{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T19:07:53Z","timestamp":1788030473901,"version":"build-2784847793"},"reference-count":35,"publisher":"MRE Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:p>Objective: Beta Thalassemia (\u03b2T) patients present a unique facial appearance and specific craniofacial, jaw and dental patterns. Although this anomaly often requires orthodontic management, \u03b2T patients have received scant attention in the orthodontic and dental literature over the past 50 years. The aim of this article is to review the characteristic craniofacial and dental manifestation pattern of \u03b2T patients and to emphasize their preferred orthodontic management protocol by presenting a \u03b2T orthodontic treated patient. Case report: A 10 year old patient presented with a complaint of severe esthetic and functional disorders due to her diagnosis of \u03b2T. We initiated orthodontic treatment including a combined orthopedic and functional treatment modality to improve facial appearance. Results: Maxillary restraint and increased mandibular size during treatment along with an increase in the vertical dimension were achieved. The patient presented with Angle class I molar relationship, with reduction of the excessive overjet and deep overbite. Conclusion: Orthodontic treatment comprised of maxillary orthopedic treatment directed especially toward premaxilla with light forces, and mandibular modification by functional appliance along with fixed orthodontic treatment is recommended in \u03b2T patients.<\/jats:p>","DOI":"10.17796\/1053-4628-40.3.241","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T18:55:56Z","timestamp":1469818556000},"page":"241-246","source":"Crossref","is-referenced-by-count":20,"title":["Orthodontic Consideration in Patients with Beta-Thalassemia Major: Case Report and Literature Review"],"prefix":"10.22514","volume":"40","author":[{"given":"Shmuel","family":"Einy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagai","family":"Hazan-Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Ben-Barak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Aizenbud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26027","reference":[{"key":"p_1","volume-title":"Nathan and Oski's Hematology of Infancy and Childhood","author":"Nathan D","year":"2009"},{"key":"p_2","volume-title":"Clinical hematology","author":"Wintrobe M. M.","year":"1981"},{"key":"p_3","volume-title":"Hematology Basic Principles and Practice.","author":"Schwartz E","year":"1995"},{"key":"p_4","volume-title":"Roentgen Manifestations Cooley's Anemia. Ann N Y Acad Sci;119:641-661","author":"Baker DH.","year":"1964"},{"key":"p_5","volume-title":"Orthodontic Aspects of Cooley's Anemia. Ann N Y Acad Sci;119:662-663","author":"Asbell MB.","year":"1964"},{"key":"p_6","volume-title":"Dental and Oral Findings in Cooley's Anemia: A Study of Fifty Cases. Ann N Y Acad Sci;119:664-666","author":"Kaplan RI","year":"1964"},{"key":"p_7","volume-title":"P: H. Occlusion of the teeth in thalassemic patients. Birth Defects","author":"Pusaksrikit S","year":"1988"},{"key":"p_8","volume-title":"Periodontal condition and orofacial changes in patients with thalassemia major: a clinical and radiographic overview. J Clin Pediatr Dent;36:301-307","author":"Hattab FN.","year":"2012"},{"key":"p_9","volume-title":"dentoalveolar, and soft tissue cephalometric measurements of Malay transfusion-dependent thalassaemia patients. Eur J Orthod","author":"Toman HA","year":"2011"},{"key":"p_11","volume-title":"al-Omari MA. Cephalometric measurements and facial deformities in subjects with beta-thalassaemia major. Eur J Orthod;24:9-19","author":"Abu Alhaija ES","year":"2002"},{"key":"p_12","volume-title":"Effects of thalassaemia major on components of the craniofacial complex. Br J Orthod ;23:157-162","author":"Bassimitci S","year":"1996"},{"key":"p_13","volume-title":"Management of the thalassemia-induced