{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:03:08Z","timestamp":1792040588328,"version":"4.4.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>El presente reporte es la descripci\u00f3n original de blaTEM-176. Se caracterizaron los mecanismos de resistencia a antimicrobianos de un aislamiento de Escherichia coli enterotoxig\u00e9nica, determin\u00e1ndose la resistencia a 22 antimicrobianos categorizados en 15 grupos diferentes mediante difusi\u00f3n en agar, estableci\u00e9ndose grupo filogen\u00e9tico, mecanismos de resistencia y presencia de integrones de Clase 1 y 2 mediante PCR. Integrones y genes de resistencia a \u03b2-lact\u00e1micos fueron secuenciados. El aislamiento del grupo filogen\u00e9tico A, mostr\u00f3 resistencia o sensibilidad disminuida a ampicilina, amoxicilina m\u00e1s \u00e1cido clavul\u00e1nico, \u00e1cido nalid\u00edxico, ciprofloxacino, estreptomicina, kanamicina, tetraciclina, trimetoprim, sulfisoxazol, cotrimoxazol, azitromicina y nitrofurantoina, detect\u00e1ndose la presencia de blaTEM, aadA1\/2, aphA1, sul3, tet(A) y un integron de Clase 2 conteniendo un gen dfrA1. La resistencia a quinolonas se relacion\u00f3 con la substituci\u00f3n Ser83Ala. La secuencia de TEM mostr\u00f3 la substituci\u00f3n Ala222Val, la cual a la fecha no hab\u00eda sido descrita, report\u00e1ndose como una nueva \u03b2-lactamasa, con el nombre de blaTEM-176.<\/jats:p>","DOI":"10.17843\/rpmesp.2021.381.6727","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T21:07:34Z","timestamp":1620767254000},"page":"130-5","source":"Crossref","is-referenced-by-count":5,"title":["Caracterizaci\u00f3n de Escherichia coli D7111 productora de \u03b2-lactamasa TEM-176"],"prefix":"10.17843","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4431-2036","authenticated-orcid":false,"given":"Joaquim","family":"Ruiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8384-2315","authenticated-orcid":false,"given":"Maria J.","family":"Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-1820","authenticated-orcid":false,"given":"Susan","family":"Mosquito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3227-3906","authenticated-orcid":false,"given":"Theresa J.","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-4258","authenticated-orcid":false,"given":"Yolanda","family":"S\u00e1enz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2021,3,26]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/6727\/3968","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/6727\/4168","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/6727\/4168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T21:08:27Z","timestamp":1620767307000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/6727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3,26]]}},"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2021.381.6727","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,26]]}}}