{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T09:04:14Z","timestamp":1713344654428},"reference-count":0,"publisher":"MRE Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>Objective: YKL-40, a new biomarker of localized inflammation, is secreted by macrophages and regulates inflammation and immune responses. The aim of this study was to investigate YKL-40 levels in saliva and compare the level of this mediator in healthy and unhealthy oral cavity. Study design: 80 children (42-girl, 38-boy), aged 6\u201315 (mean\u00b1SD: 9.35\u00b12.08) were included in this cross-sectional study. The children were divided into four groups: Group-I (control, n=20, dmft\/DMFT=0), Group-II (n=20, exist of dental caries), Group-III (n=20, exist of advanced dental caries without pulp exposure), and Group-IV (n=20, exist of advanced dental caries with pulp exposure). The dmft\/DMFT, dmfs\/DMFS, and the number of advanced dental caries according to the ICDAS and pufa\/PUFA index were recorded. Saliva was collected and YKL-40 concentrations were measured. Results: The highest level of YKL-40 was obtained in Group IV, followed by Groups III, II, and I, respectively (p&amp;lt;0.01). There was a positive correlation between YKL-40 and the number of caries There were no statistically significant difference in YKL-40 levels in terms of age and gender (p&amp;gt;0.05). Conclusions: The advanced dental caries with pulp exposure may play an important role in the increasing levels of YKL-40 in saliva.<\/jats:p>","DOI":"10.17796\/1053-4625-46.2.8","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T16:57:06Z","timestamp":1652115426000},"page":"137-142","source":"Crossref","is-referenced-by-count":2,"title":["Relationship Between Dental Caries and YKL-40 Levels in Saliva"],"prefix":"10.22514","volume":"46","author":[{"given":"Gulsum","family":"Duruk","sequence":"first","affiliation":[{"name":"*Gulsum Duruk, DDS, PhD, Department of Pediatric Dentistry, Faculty of Dentistry, Inonu University, Malatya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Laloglu","sequence":"additional","affiliation":[{"name":"**Esra Laloglu, MD, Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26027","published-online":{"date-parts":[[2022,5,9]]},"container-title":["Journal of Clinical Pediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/meridian.allenpress.com\/jcpd\/article-pdf\/46\/2\/137\/3056403\/i1557-5268-46-2-137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/jcpd\/article-pdf\/46\/2\/137\/3056403\/i1557-5268-46-2-137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T11:48:12Z","timestamp":1658490492000},"score":1,"resource":{"primary":{"URL":"https:\/\/meridian.allenpress.com\/jcpd\/article\/46\/2\/137\/481722\/Relationship-Between-Dental-Caries-and-YKL-40"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,5,9]]},"published-print":{"date-parts":[[2022,3,1]]}},"URL":"https:\/\/doi.org\/10.17796\/1053-4625-46.2.8","relation":{},"ISSN":["1557-5268","1053-4628"],"issn-type":[{"value":"1557-5268","type":"electronic"},{"value":"1053-4628","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}