{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:36:21Z","timestamp":1747200981016,"version":"3.40.5"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Actualmente no existe vacuna disponible ni medicaci\u00f3n espec\u00edfica contra la enfermedad por coronavirus 2019 (COVID-19). El tratamiento se basa fundamentalmente en medidas de soporte. En este contexto, se han aprobado m\u00faltiples terapias de potencial utilidad para su uso en ensayos cl\u00ednicos, como la transfusi\u00f3n de plasma convaleciente (TPC). Se realiz\u00f3 una b\u00fasqueda en PubMed de estudios sobre plasma convaleciente y COVID- 19, SARS o MERS. Los estudios sobre la eficacia cl\u00ednica en enfermedades causadas por otros coronavirus (SARS-CoV y MERS-CoV) evidenciaron mejor\u00eda cl\u00ednica, aumento de anticuerpos neutralizantes, disminuci\u00f3n de la mortalidad y ausencia de eventos adversos durante y despu\u00e9s del tratamiento. En el caso de la COVID-19, se encontraron 13 estudios en pacientes con la COVID-19 grave y cr\u00edtica. Aunque existen limitaciones en la metodolog\u00eda, en el n\u00famero de pacientes y en los protocolos para el an\u00e1lisis del plasma convaleciente de los donantes, los pacientes que recibieron TPC evidenciaron mejor\u00eda cl\u00ednica, mejor\u00eda de patrones ventilatorios, resoluci\u00f3n de lesiones pulmonares, disminuci\u00f3n de mortalidad, mejor\u00eda de par\u00e1metros laboratoriales, aumento de anticuerpos neutralizantes, disminuci\u00f3n de carga viral y baja frecuencia de eventos adversos.<\/jats:p>","DOI":"10.17843\/rpmesp.2020.374.5767","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:51:26Z","timestamp":1609793486000},"page":"746-54","source":"Crossref","is-referenced-by-count":0,"title":["Transfusi\u00f3n de plasma convaleciente de pacientes con COVID-19"],"prefix":"10.17843","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-3051","authenticated-orcid":false,"given":"C\u00e9sar A.","family":"Galv\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3198-5549","authenticated-orcid":false,"given":"Crhistian","family":"Toribio-Dionicio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-4826","authenticated-orcid":false,"given":"Marco","family":"\u00c1lvarez-\u00c1ngeles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-307X","authenticated-orcid":false,"given":"Oscar","family":"Alama-Baz\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-7948","authenticated-orcid":false,"given":"Luis","family":"S\u00e1nchez-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2020,11,9]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/5767\/3817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/5767\/3817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:51:53Z","timestamp":1609793513000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/5767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,9]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,8,21]]}},"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2020.374.5767","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"type":"electronic","value":"1726-4642"},{"type":"print","value":"1726-4634"}],"subject":[],"published":{"date-parts":[[2020,11,9]]}}}