{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:02:46Z","timestamp":1770278566780,"version":"3.49.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Con el objetivo de describir las caracter\u00edsticas gen\u00f3micas relacionadas con la resistencia antimicrobianay gen\u00f3mica comparativa de Escherichia coli diarreog\u00e9nica (DEC), se sometieron a secuenciamientogen\u00f3mico catorce aislamientos de DEC del banco de cepas del Instituto Nacional de Salud (INS). Lassecuencias obtenidas se analizaron mediante procedimientos bioinform\u00e1ticos a fin de buscar genes de resistenciamicrobiana y regiones gen\u00e9ticas relacionadas con patotipos y filogrupos. Se detectaron diversosdeterminantes de resistencia antimicrobiana, se destaca la producci\u00f3n de betalactamasas y mutacionesasociadas a la resistencia a quinolonas. Adem\u00e1s, se observaron aislamientos de un mismo patotipo agrupadosen distintos filogrupos. El an\u00e1lisis de gen\u00f3mica comparativa mostr\u00f3 un mayor n\u00famero de genesort\u00f3logos en aislamientos que pertenec\u00edan al mismo patotipo y filogrupo. Sobre la base de lo estudiado,los aislamientos de DEC en Lima, Per\u00fa, presentan resistencia a m\u00faltiples f\u00e1rmacos, y se detectaron variospatotipos y filogrupos con diversidad molecular y filogen\u00e9tica.<\/jats:p>","DOI":"10.17843\/rpmesp.2020.374.5240","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:51:26Z","timestamp":1609793486000},"page":"705-10","source":"Crossref","is-referenced-by-count":2,"title":["Resistoma y gen\u00f3mica comparativa de aislados cl\u00ednicos de Escherichia coli diarreog\u00e9nica en Lima, Per\u00fa"],"prefix":"10.17843","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1531","authenticated-orcid":false,"given":"Willi","family":"Quino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7268-0496","authenticated-orcid":false,"given":"Orson","family":"Mestanza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-6119","authenticated-orcid":false,"given":"Junior","family":"Caro-Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3667-6806","authenticated-orcid":false,"given":"Carmen Ver\u00f3nica","family":"Hurtado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-5607","authenticated-orcid":false,"given":"Ronnie G.","family":"Gavil\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2020,11,18]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/5240\/3826","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/5240\/3827","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/5240\/3827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:51:41Z","timestamp":1609793501000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/5240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,8,21]]}},"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2020.374.5240","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,18]]}}}