{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:57:37Z","timestamp":1774979857677,"version":"3.50.1"},"reference-count":60,"publisher":"ECO-Vector LLC (Publications)","issue":"1","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["consortium-psy.com"],"crossmark-restriction":false},"short-container-title":["Consortium PSYCHIATRICUM"],"abstract":"<jats:p>BACKGROUND: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with a globally increasing prevalence. Early detection is crucial for effective intervention, yet current diagnostic methods often result in delays. Emerging research suggests that prenatal biomarkers, including structural anomalies detectable via ultrasound, may offer opportunities for earlier identification.\r\nAIM: To synthesize current evidence on prenatal ultrasound-detectable anomalies associated with ASD and assess their potential as early predictors.\r\nMETHODS: A comprehensive literature search was conducted across PubMed, Scopus, and Google Scholar for studies published between 2007 and 2025. Keywords included \u201cautism spectrum disorder\u201d, \u201cprenatal ultrasound\u201d, \u201cfetal anomalies\u201d, \u201cpreeclampsia\u201d, \u201cneurodevelopment\u201d and \u201cbiomarkers\u201d. Priority was given to recent and high-quality studies, including systematic reviews and large cohort analyses. The selected articles were read in full, and their key findings were summarized in a narrative form. The synthesis focused on describing the scope of the existing evidence, the prenatal ultrasound findings reported in relation to ASD, and on highlighting recurrent patterns or notable differences between studies.\r\nRESULTS: Several studies report associations between ASD and prenatal anomalies such as ventriculomegaly, increased biparietal diameter, hyperechogenic kidneys, and congenital heart defects. However, these findings are not specific to ASD and show inconsistent predictive performance. Sensitivity and specificity vary widely across studies, and ethical concerns about overdiagnosis and disparities in access to care persist.\r\nCONCLUSION: Prenatal ultrasound may contribute to early ASD risk identification but lacks the accuracy required for standalone diagnosis. Integrating ultrasound findings with genetic and postnatal data, along with standardized protocols and further research, is essential to improve its predictive value and clinical application.<\/jats:p>","DOI":"10.17816\/cp15700","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T09:41:05Z","timestamp":1772617265000},"page":"24-35","update-policy":"https:\/\/doi.org\/10.17816\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal ultrasound\u2013detected structural anomalies associated with autism spectrum disorder: a narrative review"],"prefix":"10.17816","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-5007","authenticated-orcid":false,"given":"Nazyar","family":"Khamenehei","sequence":"additional","affiliation":[{"name":"Ural Federal University named after the first President of Russia B.N. Yeltsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-9227","authenticated-orcid":false,"given":"Lyudmila V.","family":"Tokarskaya","sequence":"additional","affiliation":[{"name":"Ural Federal University named after the first President of Russia B.N. Yeltsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55386","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref1","unstructured":"Diagnostic and statistical manual of mental disorders. 5th ed. Washington: American Psychiatric Association Publishing; 2013."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.15585\/MMWR.SS7011A1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2696"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.24171\/j.phrp.2024.0286"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7402a1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2016.07.016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2014.03.007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.210"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1071181"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(24)00363-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716003457"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.43226"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/children11111311"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.11.53"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-007-0440-y"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.03.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/nature21369"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00407-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-007-0495-9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2017.08.008"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-022-00600-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.145"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01178-6"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1866-1955-5-28"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-022-00490-w"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1176\/APPI.AJP.21100992"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1514678"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/children11080957"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-024-00586-5"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.11.003"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.03.020"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-024-09573-6"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15060769"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.33590\/emj\/mkpn4473"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpsy.2021.10.001"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1101\/2024.07.30.602578"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxac100.008"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2018.1519693"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s10278-024-00987-1"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2017.27"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2022.05.133"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1177\/13623613221118430"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac008"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951123000598"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-023-09478-w"},{"key":"ref46","unstructured":"University of California. Study may show a way to predict whether children with a genetic disorder will develop autism or psychosis [Internet]. 2015 [cited 2025 Dec 12]. Available from: https:\/\/medicalxpress.com\/news\/2015-07-children-genetic-disorder-autism-psychosis.html"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579420000942"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26094"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1206042"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29186"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.05.016"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56090428"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.03.007"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.45719"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1307491"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-1084"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7307"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01050.x"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.794069"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abh1663"}],"container-title":["Consortium PSYCHIATRICUM"],"original-title":[],"link":[{"URL":"https:\/\/consortium-psy.com\/jour\/article\/viewFile\/15700\/482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/consortium-psy.com\/jour\/article\/viewFile\/15700\/482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:05:50Z","timestamp":1774976750000},"score":1,"resource":{"primary":{"URL":"https:\/\/consortium-psy.com\/jour\/article\/view\/15700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,31]]}},"URL":"https:\/\/doi.org\/10.17816\/cp15700","relation":{},"ISSN":["2713-2919","2712-7672"],"issn-type":[{"value":"2713-2919","type":"electronic"},{"value":"2712-7672","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}