{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T14:49:40Z","timestamp":1771080580151,"version":"3.50.1"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>El objetivo del estudio fue evaluar los niveles y mecanismos de resistencia a la colistina y a los carbapen\u00e9micos en cepas de Klebsiella pneumoniae multidrogorresistente aisladas durante el periodo 2015-2018 en el Instituto Materno Perinatal de Lima. Se analiz\u00f3 la sensibilidad mediante difusi\u00f3n en disco y microdiluci\u00f3n. La presencia de genes de resistencia a los carbapen\u00e9micos y a la colistina se determin\u00f3 por reacci\u00f3n en cadena de la polimerasa (PCR, por sus siglas en ingl\u00e9s) y se la relacion\u00f3 con la clonalidad. Se analizaron 36 cepas de K. pneumoniae, cinco (13,8%) fueron resistentes a la colistina, pertenec\u00edan a diferentes grupos clonales. Se encontraron dos cepas con carbapenemasas (blaKPC y blaNDM) y no se detectaron genes plasm\u00eddicos para la colistina. Los niveles de resistencia al resto de antimicrobianos testados fueron elevados, a excepci\u00f3n de amikacina (13,9%). Los resultados destacan la presencia de cepas resistentes a la colistina (33,3% en 2018), situaci\u00f3n preocupante por ser esta parte de las \u00faltimas alternativas de tratamiento para las infecciones causadas por pat\u00f3genos multirresistentes<\/jats:p>","DOI":"10.17843\/rpmesp.2020.374.5422","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:51:26Z","timestamp":1609793486000},"page":"716-20","source":"Crossref","is-referenced-by-count":8,"title":["Resistencia a colistina en cepas de Klebsiella pneumoniae multidrogorresistente del per\u00edodo 2015- 2018 en un hospital materno perinatal de Lima, Per\u00fa"],"prefix":"10.17843","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0954-9561","authenticated-orcid":false,"given":"Andrea","family":"Naomi-Matsuoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-8118","authenticated-orcid":false,"given":"Marina","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-9243","authenticated-orcid":false,"given":"Barbara","family":"Yma\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5159-2817","authenticated-orcid":false,"given":"Gabriela","family":"Soza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8384-2315","authenticated-orcid":false,"given":"Maria J.","family":"Pons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2020,10,6]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/5422\/3778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/5422\/3778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:51:47Z","timestamp":1609793507000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/5422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,6]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,8,21]]}},"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2020.374.5422","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,6]]}}}