{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T13:36:17Z","timestamp":1785591377103,"version":"3.56.0"},"reference-count":19,"publisher":"ECO-Vector LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["consortium-psy.com"],"crossmark-restriction":false},"short-container-title":["Consortium PSYCHIATRICUM"],"abstract":"<jats:p>BACKGROUND: Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involvement of a significant portion of the body surface area. To date, no association between GBFDE and chlordiazepoxide has been reported in the literature.\r\nCASE REPORT: The authors present the case of a 40-year-old male inpatient in the psychiatry department of a tertiary care hospital in Assam, India. The patient was admitted in an alcohol withdrawal state and was initially prescribed chlordiazepoxide at a dose of 60 mg\/day. He developed GBFDE within a day of chlordiazepoxide administration. The drug was discontinued, and he was treated with oral and topical corticosteroids instead, resulting in a significant improvement.\r\nCONCLUSION: \u0421hlordiazepoxide is a rare but potential trigger of GBFDE. Clinicians should closely monitor patients on chlordiazepoxide for possible signs of GBFDE.<\/jats:p>","DOI":"10.17816\/cp15563","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T04:42:27Z","timestamp":1741668147000},"page":"30-36","update-policy":"https:\/\/doi.org\/10.17816\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":2,"title":["Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effect"],"prefix":"10.17816","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-6457","authenticated-orcid":false,"given":"Rishabh","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav Kumar","family":"Sudhanshu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Shafiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-5091","authenticated-orcid":false,"given":"Markanday","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7284","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02853.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57090925"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1125754"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12133"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.015"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1993.tb02093.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1983.tb05502.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1989.tb00737.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5070\/D3237035734"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0225"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Pretzlaff KM, Pandya AG, Dominguez AR. Fixed drug eruptions. In: Hall JC, Hall BH, editors. Cutaneous Drug Eruptions: Diagnosis, Histopathology and Therapy. London: Springer; 2015. p. 181\u2013192.","DOI":"10.1007\/978-1-4471-6729-7_17"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/jdds.jdds_35_20"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/8755122517753595"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Blair HM. Letter: Fixed drug eruption from chlordiazepoxide. Arch Dermatol. 1974;109(6):914. PMID: 4275331","DOI":"10.1001\/archderm.1974.01630060082035"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2019.01.009"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5530\/jyp.2016.2.22"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Chang AY. Fixed Drug Eruption. In: Rosenbach M, Wanat KA, Micheletti RG, et al., editors. Inpatient Dermatology. London: Springer; 2018. p. 41\u201343.","DOI":"10.1007\/978-3-319-18449-4_8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00505-3"}],"container-title":["Consortium PSYCHIATRICUM"],"original-title":[],"link":[{"URL":"https:\/\/consortium-psy.com\/jour\/article\/viewFile\/15563\/pdf_2","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/consortium-psy.com\/jour\/article\/viewFile\/15563\/pdf_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T07:46:32Z","timestamp":1754898392000},"score":1,"resource":{"primary":{"URL":"https:\/\/consortium-psy.com\/jour\/article\/view\/15563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.17816\/cp15563","relation":{},"ISSN":["2713-2919","2712-7672"],"issn-type":[{"value":"2713-2919","type":"electronic"},{"value":"2712-7672","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,1]]}}}