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Identification and review of all articles in the databases PubMed, Web of Science, and PLoS One using the terms &lt;i&gt;stem cell&lt;\/i&gt;, &lt;i&gt;auditory hair cell regeneration&lt;\/i&gt;, and &lt;i&gt;mammalian&lt;\/i&gt; during February 2023 and following the PRISMA guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>50 articles were obtained, published between 2003 and 2022 and were systematically analyzed. The current research quantity is limited and further studies are needed, particularly in human tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The simultaneous use of cell therapy and gene therapy may lead to more promising results. Moreover, advances in cochlear hair cell regeneration with stem cells suggest there is a realistic potential to make the technique a useful future therapy.<\/jats:p><\/jats:sec>","DOI":"10.17430\/jhs\/191685","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T07:47:22Z","timestamp":1725868042000},"page":"19-36","source":"Crossref","is-referenced-by-count":0,"title":["COCHLEAR HAIR CELL REGENERATION BASED ON STEM CELLS: A SYSTEMATIC REVIEW"],"prefix":"10.17430","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3824-9607","authenticated-orcid":false,"given":"V\u00edtor Bruno","family":"Costa","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1824-1019","authenticated-orcid":false,"given":"David","family":"Tom\u00e9","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6964-5064","authenticated-orcid":false,"given":"Zeynep Ya\u011fmur","family":"\u00c7irtlik","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6244-0500","authenticated-orcid":false,"given":"Yaren","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0453-1151","authenticated-orcid":false,"given":"Filomena","family":"Clem\u00eancio","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0958-771X","authenticated-orcid":false,"given":"Theresa","family":"Pitt-Byrne","sequence":"additional","affiliation":[]}],"member":"28548","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"ref-1248590","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119149"},{"key":"ref-1248591","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-017-0467-0"},{"key":"ref-1248592","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v12.i6.422"},{"key":"ref-1248593","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2022.103736"},{"key":"ref-1248594","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2019.04.006"},{"key":"ref-1248595","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2006.15.449"},{"key":"ref-1248596","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.05.008"},{"key":"ref-1248597","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2014.07.009"},{"key":"ref-1248598","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071813-105108"},{"key":"ref-1248599","unstructured":"Monteiro L, Subtil J. Audiologia, som e audi\u00e7\u00e3o das bases \u00e0 cl\u00ednica. 1st ed. Queluz, Portugal: C\u00edrculo M\u00e9dico; 2018."},{"key":"ref-1248600","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-006-0058-3"},{"key":"ref-1248601","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/11\/6\/065001"},{"key":"ref-1248602","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-023-01130-w"},{"key":"ref-1248603","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"ref-1248604","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151526"},{"key":"ref-1248605","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.16"},{"key":"ref-1248606","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.292"},{"key":"ref-1248607","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.728583"},{"key":"ref-1248608","doi-asserted-by":"crossref","unstructured":"Roccio M, Senn P, Heller S. Novel insights into inner ear development and regeneration for targeted hearing loss therapies. Hear Res, 2019; 397: 107859. https:\/\/doi.org\/doi.org\/10.1016\/j.heares.2019.107859.","DOI":"10.1016\/j.heares.2019.107859"},{"key":"ref-1248609","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.117.300447"},{"key":"ref-1248610","doi-asserted-by":"crossref","unstructured":"Waqas M, Us-Salam I, Bibi Z, Wang Y, Li H, Zhu Z, et al. Stem cell-based therapeutic approaches to restore sensorineural hearing loss in mammals. Neural Plast, 2020; 