{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:19:34Z","timestamp":1776100774179,"version":"3.50.1"},"reference-count":53,"publisher":"ECO-Vector LLC (Publications)","issue":"4","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["consortium-psy.com"],"crossmark-restriction":false},"short-container-title":["Consortium PSYCHIATRICUM"],"abstract":"<jats:p>BACKGROUND: Anorexia nervosa (AN) is characterized by heterogeneous clinical manifestations, which complicates diagnosis and treatment. It is important to define the clinical variants and therapeutic targets for AN.\r\nAIM: To identify empirical patient phenotypes within the AN diagnostic category using Latent Class Analysis (LCA) of clinically assessed psychopathological symptoms.\r\nMETHODS: Psychiatrists clinically assessed psychopathological symptoms of AN using an original checklist (57 symptoms in total) and the Mini-International Neuropsychiatric Interview (M.I.N.I.) was used to identify mental disorders. Patients completed the Symptom Check List-90-Revised questionnaire (SCL-90-R) to self-assess psychopathological symptoms and distress. Clinically homogeneous patient subgroups were identified using LCA.\r\nRESULTS: A total of 115 patients with AN were examined. Based on the LCA, four patient groups (C1\u2013C4) were identified, with high classification certainty (R\u00b2=0.908), model significance (p0.001), and clear separation of the latent groups (class separation index = 0.957). ED-related symptoms were key determinants of class formation only in 68 patients (59%) \u2014 those in C1 and C3. No statistically significant differences were found between classes on any SCL-90-R subscales or most M.I.N.I. diagnoses. In C1 (n=41), core ED symptoms dominated: dysmorphophobia, fears related to eating, weight gain, loss of control. In C2, low frequencies are observed for core ED symptoms; this group was characterized by a high incidence of sleep disturbances, anxiety, apathy, melancholy, and anhedonia. C3 represents a polymorphic clinical profile with a combination of core ED symptoms, affective symptoms, thought disorders, cognitive impairments, and sleep disturbances. C4 was defined by the presence of hypochondriacal concerns, somatoform autonomic symptoms, and apathy; none of the core ED symptoms were typical for C4.\r\nCONCLUSION: Four empirically derived clinical phenotypes of AN were identified, each characterized by a distinct symptomatic profile. Each phenotype was defined by specific combinations of core ED symptoms and general psychopathological manifestations.<\/jats:p>","DOI":"10.17816\/cp15730","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T17:41:24Z","timestamp":1766079684000},"page":"5-22","update-policy":"https:\/\/doi.org\/10.17816\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":0,"title":["Clinical phenotypes of anorexia nervosa: mathematical models based on latent class analysis of psychopathological symptoms"],"prefix":"10.17816","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0958-0596","authenticated-orcid":false,"given":"Olga A.","family":"Karpenko","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-1601","authenticated-orcid":false,"given":"Timur S.","family":"Syunyakov","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-4367","authenticated-orcid":false,"given":"Alexander B.","family":"Berdalin","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia V.","family":"Evlampieva","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0970-4932","authenticated-orcid":false,"given":"Olga V.","family":"Andrianova","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7785-4353","authenticated-orcid":false,"given":"Laura E.","family":"Gilmutdinova","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alla V.","family":"Novichkova","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0060-0374","authenticated-orcid":false,"given":"Andrey K.","family":"Aleksanian","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3001-1505","authenticated-orcid":false,"given":"Julia A.","family":"Nikolkina","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7158-9041","authenticated-orcid":false,"given":"Evgeniya V.","family":"Mazurova","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5911-9992","authenticated-orcid":false,"given":"Aleksey A.","family":"Shafarenko","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2510-3128","authenticated-orcid":false,"given":"Lyudmila S.","family":"Satyanova","sequence":"additional","affiliation":[{"name":"Mental-health clinic No. 1 named after N.A. Alexeev"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55386","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"ref1","unstructured":"B80 Anorexia Nervosa [Internet]. In: ICD-11 for Mortality and Morbidity Statistics. Geneva: World Health Organization; \u04412025 [cited 2025 September 2]. 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