{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:38:58Z","timestamp":1771231138490,"version":"3.50.1"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objetivo: El objetivo del estudio fue analizar la expresi\u00f3n diferencial de miR-21, miR-29a, miR-99b y miR-155 en muestras de suero de pacientes con tuberculosis (TB) latente y TB activa respecto a controles sanos. Materiales y m\u00e9todos: Se utilizaron 28 muestras de suero (nueve con TB activa, diez con TB latente y nueve controles sanos) para el an\u00e1lisis de expresi\u00f3n g\u00e9nica mediante RT-qPCR con Primers y sondas TaqMan. Se calcul\u00f3 la expresi\u00f3n diferencial por el m\u00e9todo de Livak utilizando un gen normalizador (RNU-48). Resultados: Se hall\u00f3 una sobreexpresi\u00f3n de miR-155 en personas con tuberculosis latente, respecto a los controles sanos (0,63 vs. 0,01; valor de p=0,032). Conclusi\u00f3n: El miR-155 podr\u00eda ser considerado un biomarcador para diferenciar TB latente de enfermedad activa. Se requieren estudios con mayores tama\u00f1os muestrales para corroborar nuestros hallazgos.<\/jats:p>","DOI":"10.17843\/rpmesp.2020.371.4468","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:45:28Z","timestamp":1588959928000},"page":"51-6","source":"Crossref","is-referenced-by-count":11,"title":["Expresi\u00f3n diferencial de micro-ARN circulantes en pacientes con tuberculosis activa y latente"],"prefix":"10.17843","volume":"37","author":[{"given":"Jose","family":"Yareta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Galarza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Capristano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Pell\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Ballon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinner","family":"Guio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2020,3,24]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/4468\/3520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/4468\/3520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:45:35Z","timestamp":1588959935000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/4468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,24]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,3,24]]}},"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2020.371.4468","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,24]]}}}