{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:24:06Z","timestamp":1787023446181,"version":"build-2736575974"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objetivo: Determinar la incidencia y las caracter\u00edsticas cl\u00ednicas, bacteriol\u00f3gicas y del l\u00edquido cefalorraqu\u00eddeo de la meningitis neonatal en hospitales de Lima. Materiales y m\u00e9todos: Se realiz\u00f3 un estudio observacional, multic\u00e9ntrico en seis hospitales de la ciudad de Lima, con una vigilancia epidemiol\u00f3gica durante un a\u00f1o. Resultados: La incidencia acumulada hospitalaria fue de 1,4 casos por mil nacidos vivos. Fueron incluidos 53 casos de meningitis neonatal, 34% (18\/53) fueron tempranos y 66% (35\/53) tard\u00edos. Los factores maternos asociados fueron l\u00edquido amni\u00f3tico meconial e infecci\u00f3n de tracto urinario. El 58,8% (30\/51) present\u00f3 controles prenatales insuficientes. El factor neonatal m\u00e1s asociado fue sepsis. Los principales s\u00edntomas fueron fiebre, irritabilidad, hipoactividad y dificultad respiratoria. En el l\u00edquido cefalorraqu\u00eddeo (LCR) se destac\u00f3 la pleocitosis, sin predominio de polimorfonucleares (PMN), hipoglucorraquia y proteinorraquia. Los pat\u00f3genos aislados con mayor frecuencia fueron Escherichia coli y Listeria monocytogenes. Conclusiones: La incidencia hospitalaria de meningitis neonatal fue de 1,4 por mil nacidos vivos, siendo diez veces mayor en prematuros. La dificultad respiratoria fue el s\u00edntoma m\u00e1s frecuente en la forma temprana, mientras que la fiebre e irritabilidad en la forma tard\u00eda. El LCR mostr\u00f3 pleocitosis sin predominio de PMN. Los g\u00e9rmenes m\u00e1s frecuentes fueron Escherichia coli y Listeria monocytogenes. La ventriculitis e hidrocefalia fueron las complicaciones neurol\u00f3gicas m\u00e1s comunes.<\/jats:p>","DOI":"10.17843\/rpmesp.2020.372.4772","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T22:45:45Z","timestamp":1593816345000},"page":"210-9","source":"Crossref","is-referenced-by-count":11,"title":["Meningitis neonatal: estudio multic\u00e9ntrico en Lima, Per\u00fa"],"prefix":"10.17843","volume":"37","author":[{"given":"Daniel","family":"Guill\u00e9n-Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"M\u00e1laga-Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joselyn","family":"Ye-Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luz","family":"Rospigliosi-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Montenegro-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Stiglich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5378-1822","authenticated-orcid":false,"given":"Sonia","family":"Villasante-Valera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Lizama-Olaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Tori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizet","family":"Cuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Flori\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leidi","family":"Vilchez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Eguiluz-Loaiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Rosa","family":"D\u00e1vila-Aliaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Medina-Alva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2020,6,15]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/4772\/3633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/4772\/3633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T22:45:52Z","timestamp":1593816352000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/4772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,4,21]]}},"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2020.372.4772","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,15]]}}}