{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:06:39Z","timestamp":1793325999477,"version":"4.5.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objetivos: Relacionar entre s\u00ed los eventos histopatol\u00f3gicos de malaria placentaria (MP), el comportamiento de c\u00e9lulas inmunitarias y la expresi\u00f3n de genes asociados a citoquinas, hipoxia, inflamaci\u00f3n y angiog\u00e9nesis en placentas con o sin infecci\u00f3n plasmodial. Materiales y m\u00e9todos: Dise\u00f1o transversal, con tres grupos independientes. Las mujeres y sus placentas fueron captadas en 2009-2016, en los hospitales de Puerto Libertador y Tierralta, noroccidente de Colombia. El tama\u00f1o muestral se defini\u00f3 por conveniencia. El diagn\u00f3stico mal\u00e1rico se bas\u00f3 en PCR cuantitativa en tiempo real. Resultados: Se estudiaron 20 casos con MP por P. vivax (MP-V), 20 casos de MP por P. falciparum (MP-F) y 19 sin MP; 95% de los casos de MP son infecci\u00f3n plasmodial placentaria submicrosc\u00f3pica (IPPS). Los tres grupos difieren en frecuencia y cantidad de eventos histopatol\u00f3gicos. Los mediadores de procesos fisiol\u00f3gicos presentaron diferencia significativa entre grupos, excepto IL-2, VEGF, VEGFR-1 y C5a. Conclusiones: Las placentas con infecci\u00f3n difieren claramente de las no infectadas. P. vivax se comporta tan pat\u00f3geno como P. falciparum. Se resalta la aproximaci\u00f3n al abordaje integral del problema de MP. La infecci\u00f3n plasmodial placentaria submicrosc\u00f3pica causa alteraciones tisulares y en mediadores fisiol\u00f3gicos como lo hace la infecci\u00f3n microsc\u00f3pica, aunque probablemente en menor grado.<\/jats:p>","DOI":"10.17843\/rpmesp.2020.372.4759","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T02:45:45Z","timestamp":1593830745000},"page":"220-8","source":"Crossref","is-referenced-by-count":10,"title":["Malaria placentaria submicrosc\u00f3pica: histopatolog\u00eda y expresi\u00f3n de mediadores de procesos fisiol\u00f3gicos"],"prefix":"10.17843","volume":"37","author":[{"given":"Carolina","family":"L\u00f3pez-Guzm\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Carmona-Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2020,6,17]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/4759\/3654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/4759\/3654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T02:45:51Z","timestamp":1593830751000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/4759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,4,21]]}},"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2020.372.4759","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,17]]}}}