{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:23:27Z","timestamp":1788564207959,"version":"build-2803163510"},"reference-count":0,"publisher":"MRE Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:p>Genetic polymorphisms could explain the inter-individual differences in the oral health-related quality of life (OHRQoL) of children with anterior open bite (AOB). Objective: To assess the impact of AOB on OHRQoL in children and to evaluate whether MTR (rs1805087), MTRR (rs1801394), TGF\u03b21 (rs1800469) and TNF-\u03b1 (rs1799964, rs1799724 and rs1800629) genes are potential biomarkers for OHRQoL in children with AOB. Study design: A cross-sectional study was performed with 173 children aged between 2\u20136 years. The Brazilian version of Early Childhood Oral Health Impact Scale (ECOHIS) was applied. Genetic polymorphisms were analyzed using real-time PCR. Mann-Whitney U-test and Chi-square were used. Results: The overall mean ECOHIS scores were 5.49 (SD= 5.72) and 3.45 (SD = 4.49) (p &amp;lt; 0.01) in the AOB and control groups, respectively. Children with the CC genotype of TNF-\u03b1 (rs1799724) had a significantly higher psychological QoL level. The MTRR AA genotype group showed a lower QoL level in the child subscale (p = 0.006), function (p = 0.017), and psychological (p = 0.006) domains. There was no significant difference between OHRQoL and the genetic polymorphisms in MTR and TGF\u03b21. Conclusions: Genetic polymorphisms in TNF-\u03b1 and MTRR are associated with the impact on the OHRQoL in children with AOB.<\/jats:p>","DOI":"10.17796\/1053-4625-46.3.12","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T14:54:39Z","timestamp":1657724079000},"page":"249-258","source":"Crossref","is-referenced-by-count":13,"title":["Evidence of Association between\n                    <i>MTRR<\/i>\n                    and\n                    <i>TNF-\u03b1<\/i>\n                    Gene Polymorphisms and Oral Health-Related Quality of Life in Children with Anterior Open Bite"],"prefix":"10.22514","volume":"46","author":[{"given":"Ellen Cardoso","family":"Teixeira","sequence":"first","affiliation":[{"name":"* Ellen Cardoso Teixeira, DDS, MSc, Postgraduate Program in Dentistry of Niter\u00f3i, School of Dentistry, Fluminense Federal University, Niter\u00f3i, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Moreira","family":"das Neves","sequence":"additional","affiliation":[{"name":"** Bruno Moreira das Neves, DDS, MSc, Postgraduate Program in Dentistry of Nova Friburgo, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuanny","family":"Castilho","sequence":"additional","affiliation":[{"name":"*** Thuanny Castilho, DDS, MSc, Postgraduate Program in Dentistry of Niter\u00f3i, School of Dentistry, Fluminense Federal University, Niter\u00f3i, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thayane","family":"Silva Ramos","sequence":"additional","affiliation":[{"name":"**** Thayane Silva Ramos, DDS, Clinical Research Unit, Fluminense Federal University, Niter\u00f3i, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriele","family":"Flaviana","sequence":"additional","affiliation":[{"name":"***** Adriele Flaviana, DDS, Clinical Research Unit, Fluminense Federal University, Niter\u00f3i, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Carelli","sequence":"additional","affiliation":[{"name":"****** Julia Carelli, DDS, MSc, School of Health Science, Positivo University,; School of Health Science, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Calvano","family":"Kuchler","sequence":"additional","affiliation":[{"name":"******* Erika Calvano Kuchler, DDS, MSc, PhD, School of Health Science, Positivo University, Curitiba, Paran\u00e1, Brazil; School of Health Science, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Nunes","family":"Germano","sequence":"additional","affiliation":[{"name":"******** Fabiana Nunes Germano, DDS, MSc, PhD, Postgraduate Program in Dentistry of Nova Friburgo, School of Dentistry, Fluminense Federal University. Department of Basic Science, Fluminense Federal University, Nova Friburgo, RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia Azeredo","family":"Alves Antunes","sequence":"additional","affiliation":[{"name":"********* L\u00edvia Azeredo Alves Antunes, DDS, MSc, PhD, Postgraduate Program in Dentistry of Niter\u00f3i, School of Dentistry, Fluminense Federal University, Niter\u00f3i, Rio de Janeiro. Postgraduate Program in Dentistry of Nova Friburgo, School of Dentistry, Fluminense Federal University. Department of Specific Formation of the Health Institute of Nova Friburgo (FFE-ISNF) Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Santos","family":"Antunes","sequence":"additional","affiliation":[{"name":"********** Leonardo Santos Antunes, DDS, MSc, PhD , Postgraduate Program in Dentistry of Niter\u00f3i, School of Dentistry, Fluminense Federal University, Niter\u00f3i, Rio de Janeiro. Postgraduate Program in Dentistry of Nova Friburgo, School of Dentistry, Fluminense Federal University. Department of Specific Formation of the Health Institute of Nova Friburgo (FFE-ISNF) Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26027","published-online":{"date-parts":[[2022,7,13]]},"container-title":["Journal of Clinical Pediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/meridian.allenpress.com\/jcpd\/article-pdf\/46\/3\/249\/3087062\/i1557-5268-46-3-249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/jcpd\/article-pdf\/46\/3\/249\/3087062\/i1557-5268-46-3-249.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T07:46:48Z","timestamp":1658476008000},"score":1,"resource":{"primary":{"URL":"https:\/\/meridian.allenpress.com\/jcpd\/article\/46\/3\/249\/483835\/Evidence-of-Association-between-MTRR-and-TNF-Gene"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,7,13]]},"published-print":{"date-parts":[[2022,5,1]]}},"URL":"https:\/\/doi.org\/10.17796\/1053-4625-46.3.12","relation":{},"ISSN":["1557-5268","1053-4628"],"issn-type":[{"value":"1557-5268","type":"electronic"},{"value":"1053-4628","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,1]]}}}