{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:10:44Z","timestamp":1790356244934,"version":"4.1.0"},"reference-count":26,"publisher":"MRE Press","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:p>Silver-Russell syndrome (SRS) is a very rare genetic disorder characterized by intrauterine growth retardation, short stature, and typical craniofacial abnormalities including micrognathia. While growth hormone (GH) therapy in children with SRS significantly improves somatic growth, functional orthopedic treatment can also be effective in adolescents with mandibular deficiency. We report the effects of Phase 1 functional orthopedic treatment of a twin-block appliance in conjunction with GH administration in a 9-year-old boy with GH deficiency and SRS, and the result of the subsequent Phase 2 orthodontic treatment.<\/jats:p>","DOI":"10.17796\/1053-4628-41.5.392","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T19:08:17Z","timestamp":1504638497000},"page":"392-397","source":"Crossref","is-referenced-by-count":4,"title":["Orthodontic Treatment in Conjunction with Twin-bock Treatment and Growth Hormone Therapy in Silver Russell Syndrome"],"prefix":"10.22514","volume":"41","author":[{"given":"Su-Jin","family":"Ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Dae","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyounga","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26027","reference":[{"key":"p_1","first-page":"205","volume":"9","author":"Eggermann T","journal-title":"Diagnostic proceeding in Silver-Russell syndrome. Mol Diagn;"},{"key":"p_2","volume-title":"Syndrome of congenital hemihypertrophy, shortness of stature, and elevated urinary gonadotropins. Pediatrics;12:368-76","author":"Silver HK","year":"1953"},{"key":"p_3","volume-title":"Proc R Soc Med;47:1040-4.","author":"Russell A.","year":"1954"},{"key":"p_4","volume-title":"Reevaluation of Russell-Silver syndrome. J Pediatr;107:733-7","author":"Saal HM","year":"1985"},{"key":"p_6","volume-title":"Silver-Russell syndrome with unusual findings. Pediatrics;79:125-8","author":"Hansen KK","year":"1987"},{"key":"p_7","volume-title":"Growth and symptoms in Silver-Russell syndrome: review on the basis of 386 patients. Eur J Pediatr;154:958-68","author":"Wollmann HA","year":"1995"},{"key":"p_8","volume-title":"Craniofacial and dental characteristics of Silver-Russell syndrome. Am J Med Genet;56:229-36","author":"Kotilainen J","year":"1995"},{"key":"p_9","volume-title":"Growth hormone therapy in Silver Russell syndrome: 5 years experience of the Australian and New Zealand Growth database (OZGROW). Eur J Pediatr;155:851-7","author":"Rakover Y","year":"1996"},{"key":"p_10","doi-asserted-by":"crossref","DOI":"10.1034\/j.1600-0722.2000.108005359.x","volume-title":"Craniofacial morphology, dental occlusion, tooth eruption, and dental maturity in boys of short stature with or without growth hormone deficiency. Eur J Oral Sci ;108:359-67","author":"Kjellberg H","year":"2000"},{"key":"p_11","volume-title":"Craniofacial morphology and dental age in children with Silver-Russell syndrome. Orthod Craniofac Res;6:54-62","author":"Bergman A","year":"2003"},{"key":"p_14","volume-title":"Distraction osteogenesis in Silver Russell syndrome to expand the mandible. Am J Orthod Dentofacial Orthop;116:25-30","author":"Kisnisci RS","year":"1999"},{"key":"p_15","volume-title":"Functional appliance therapy in conjunction with growth hormone treatment. A case report. Br J Orthod;22:361-5","author":"Davies TI","year":"1995"},{"key":"p_16","volume-title":"Orthodontic treatment with growth hormone therapy in a girl of short stature. Am J Orthod Dentofacial Orthop;126:118-26","author":"Hwang CJ","year":"2004"},{"key":"p_17","volume-title":"Differential growth and maturation in idiopathic growth-hormone-deficient children. Eur J Orthod;19:131-9","author":"Cantu G","year":"1997"},{"key":"p_18","volume-title":"Growth hormone and craniofacial changes: preliminary data from studies in Turner's syndrome. Pediatrics;104:1021-4","author":"Simmons KE.","year":"1999"},{"key":"p_19","volume-title":"Endocrine regulation of craniofacial growth. 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