{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:45:54Z","timestamp":1774939554036,"version":"3.50.1"},"reference-count":22,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Fam Plann Reprod Health Care"],"accepted":{"date-parts":[[2004,3,3]]},"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Polycystic ovary syndrome (PCOS) is the commonest endocrine disturbance affecting women in the reproductive age group and encompasses signs of hyperandrogenism, menstrual cycle disturbances and obesity. Some of the symptoms of PCOS may be ameliorated by the combined oral contraceptive pill (COCP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A pilot observational study was carried out in a university teaching hospital setting to determine whether the clinical and biochemical features of PCOS are ameliorated by a new COCP, Yasmin\u00ae, which contains a new progestogen, drosperinone. Treatment with Yasmin was given for 6 months to 17 patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirteen patients (76%) completed 6 months of therapy. Good cycle control was achieved in all patients. Percentage body fat increased, with no overall change in body mass index. Fasting insulin and triglyceride concentrations rose significantly. Serum total testosterone concentrations fell with a concomitant rise in sex hormone binding globulin levels. Hirsutism scores did not change significantly in the 12 women who were clinically hirsute. There was, however, a significant improvement in the acne scores. Four of the 17 patients dropped out of the trial between Cycles 3 and 5 due to side effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Yasmin provides good cycle control for women with PCOS, with an improvement in acne over 6 months but not in other symptoms of the syndrome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1783\/1471189041261636","type":"journal-article","created":{"date-parts":[[2005,3,5]],"date-time":"2005-03-05T01:30:57Z","timestamp":1109986257000},"page":"163-165","source":"Crossref","is-referenced-by-count":43,"title":["An observational study of Yasmin\u00ae in the management of women with polycystic ovary syndrome"],"prefix":"10.1136","volume":"30","author":[{"given":"Manisha","family":"Palep-Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Mook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Barth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Balen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S0140-6736(99)00218-4","article-title":"The pathogenesis of polycystic ovary syndrome: the enigma unravels","volume":"354","author":"Balen, A.H.","year":"1999","unstructured":"Balen AH. The pathogenesis of polycystic ovary syndrome: the enigma unravels. Lancet 1999; 354: 966\u2013967.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0140-6736(88)91612-1","article-title":"Polycystic ovaries \u2013 a common finding in normal women","volume":"1","author":"Polson, D.W.; Wadsworth, J.; Adams, J.","year":"1988","unstructured":"Polson DW, Wadsworth J, Adams J, et al. Polycystic ovaries \u2013 a common finding in normal women. Lancet 1988; 1: 870\u2013872.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1365-2265.1999.00886.x","article-title":"Polycystic ovaries and associated clinical and biochemical features in young women","volume":"51","author":"Michelmore, K.F.; Balen, A.H.; Dunger, D.B.","year":"1999","unstructured":"Michelmore KF, Balen AH, Dunger DB et al. Polycystic ovaries and associated clinical and biochemical features in young women. 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Carbohydrate metabolism during treatment with estrogen, progesterone low dose contraceptives. Am J Obstet Gynecol 1982; 142(6 Pt 2): 732\u2013734.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_18","first-page":"1","article-title":"Clinical relevance of plasma lipid changes during the use of new low dose oral contraceptives","volume":"7","author":"Gaspard, U.J.","year":"1991","unstructured":"Gaspard UJ. Clinical relevance of plasma lipid changes during the use of new low dose oral contraceptives. 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Hum Reprod 1998; 13: 2706\u20132711.","journal-title":"Hum Reprod"},{"issue":"678 511","key":"ref_21","article-title":"Correspondence: Mrs June Keeling, Practice Development Research Unit, Duchess of Westminster","volume":"0","author":"Wing, Arrowe Park Hospital; Road, Arrowe Park; Upton, Wirral","year":"2004","unstructured":"Correspondence: Mrs June Keeling, Practice Development Research Unit, Duchess of Westminster Wing, Arrowe Park Hospital, Arrowe Park Road, Upton, Wirral, Merseyside CH49 5PE, UK. Tel: +44 (0) 678 511 ext 2409. E-mail:j.keeling@chester.ac.uk (Accepted 25 April 2004)","journal-title":"Tel; Merseyside CH49 5PE, UK"},{"issue":"3","key":"ref_22","first-page":"165","article-title":"Family Planning and","volume":"30","author":"of, Journal","year":"2004","unstructured":"Journal of Family Planning and Reproductive Health Care 2004; 30(3): 165\u2013168","journal-title":"Reproductive Health Care"}],"container-title":["Journal of Family Planning and Reproductive Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1783\/1471189041261636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T17:37:59Z","timestamp":1757093879000},"score":1,"resource":{"primary":{"URL":"https:\/\/jfprhc.bmj.com\/lookup\/doi\/10.1783\/1471189041261636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,7,1]]},"published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1783\/1471189041261636"],"URL":"https:\/\/doi.org\/10.1783\/1471189041261636","relation":{},"ISSN":["1471-1893","2045-2098"],"issn-type":[{"value":"1471-1893","type":"print"},{"value":"2045-2098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}