{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:10:37Z","timestamp":1790413837336,"version":"4.1.0"},"reference-count":40,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Fam Plann Reprod Health Care"],"accepted":{"date-parts":[[2010,5,31]]},"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The primary objective of the study was to clarify whether the use of the oral contraceptive 2 mg dienogest\/30 \u03bcg ethinylestradiol (DNG\/EE) is associated with a higher risk of venous thromboembolism (VTE) than the use of other combined oral low-dose contraceptives (i.e. containing \u226430 \u03bcg EE), particularly oral contraceptives containing levonorgestrel (LNG). The secondary objective was to investigate the VTE risk associated with drospirenone\/ethinylestradiol (DRSP\/EE) in comparison to low-dose LNG\/EE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This German community-based, case-control study recruited VTE cases from the primary care sector. Eligible cases were women aged 15\u201349 years with a VTE between January 2002 and February 2008. Four controls (women without a confirmed or potential VTE before the index date) were matched by age and region to each case. Medical information relevant for the assessment of VTE was abstracted from patient charts. Data on personal characteristics of the patients were collected via self-administered questionnaires. At the end of the study a blinded adjudication of the reported VTE was conducted. Conditional logistic regression techniques were used, adjusting for nine potential confounders, including personal history of VTE, family history of VTE, body mass index, duration of current combined oral contraceptive (COC) use and smoking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 680 VTE cases and 2720 corresponding controls were analysed. The mean age of cases and controls was \u2013 as a result of matching \u2013 almost identical (36.1 years). A total of 35, 25, and 60 of the cases had used DNG-, DRSP- and LNG-containing low-dose COCs, respectively, at the time of the VTE diagnosis. The crude odds ratio (OR) for VTE associated with current COC use in comparison to women who had never used a COC before the index date was 1.9 (95% CI 1.5\u20132.5), the adjusted OR was 2.3 (95% CI 1.7\u20133.0). The point estimate of the crude OR of DNG\/EE vs any other low-dose COCs was 0.9 (95% CI 0.6\u20131.3), the adjusted OR was 0.9 (95% CI 0.6\u20131.4). The crude ORs for DNG\/EE and DRSP\/EE vs low-dose LNG\/EE were 1.1 (95% CI 0.7\u20131.8) and 1.0 (95% CI 0.6\u20131.6), respectively; the adjusted ORs were 1.1 (95% CI 0.7\u20131.9) and 1.0 (95% CI 0.6\u20131.8).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The study confirms that COC use is associated with an increased risk of VTE. The VTE ORs (adjusted and crude) that compared DNG\/EE and DRSP\/EE with other low-dose COCs (including LNG\/EE) were close to unity and do not indicate a higher risk for users of DNG\/EE or DRSP\/EE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1783\/147118910791749416","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T19:36:20Z","timestamp":1278617780000},"page":"123-129","source":"Crossref","is-referenced-by-count":80,"title":["Risk of venous thromboembolism and the use of dienogest- and drospirenone-containing oral contraceptives: results from a German case-control study"],"prefix":"10.1136","volume":"36","author":[{"given":"J\u00fcrgen","family":"Dinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Assmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"M\u00f6hner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thai Do","family":"Minh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(95)91927-9","article-title":"World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. 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Venous thromboembolism and oral contraceptive use: a methodological study of diagnostic suspicion and referral bias. Eur J Contracept Reprod Health Care 2000; 5: 183\u2013191.","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"ref_39","article-title":"The Immigrant. Manju Kapur","author":"-","year":"2009","unstructured":"The Immigrant. Manju Kapur. London, UK: Faber & Faber, 2009. ISBN-13: 978-0-57124-4072. Price: \u00a37.99. Pages: 352 (paperback)"},{"key":"ref_40","article-title":"We hope that journal readers enjoyed reading The Immigrant, and also discovering whether their opinion of this book matched that of our guest reviewer. In the October 2010 issue, the fiction book under scrutiny will be Private Life by Jane","volume-title":"12.99, paperback). We also hope to review two other books that Journal readers might be interested in reading: Antigona and Me by Kate Clanchy (273 pages, Picador, ISBN13: 978-0-33044-933-5, \u00a37,99. paperback) and Daughter of Dust: Growing Up an Outcast in the Desert of Sudan by Wendy","author":"-","year":"2010","unstructured":"We hope that journal readers enjoyed reading The Immigrant, and also discovering whether their opinion of this book matched that of our guest reviewer. In the October 2010 issue, the fiction book under scrutiny will be Private Life by Jane Smiley (318 pages, Faber & Faber, 2010, ISBN-13: 978-0-571-25874-1, \u00a312.99, paperback). We also hope to review two other books that Journal readers might be interested in reading: Antigona and Me by Kate Clanchy (273 pages, Picador, ISBN13: 978-0-33044-933-5, \u00a37,99. paperback) and Daughter of Dust: Growing Up an Outcast in the Desert of Sudan by Wendy Wallace (304 pages, Pocket Books, 2010, ISBN-13: 978-1847396358, \u00a37,99. paperback). We want to remind journal readers that if they would like to offer to review an appropriate fiction title of their own choosing then they should contact the Journal Editorial Office by e-mail (journal@fsrh.org) in the first instance with details of their nominated title."}],"container-title":["Journal of Family Planning and Reproductive Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1783\/147118910791749416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T18:53:23Z","timestamp":1757098403000},"score":1,"resource":{"primary":{"URL":"https:\/\/jfprhc.bmj.com\/lookup\/doi\/10.1783\/147118910791749416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,7,1]]},"published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1783\/147118910791749416"],"URL":"https:\/\/doi.org\/10.1783\/147118910791749416","relation":{},"ISSN":["1471-1893","2045-2098"],"issn-type":[{"value":"1471-1893","type":"print"},{"value":"2045-2098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}