skeletal facial deformity: case reports and review of the literature. J Oral Maxillofac Surg;55:1331-1339","author":"Drew SJ","year":"1997"},{"key":"p_14","volume-title":"Cooley's anemia--orthodontic and surgical treatment. Am J Orthod;74:444-449","author":"Silling G","year":"1978"},{"key":"p_15","volume-title":"Associated orthodontic, surgical and hematological management of Cooley s anemia. Report of a case. Minerva Stomatol;50:47-54","author":"Gotte P","year":"2001"},{"key":"p_16","volume-title":"The face in profile: An anthropological X ray investigation on Swedish children and conscripts Berlingska Boktryckeriet. Lund","author":"Bjork A.","year":"1949"},{"key":"p_17","volume-title":"Reconstruction of the maxilla in thalassemia. Ann N Y Acad Sci;165:437-442","author":"Jurkiewicz MJ","year":"1969"},{"key":"p_18","volume-title":"The control of vertical overbite in clinical orthodontics. Angle Orthod;38:19-39","author":"Schudy FF.","year":"1968"},{"key":"p_19","volume-title":"Handbook of orthodontics for students and general practitioner","author":"Moyers R.","year":"1973"},{"key":"p_20","volume-title":"Cephalofacial deformities in thalassemia major (Cooley's anemia). A correlative study among 138 cases. Am J Dis Child;121:300-306","author":"Logothetis J","year":"1971"},{"key":"p_21","volume-title":"Surgical reconstruction of the maxilla in severe thalassemia. Plast Reconstr Surg;39:459-464","author":"Jurkiewicz MJ","year":"1967"},{"key":"p_22","volume-title":"The dentoalveolar compensatory mechanism: background and clinical implications. Br J Orthod;7:145-161","author":"Solow B.","year":"1980"},{"key":"p_23","volume-title":"Cooley's anemia from an orthodontic viewpoint. N Y State Dent J;31:405-408","author":"Adelman AB.","year":"1965"},{"key":"p_24","volume-title":"Soft-tissue profile characteristics in children with beta thalassaemia major. Acta Odontol Scand;71:1071-1076","author":"Amini F","year":"2013"},{"key":"p_25","volume-title":"A 5-year follow-up of 66 patients]. Presse Med;18:1010-1013","author":"Adjrad L","year":"1989"},{"key":"p_26","first-page":"41","volume-title":"Lopez-Gonzalez Garrido Jde D. Thalassemias and their dental implications. Med Oral;7:36-40","author":"Cutando Soriano A","year":"2002"},{"key":"p_27","volume-title":"Craniofacial deformities in transfusion-dependent thalassemia patients in Malaysia: prevalence and effect of treatment. Southeast Asian J Trop Med Public Health;42:1233-1240","author":"Toman HA","year":"2011"},{"key":"p_28","volume-title":"Patterns of Growth in Children with Thalassemia Major. Ann N Y Acad Sci;119:667-679","author":"Johnston FE","year":"1964"},{"key":"p_29","volume-title":"Cooley's anemia: a review of the roentgenographic findings in the skeleton: Hickey lecture","author":"Caffey J.","year":"1957"},{"key":"p_30","volume-title":"Skeletal and dental retardation in beta-thalassemia major. Hum Biol;54:85-92","author":"Laor E","year":"1982"},{"key":"p_31","volume-title":"Physical growth parameters in thalassemic children. Indian J Pediatr;64:861-871","author":"George A","year":"1997"},{"key":"p_32","volume-title":"Body growth in Cooley's anemia (homozygous beta-thalassemia) with a correlative study as to other aspects of the illness in 138 cases. Pediatrics;50:92-99","author":"Logothetis J","year":"1972"},{"key":"p_33","volume-title":"Patterns of physical growth and dental development in Jordanian children and adolescents with thalassemia major. J Oral Sci;55:71-77","author":"Hattab FN.","year":"2013"},{"key":"p_34","volume-title":"Changes visible in radiographs used in dentistry. Oral Surg Oral Med Oral Pathol;25:564-576","author":"Poyton HG","year":"1968"},{"key":"p_35","volume-title":"Current Principles and Techniques The Mosby Co","author":"Graber T","year":"2005"},{"key":"p_36","volume-title":"Lefort 1 osteotomy in a beta-thalassemia major patient--a case report. 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