{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:23:56Z","timestamp":1776914636663,"version":"3.51.2"},"reference-count":26,"publisher":"MRE Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>Objectives: Tuberous sclerosis complex (TSC) is a multisystem genetic disorder characterized by the development of benign tumors. The aim of the study was to assess the prevalence of oral lesions in patients with TSC and healthy individuals. Study design: The study included 120 patients aged 1.1 to 42.7 years: 60 patients with TSC and 60 controls. Clinical assessment of oral hygiene (Plaque Index\u2013PLI), gingiva (Gingival Index\u2013GI, Gingival Overgrowth Index\u2013GOI), oral mucosa and dentition (caries, tooth wear, enamel defects) was performed. Statistical analysis was performed. Results: 40 patients with TSC received anticonvulsants. Neglected hygiene (PLI: 1.50\u00b10.96 vs 0.92\u00b10.72), gingival hyperplasia (50.0% vs.1.7%), gingivitis (80.7% vs. 53.4%), oral mucosal fibromas (10.0% vs. 0.0%), mucous membrane traumatic lesions (11.7% vs. 1.7%), enamel pits and hypoplasia of incisal borders (41.7% vs. 6.7%), tooth wear (35.0% vs. 11.7%) were more common in patients with TSC compared to controls; increased gingival hyperplasia was correlated with vigabatrin and levetiracetam treatment (r = 0.266 and 0.279, respectively), gingivitis was correlated with PLI (r= 0.635). Conclusions: Although gingival fibromas in TSC are independent of patient\u2019s age, young age, anticonvulsant therapy and local factors increase their severity. Enamel defects in TSC include pits, but also enamel loss on the incisal edges and tooth wear.<\/jats:p>","DOI":"10.17796\/1053-4625-44.3.10","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T20:16:48Z","timestamp":1594325808000},"page":"190-195","source":"Crossref","is-referenced-by-count":3,"title":["Oral Findings in Children, Adolescents and Adults with Tuberous Sclerosis Complex"],"prefix":"10.22514","volume":"44","author":[{"given":"Emil","family":"Korporowicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Olczak-Kowalczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Lipiec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"S\u0142owi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Gozdowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergiusz","family":"J\u00f3\u017awiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26027","reference":[{"key":"p_1","volume-title":"Stwardnienie guzowate: post\u0119py w diagnostyce i leczeniu. Neurol Dziec;17,33:11-22","author":"Doma\u0144ska-Pakiela D","year":"2008"},{"key":"p_2","volume-title":"Oral findings in 58 adults with tuberous sclerosis complex. J Am Acad Dermatol.;56:786-790","author":"Sparling JD","year":"2007"},{"key":"p_3","volume-title":"Gingival enlargement as a manifestation of tuberous sclerosis: case report and periodontal management. J Periodontol ;79:759-763","author":"Korol UB","year":"2008"},{"key":"p_4","volume-title":"Clinical and radiological findings related to tuberous sclerosis complex: a case report. J Contemp Dent Pract;9:85-91","author":"Gupta S","year":"2008"},{"key":"p_5","volume-title":"Oral lesions in tuberous sclerosis. J Indian Acad Oral Med Radiol ;30:189-192","author":"Reddy LS","year":"2018"},{"key":"p_6","volume-title":"Tuberous sclerosis with oral manifestations: A rare case report. Int J Appl Basic Med Res;6:60-62","author":"Sodhi S","year":"2016"},{"key":"p_7","volume-title":"Tuberous sclerosis complex: A case report and literature review. Ind J Clin Exp Ophthalmol;4(3):290-293","author":"Ali A","year":"2018"},{"key":"p_8","volume-title":"Oral health management implications in patients with tuberous sclerosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.;89:430-435","author":"Cutando