8829660. https:\/\/doi.org\/doi.org\/10.1155\/2020\/8829660.","DOI":"10.1155\/2020\/8829660"},{"key":"ref-1248611","doi-asserted-by":"publisher","DOI":"10.1177\/1084713812440336"},{"key":"ref-1248612","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.10.001"},{"key":"ref-1248613","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4533"},{"key":"ref-1248614","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2011\/10-0149"},{"key":"ref-1248615","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.12.014"},{"key":"ref-1248616","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.072372rm"},{"key":"ref-1248617","doi-asserted-by":"publisher","DOI":"10.2217\/rme.13.32"},{"key":"ref-1248618","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-6123-4_10"},{"key":"ref-1248619","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134406"},{"key":"ref-1248620","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8419493"},{"key":"ref-1248621","doi-asserted-by":"publisher","DOI":"10.5935\/0946-5448.20170023"},{"key":"ref-1248622","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0967-1"},{"key":"ref-1248623","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2018.06.008"},{"key":"ref-1248624","doi-asserted-by":"publisher","DOI":"10.2174\/138945010791320836"},{"key":"ref-1248625","unstructured":"Zhang S, Qiang R, Dong Y, Zhang Y, Chen Y, Zhou H, et al. Hair cell regeneration from inner ear progenitors in the mammalian cochlea. Am J Stem Cells, 2020; 9(3): 25\u201335."},{"key":"ref-1248626","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"ref-1248627","doi-asserted-by":"publisher","DOI":"10.1242\/dev.177188"},{"key":"ref-1248628","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2017.04.008"},{"key":"ref-1248629","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9506387"},{"key":"ref-1248630","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8137614"},{"key":"ref-1248631","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0274"},{"key":"ref-1248632","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.5820"},{"key":"ref-1248633","doi-asserted-by":"crossref","unstructured":"Gunewardene N, Dottori M, Nayagam B. The convergence of cochlear implantation with induced pluripotent stem cell therapy. Stem Cell Rev, 2010; 8: 741\u201354.","DOI":"10.1007\/s12015-011-9320-0"},{"key":"ref-1248634","doi-asserted-by":"publisher","DOI":"10.3727\/096368908786092685"},{"key":"ref-1248635","unstructured":"Pauley S, Kopecky B, Beisel K, Soukup G, Fritzsch B. Stem cells and molecular strategies to restore hearing. Panminerva Med, 2008; 50(1): 41\u201353."},{"key":"ref-1248636","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2311"},{"key":"ref-1248637","unstructured":"Vlastarakos P, Nikolopoulos T, Tavoulari E, Kiprouli C, Ferekidis E. Novel approaches to treating sensorineural hearing loss. Auditory genetics and necessary factors for stem cell transplant. Med Sci Monit Basic Res, 2008; 14(8): 114\u201325."},{"key":"ref-1248638","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.08.023"},{"key":"ref-1248639","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Schier H. Regeneration: did you hear the news? Curr Biol, 2004; 14(3): 127\u20138.","DOI":"10.1016\/S0960-9822(04)00037-5"},{"key":"ref-1248640","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00236"},{"key":"ref-1248641","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049593"},{"key":"ref-1248642","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2020.09.022"},{"key":"ref-1248643","doi-asserted-by":"publisher","DOI":"10.14670\/HH-26.923"},{"key":"ref-1248644","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3346"},{"key":"ref-1248645","doi-asserted-by":"publisher","DOI":"10.1159\/000075998"},{"key":"ref-1248646","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12310"},{"key":"ref-1248647","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.760422"},{"key":"ref-1248648","doi-asserted-by":"publisher","DOI":"10.1097\/moo.0000000000000741"},{"key":"ref-1248649","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.12.018"}],"container-title":["Journal of Hearing Science"],"original-title":[],"link":[{"URL":"https:\/\/www.journalofhearingscience.com\/pdf-191685-113761","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.journalofhearingscience.com\/pdf-191685-113761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T07:47:38Z","timestamp":1725868058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.journalofhearingscience.com\/COCHLEAR-HAIR-CELL-REGENERATION-BASED-ON-STEM-CELLS-A-SYSTEMATIC-REVIEW,191685,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"alternative-id":["191685"],"URL":"https:\/\/doi.org\/10.17430\/jhs\/191685","relation":{},"ISSN":["2083-389X","2084-3127"],"issn-type":[{"type":"print","value":"2083-389X"},{"type":"electronic","value":"2084-3127"}],"subject":[],"published":{"date-parts":[[2024,9,5]]}}}