{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:50:19Z","timestamp":1757616619728,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Fam Plann Reprod Health Care"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1783\/147118910791069394","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T19:26:02Z","timestamp":1270754762000},"page":"105-106","source":"Crossref","is-referenced-by-count":5,"title":["LNG may still be the best oral EC option"],"prefix":"10.1136","volume":"36","author":[{"given":"Rudiger","family":"Pittrof","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Punam","family":"Rubenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1783\/147118910790290911","article-title":"The need to take a \u2018new look\u2019 at emergency contraception","volume":"36","author":"Cameron, S.; Glasier, A.","year":"2010","unstructured":"Cameron S, Glasier A. The need to take a \u2018new look\u2019 at emergency contraception. J Fam Plann Reprod Health Care 2010; 36: 3\u20134.","journal-title":"J Fam Plann Reprod Health Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1783\/147118909789587141","article-title":"EllaOne\u00ae: a second-generation emergency contraceptive?","volume":"35","author":"Mansour, D.","year":"2009","unstructured":"Mansour D. EllaOne\u00ae: a second-generation emergency contraceptive? J Fam Plann Reprod Health Care 2009; 35: 217\u2013218.","journal-title":"J Fam Plann Reprod Health Care"},{"issue":"2","key":"ref_3","article-title":"Fam Plann Reprod","volume":"36","author":"FSRH, J.","year":"2010","unstructured":"\u00a9FSRH J Fam Plann Reprod Health Care 2010: 36(2)","journal-title":"Health Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0140-6736(10)60101-8","article-title":"levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis","volume":"375","year":"2010","unstructured":"levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis. Lancet 2010; 375: 555\u2013562.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1097\/01.AOG.0000239440.02284.45","article-title":"Progesterone receptor modulator for emergency contraception: a randomized controlled trial","volume":"108","author":"Creinin, M.D.; Schlaff, W.; Archer, D.F.; Wan, L.; Frezieres, R.; Thomas, M.","year":"2006","unstructured":"Creinin MD, Schlaff W, Archer DF, Wan L, Frezieres R, Thomas M, et al. Progesterone receptor modulator for emergency contraception: a randomized controlled trial. Obstet Gynecol 2006; 108: 1089\u20131097.","journal-title":"Obstet Gynecol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/S0140-6736(02)11767-3","article-title":"et al; WHO Research Group on Postovulatory Methods of Fertility Regulation. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial","volume":"360","author":"von Hertzen H; G, Piaggio; J, Ding; J, Chen; S, Song; G, B\u00e1rtfai","year":"2002","unstructured":"von Hertzen H, Piaggio G, Ding J, Chen J, Song S, B\u00e1rtfai G, et al; WHO Research Group on Postovulatory Methods of Fertility Regulation. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. Lancet 2002; 360: 1803\u20131810.","journal-title":"Lancet"},{"key":"ref_7","article-title":"Ulipristal acetate compared to levonorgestrel for emergency contraception within five days of unprotected intercourse: a randomized controlled trial. Abstract presented at the 8th Congress of the European Society of Gynecology","author":"Cameron, S.; Glasier, A.; Fine, P.; Math\u00e9, H.; Gainer, E.","year":"2009","unstructured":"Cameron S, Glasier A, Fine P, Math\u00e9 H, Gainer E. Ulipristal acetate compared to levonorgestrel for emergency contraception within five days of unprotected intercourse: a randomized controlled trial. Abstract presented at the 8th Congress of the European Society of Gynecology, Rome, Italy, 10\u201313 September 2009."},{"key":"ref_8","first-page":"001324","article-title":"Interventions for emergency contraception","volume":"2","author":"Cheng, L.; G\u00fclmezoglu, A.M.; Piaggio, G.; Ezcurra, E.; Van Look, P.F.","year":"2008","unstructured":"Cheng L, G\u00fclmezoglu AM, Piaggio G, Ezcurra E, Van Look PF. Interventions for emergency contraception. Cochrane Database Syst Rev 2008; 2: CD001324.","journal-title":"Cochrane Database Syst Rev"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1783\/147118910790290911","article-title":"The need to take a \u2018new look\u2019 at emergency contraception","volume":"36","author":"Cameron, S.; Glasier, A.","year":"2010","unstructured":"Cameron S, Glasier A. The need to take a \u2018new look\u2019 at emergency contraception. J Fam Plann Reprod Health Care 2010; 36: 3\u20134.","journal-title":"J Fam Plann Reprod Health Care"},{"key":"ref_10","article-title":"ellaOne 30 mg: Summary of Product Characteristics","author":"Ltd, H.R.A.Pharma U.K.","year":"2009","unstructured":"HRA Pharma UK Ltd. ellaOne 30 mg: Summary of Product Characteristics. 2009. http:\/\/emc.medicines.org.uk\/medicine\/22280\/SPC\/ellaOne+30+mg\/[Accessed 4 February 2010]."