{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:17:22Z","timestamp":1794367042002,"version":"4.9.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objetivo: Describir los resultados de los ex\u00e1menes de laboratorio realizados en muestras biol\u00f3gicas de pacientescon s\u00edndrome de Guillain-Barr\u00e9 (SGB), recibidas en el Instituto Nacional de Salud (INS) entre los a\u00f1os 2018y 2019. Materiales y m\u00e9todos: Se realiz\u00f3 un estudio observacional en pacientes con SGB notificados en elsistema de vigilancia epidemiol\u00f3gica. Se obtuvieron muestras biol\u00f3gicas analizadas en el INS para investigararbovirus, virus respiratorios, enterovirus y enterobacterias, entre otros. Resultados: Se recibi\u00f3 un total de2051 espec\u00edmenes cl\u00ednicos de 906 pacientes con SGB. Tres pacientes dieron positivo al dengue y tres pacientesal Zika. En 19 pacientes, el cultivo en heces fue positivo para Campylobacter jejuni. El an\u00e1lisis filogen\u00e9tico dediez cepas de Campylobacter jejuni las clasific\u00f3 como genotipo ST2993, reportado previamente en China yasociado a un brote de SGB. En 2018, hubo 12 muestras que hab\u00edan dado positivo al PCR para enterovirus enel l\u00edquido cefalorraqu\u00eddeo, pero ninguna pudo corroborarse con el cultivo respectivo ni con secuenciamientode genoma completo. Un paciente dio positivo por virus de la influenza A, dos por virus de la influenza B, dospor adenovirus, cinco por virus respiratorio sincicial, y diez por rinovirus. Conclusi\u00f3n: Se han encontradodiversos agentes pat\u00f3genos en espec\u00edmenes de pacientes con SGB, sin embargo, la presencia de Campylobacterjejuni genotipo ST2993, un pat\u00f3geno relacionado a brotes de SGB en varios continentes, ser\u00eda el probable agentecausal. Es necesario confirmar esta hip\u00f3tesis con estudios anal\u00edticos y determinar la cadena de transmisi\u00f3n deeste agente para implementar las medidas de prevenci\u00f3n y control.<\/jats:p>","DOI":"10.17843\/rpmesp.2020.374.5169","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:51:26Z","timestamp":1609793486000},"page":"681-8","source":"Crossref","is-referenced-by-count":8,"title":["Agentes infecciosos en muestras biol\u00f3gicas de pacientes con s\u00edndrome de Guillain-Barr\u00e9 en Per\u00fa, 2018-2019"],"prefix":"10.17843","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-0600","authenticated-orcid":false,"given":"Paul","family":"Pachas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4456-4946","authenticated-orcid":false,"given":"Fernando","family":"Donaires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-5607","authenticated-orcid":false,"given":"Ronnie G.","family":"Gavil\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1531","authenticated-orcid":false,"given":"Willi","family":"Quino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1459-6314","authenticated-orcid":false,"given":"Margot","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5120-0713","authenticated-orcid":false,"given":"C\u00e9sar","family":"Cabezas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2185-5038","authenticated-orcid":false,"given":"Mar\u00eda","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-4040","authenticated-orcid":false,"given":"Maribel","family":"Huaringa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-8868","authenticated-orcid":false,"given":"Flor","family":"Peceros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8347-6853","authenticated-orcid":false,"given":"Faviola","family":"Valdivia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-8807","authenticated-orcid":false,"given":"Lely","family":"Solari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2020,11,18]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/5169\/3824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/5169\/3824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:51:38Z","timestamp":1609793498000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/5169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,8,21]]}},"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2020.374.5169","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,18]]}}}