A","year":"2000"},{"key":"p_9","volume-title":"Maia LC, Primo LG. Oral findings in a family with Tuberous sclerosis complex. Spec Care Dentist;35(5):261-265.","author":"Ammari MM","year":"2015"},{"key":"p_10","volume-title":"Al Mughery AS. Pitted enamel hypoplasia in tuberous sclerosis. Clinical Genetics;42:50-52","author":"Sampson JR","year":"1992"},{"key":"p_12","volume-title":"J Periodontol;38:610-616.","author":"Loe H.","year":"1967"},{"key":"p_13","volume-title":"Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. Oral Surg Oral Med Oral Pathol ;64(3):293-297","author":"McGaw T","year":"1987"},{"key":"p_15","volume-title":"Oral Health Surveys-Basic Methods","year":"2013","edition":"5"},{"key":"p_18","volume-title":"Tuberous sclerosis complex: A case report. Contemp Clin Dent","author":"Sarkar S","year":"2016"},{"key":"p_19","volume-title":"Drug-induced gingival overgrowth: old problem, new problem. Crit Rev Oral Biol Med.;2(1):103-137","author":"Hassell TM","year":"1991"},{"key":"p_20","volume-title":"Valproate-induced stomatitis. Neurology ;31:329-331","author":"Russo L.","year":"1981"},{"key":"p_21","volume-title":"Clinical and histopathological description of a new case of vigabatrin-induced gingival overgrowth. Med Oral ;5(2):133-137","author":"Mesa FL","year":"2000"},{"key":"p_22","volume-title":"Prevalence and risk of gingival overgrowth in patients treated with diltiazem or verapamil. J Clin Periodontol;32(3):294-298","author":"Miranda J","year":"2005"},{"key":"p_23","volume-title":"Cytokine levels in gingival crevicular fluid of erupting primary teeth correlated with systemic disturbances accompanying teething. Pediatr Dent ;25(5):441-448","author":"Shapira J","year":"2003"},{"key":"p_24","volume-title":"Plasma TGF-\u03b21 as a risk factor for gingival overgrowth. J Clin Periodontol ;31(10):863-868","author":"Ellis JS","year":"2004"},{"key":"p_25","volume-title":"Tuberous sclerosis complex with oral manifestations: A case report and literature review. Med Oral Patol Oral Cir Bucal","author":"Harutunian K","year":"2011"},{"key":"p_26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5005\/jcdp-6-3-30","volume":"6","author":"Bataineh A","year":"2005","journal-title":"J Contemp Dent Pract."},{"key":"p_27","volume-title":"Assessment of oral side effects of Antiepileptic drugs and traumatic oro-facial injuries encountered in Epileptic children. J Int Oral Health","author":"Ghafoor PA","year":"2014"},{"key":"p_28","volume-title":"Enamel pitting in childhood tuberous sclerosis. J Formos Med Assoc ;94(7):414-417","author":"Ho CS","year":"1995"},{"key":"p_29","volume-title":"Oral and neurocutaneous phenotypes of familial tuberous sclerosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod;111(1):87-94","author":"Araujo Lde J","year":"2011"},{"key":"p_30","volume-title":"Vigabatrin in Pediatric Epilepsy-An Open Study. J Child Neurol,;6(2):38-44","author":"Uldall P","year":"1991"}],"container-title":["Journal of Clinical Pediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/jcpd\/article-pdf\/44\/3\/190\/2561256\/1053-4625-44_3_10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/jcpd\/article-pdf\/44\/3\/190\/2561256\/1053-4625-44_3_10.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T11:46:20Z","timestamp":1658490380000},"score":1,"resource":{"primary":{"URL":"https:\/\/meridian.allenpress.com\/jcpd\/article\/44\/3\/190\/441772\/Oral-Findings-in-Children-Adolescents-and-Adults"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.17796\/1053-4625-44.3.10","relation":{},"ISSN":["1053-4628","1557-5268"],"issn-type":[{"value":"1053-4628","type":"print"},{"value":"1557-5268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]}}}