{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:32:38Z","timestamp":1770352358210,"version":"3.49.0"},"reference-count":107,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Fam Plann Reprod Health Care"],"accepted":{"date-parts":[[2010,7,27]]},"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:p>The past 50 years have seen great advances in combined oral contraceptives (COCs) that have resulted in reduced risks of adverse events and improved cycle control. The most important changes in COCs over time include repeated lowering of the estrogen dose, development of new progestogens, and the reduction or elimination of the pill-free interval. Most recently, formulations that deliver estradiol in lieu of ethinylestradiol have been introduced. The advantages of COCs generally far outweigh the disadvantages. Current options in oral contraception include a wide spectrum of products that enable clinicians to choose the most appropriate formulation for individual women. This article summarises the advances in oral contraceptives over time and describes the most current clinical data regarding the use of COCs.<\/jats:p>","DOI":"10.1783\/147118910793048665","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T05:54:48Z","timestamp":1297403688000},"page":"231-238","source":"Crossref","is-referenced-by-count":28,"title":["50 years of \u201cThe Pill\u201d: celebrating a golden anniversary"],"prefix":"10.1136","volume":"36","author":[{"given":"Anne","family":"Szarewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee P","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"ref_1","article-title":"Social Affairs Population Division. 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The new Part 2 Syllabus is on the Faculty website."},{"key":"ref_107","article-title":"For the current MFSRH Examination Regulations, information on all components of the MFSRH examination and application forms, please visit the Faculty of Sexual and Reproductive Healthcare website: www.fsrh.org (Training & Exams and Membership Exam) or e-mail Denise","unstructured":"For the current MFSRH Examination Regulations, information on all components of the MFSRH examination and application forms, please visit the Faculty of Sexual and Reproductive Healthcare website: www.fsrh.org (Training & Exams and Membership Exam) or e-mail Denise Pickford: denise@fsrh.org."}],"container-title":["Journal of Family Planning and Reproductive Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1783\/147118910793048665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T18:53:47Z","timestamp":1757098427000},"score":1,"resource":{"primary":{"URL":"https:\/\/jfprhc.bmj.com\/lookup\/doi\/10.1783\/147118910793048665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,1]]},"references-count":107,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,10,1]]},"published-print":{"date-parts":[[2010,10,1]]}},"alternative-id":["10.1783\/147118910793048665"],"URL":"https:\/\/doi.org\/10.1783\/147118910793048665","relation":{},"ISSN":["1471-1893","2045-2098"],"issn-type":[{"value":"1471-1893","type":"print"},{"value":"2045-2098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,1]]}}}