{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:31:03Z","timestamp":1772087463194,"version":"3.50.1"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>La pandemia de COVID-19 ha tra\u00eddo una nueva afecci\u00f3n grave e inusual denominada S\u00edndrome Inflamatorio Multisist\u00e9mico en ni\u00f1os, de la cual a\u00fan hay mucho por conocer. Presentamos una serie de 8 casos atendidos en el Instituto Nacional de Salud del Ni\u00f1o, Lima Per\u00fa. La edad media fue 5,1 a\u00f1os. La presentaci\u00f3n cl\u00ednica incluy\u00f3 fiebre, problemas gastrointestinales agudos, afectaci\u00f3n ocular y mucocut\u00e1nea. Cuatro cumplieron criterios para Enfermedad de Kawasaki cl\u00e1sica. Todos tuvieron serolog\u00eda positiva para SARS-CoV-2, hemograma patol\u00f3gico, marcadores inflamatorios elevados y pruebas de coagulaci\u00f3n alteradas. Cinco casos presentaron hipertransaminasemia y tres retenci\u00f3n nitrogenada. Cuatro casos cumplieron criterios para S\u00edndrome de Activaci\u00f3n Macr\u00f3fagica. Todos recibieron inmunoglobulina intravenosa, corticoides y \u00e1cido acetil salic\u00edlico. Ninguno desarroll\u00f3 aneurismas coronarios. Solo uno present\u00f3 miocarditis, shock y requiri\u00f3 ingreso a Unidad de Cuidados Intensivos. La mayor\u00eda evolucionaron favorablemente. En todo ni\u00f1o con fiebre, s\u00edntomas gastrointestinales y dermatol\u00f3gicos; asociado a exposici\u00f3n al SARS-CoV-2, debe investigarse compromiso multisist\u00e9mico.<\/jats:p>","DOI":"10.17843\/rpmesp.2020.373.6126","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T21:09:33Z","timestamp":1601586573000},"page":"559-65","source":"Crossref","is-referenced-by-count":15,"title":["S\u00edndrome inflamatorio multisist\u00e9mico asociado a COVID-19 en ni\u00f1os: serie de casos en un hospital pedi\u00e1trico de Per\u00fa"],"prefix":"10.17843","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8709-397X","authenticated-orcid":false,"given":"Liz E.","family":"De Coll-Vela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3451-0629","authenticated-orcid":false,"given":"Mariela K.","family":"Zamudio-Aquise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-2079","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Nu\u00f1ez-Paucar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-7284","authenticated-orcid":false,"given":"Ra\u00fal R.","family":"Bernal-Mancilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9189-7778","authenticated-orcid":false,"given":"Sandra C.","family":"Schult-Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8625-5922","authenticated-orcid":false,"given":"Manuel","family":"Ccorahua-De La Paz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-1533","authenticated-orcid":false,"given":"Cynthia L.","family":"Huby-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1103-2780","authenticated-orcid":false,"given":"Carlos F.","family":"Castillo-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6529-8459","authenticated-orcid":false,"given":"Jorge L.","family":"Candela-Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5381-4329","authenticated-orcid":false,"given":"Franklin","family":"Aranda-Paniora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6196-7758","authenticated-orcid":false,"given":"Ra\u00fal A.","family":"Rojas-Galarza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2020,9,24]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/6126\/3771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/6126\/3771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T21:10:07Z","timestamp":1601586607000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/6126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,9,24]]}},"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2020.373.6126","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,24]]}}}