},{"key":"ref_11","article-title":"The effects of immediate pre-ovulatory administration of 30 mg ulipristal acetate on follicular rupture. Abstract presented at the 8th Congress of the European Society of Gynecology","author":"Croxatto, H.B.; Brache, V.; Cochon, L.; Jesam, C.; Salvatierra, A.M.; Levy, D.","year":"2009","unstructured":"Croxatto HB, Brache V, Cochon L, Jesam C, Salvatierra AM, Levy D, et al. The effects of immediate pre-ovulatory administration of 30 mg ulipristal acetate on follicular rupture. Abstract presented at the 8th Congress of the European Society of Gynecology, Rome, Italy, 10\u201313 September 2009."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jadohealth.2006.10.018","article-title":"Depo now: preventing unintended pregnancies among adolescents and young adults","volume":"40","author":"Rickert, VI, Tiezzi; L, Lipshutz; J, Le\u00f3n; J, Vaughan; RD, Westhoff; C.","year":"2007","unstructured":"Rickert VI, Tiezzi L, Lipshutz J, Le\u00f3n J, Vaughan RD, Westhoff C. Depo now: preventing unintended pregnancies among adolescents and young adults. J Adolesc Health 2007; 40: 22\u201328.","journal-title":"J Adolesc Health"},{"key":"ref_13","article-title":"We discussed the possible interaction of a progesterone receptor modulator (PRM) with hormonal contraception in our commentary in this Journal8 and concluded that further research is required, because the requirement to abstain or use barrier methods for the remainder","volume-title":"evidence based","year":"of the month is not","unstructured":"We discussed the possible interaction of a progesterone receptor modulator (PRM) with hormonal contraception in our commentary in this Journal8 and concluded that further research is required, because the requirement to abstain or use barrier methods for the remainder of the month is not evidence based."},{"article-title":"Rubenstein and Sauer express concern that women who cannot access National Health Service abortion services may try to procure several doses of UPA from different clinics with the intention of trying to induce an abortion (unproven effect), or sell the product on the \u2018black market\u2019 at \u2018real\u2019 value. This course of action seems unlikely since a woman could more easily purchase an effective treatment (mifepristone and misoprostol) over the Internet, at an affordable price (www. womenonweb.org).9 As we discussed in our commentary8 in this Journal, UPA does by virtue of the fact that it is a PRM raise issues for service delivery and for \u2018bridging\u2019 contraception. However, in spite of these challenges, we believe that contraceptive service providers will judge the evidence for themselves, and welcome UPA as an advance in EC that is more likely to help women avoid an unintended pregnancy than LNG","author":"Pittrof, Drs","key":"ref_14","unstructured":"Drs Pittrof, Rubenstein and Sauer express concern that women who cannot access National Health Service abortion services may try to procure several doses of UPA from different clinics with the intention of trying to induce an abortion (unproven effect), or sell the product on the \u2018black market\u2019 at \u2018real\u2019 value. This course of action seems unlikely since a woman could more easily purchase an effective treatment (mifepristone and misoprostol) over the Internet, at an affordable price (www. womenonweb.org).9 As we discussed in our commentary8 in this Journal, UPA does by virtue of the fact that it is a PRM raise issues for service delivery and for \u2018bridging\u2019 contraception. However, in spite of these challenges, we believe that contraceptive service providers will judge the evidence for themselves, and welcome UPA as an advance in EC that is more likely to help women avoid an unintended pregnancy than LNG."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1783\/147118910791069394","article-title":"LNG may still be the best oral EC option","volume":"36","author":"Pittrof, R.; Rubenstein, P.; Sauer, U.","year":"2010","unstructured":"Pittrof R, Rubenstein P, Sauer U. LNG may still be the best oral EC option [Letter]. J Fam Plann Reprod Health Care 2010; 36: 105\u2013106.","journal-title":"J Fam Plann Reprod Health Care"},{"key":"ref_16","first-page":"442","article-title":"The effects of immediate pre-ovulatory administration of 30 mg ulipristal acetate on follicular rupture. Abstract presented at the 8th Congress of the European Society of Gynecology","volume":"3","author":"Croxatto, H.B.; Brache, V.; Cochon, L.","year":"2009","unstructured":"Croxatto HB, Brache V, Cochon L, et al. The effects of immediate pre-ovulatory administration of 30 mg ulipristal acetate on follicular rupture. Abstract presented at the 8th Congress of the European Society of Gynecology, Rome, Italy, 10\u201313 September 2009 3 Croxatto HB, Brache V, Pavez M, Cochon L, Forcelledo ML, Alvarez F, et al. Pituitary\u2013ovarian function following the standard levonorgestrel emergency contraceptive dose or a single 0.75-mg dose given on the days preceding ovulation. Contraception 2004; 70: 442\u2013450.","journal-title":"Contraception; Pituitary\u2013ovarian function following the standard levonorgestrel emergency contraceptive dose or a single 0.75-mg dose given on the days preceding ovulation"},{"key":"ref_17","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.057","article-title":"Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914","volume-title":"Fertil Steril 2009; published online","author":"Stratton, P.; Levens, E.D.; Hartog, B.; Piquion, J.; Wei, Q.; Merino, M.","year":"2009","unstructured":"Stratton P, Levens ED, Hartog B, Piquion J, Wei Q, Merino M, et al. Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914. Fertil Steril 2009; published online 5 February 2009. DOI:10.1016\/ j.fertnstert. 2008.12.057."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/humupd\/dmh027","article-title":"Mechanisms of action of mifepristone and levonorgestrel when used for emergency contraception","volume":"10","author":"Gemzell-Danielsson, K.; Marions, L.","year":"2004","unstructured":"Gemzell-Danielsson K, Marions L. Mechanisms of action of mifepristone and levonorgestrel when used for emergency contraception. Hum Reprod Update 2004; 10: 341\u2013348.","journal-title":"Hum Reprod Update"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0140-6736(10)60101-8","article-title":"Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis","volume":"375","author":"Glasier, A.F.; Cameron, S.T.; Fine, P.M.; Logan, S.J.; Casale, W.; Van Horn, J.","year":"2010","unstructured":"Glasier AF, Cameron ST, Fine PM, Logan SJ, Casale W, Van Horn J, et al. Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis. Lancet 2010; 375: 555\u2013562.","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1783\/147118910790290911","article-title":"The need to take a \u2018new look\u2019 at emergency contraception","volume":"36","author":"Cameron, S.; Glasier, A.","year":"2010","unstructured":"Cameron S, Glasier A. The need to take a \u2018new look\u2019 at emergency contraception. J Fam Plann Reprod Health Care 2010; 36: 3\u20134.","journal-title":"J Fam Plann Reprod Health Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1471-0528.2008.01787.x","article-title":"Using telemedicine for termination of pregnancy with mifepristone and misoprostol in settings where there is no access to safe services","volume":"115","author":"Gomperts, R.; Kleiverda, G.; Gemzell, K.; Davies, S.; Jelinska, K.","year":"2008","unstructured":"Gomperts R, Kleiverda G, Gemzell K, Davies S, Jelinska K. Using telemedicine for termination of pregnancy with mifepristone and misoprostol in settings where there is no access to safe services. Br J Obstet Gynaecol 2008; 115: 1171\u20131175.","journal-title":"Br J Obstet Gynaecol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1783\/147118909789587439","article-title":"Effect of self-triage on waiting times at a walk-in sexual health clinic","volume":"35","author":"Hitchings, S.; Barter, J.","year":"2009","unstructured":"Hitchings S, Barter J. Effect of self-triage on waiting times at a walk-in sexual health clinic. J Fam Plann Reprod Health Care 2009; 35: 227\u2013231.","journal-title":"J Fam Plann Reprod Health Care"},{"key":"ref_23","article-title":"Research Methods in Health: Investigating Health and Health Services","author":"Bowling, A.","year":"2002","unstructured":"Bowling A. Research Methods in Health: Investigating Health and Health Services. Buckingham, UK: Open University Press, 2002."},{"key":"ref_24","article-title":"I am puzzled by the new advice given by UKMEC. The references given in the 2009 guidelines","volume-title":"are very similar, to those in the 2006 guidelines. Why has the advice changed? I am aware of the paper in Contraception3 suggesting that both the COC and IUDs can be used in women with GTN. This paper also quotes some publications suggesting that COC use reduces the risk of women developing post molar trophoblastic disease, however it is not quoted by UKMEC","author":"all predate, and","year":"2009","unstructured":"I am puzzled by the new advice given by UKMEC. The references given in the 2009 guidelines all predate, and are very similar, to those in the 2006 guidelines. Why has the advice changed? I am aware of the paper in Contraception3 suggesting that both the COC and IUDs can be used in women with GTN. This paper also quotes some publications suggesting that COC use reduces the risk of women developing post molar trophoblastic disease, however it is not quoted by UKMEC 2009."}],"container-title":["Journal of Family Planning and Reproductive Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1783\/147118910791069394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:37:56Z","timestamp":1757101076000},"score":1,"resource":{"primary":{"URL":"https:\/\/jfprhc.bmj.com\/lookup\/doi\/10.1783\/147118910791069394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,4,1]]},"published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1783\/147118910791069394"],"URL":"https:\/\/doi.org\/10.1783\/147118910791069394","relation":{},"ISSN":["1471-1893","2045-2098"],"issn-type":[{"type":"print","value":"1471-1893"},{"type":"electronic","value":"2045-2098"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}