{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:24:55Z","timestamp":1781583895293,"version":"3.54.5"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>El prop\u00f3sito del presente estudio fue describir las caracter\u00edsticas epidemiol\u00f3gicas, cl\u00ednicas, y terap\u00e9uticas de pacientes con diagn\u00f3stico de toxoplasmosis cong\u00e9nita (TC) con enfermedad neurol\u00f3gica severa. Se revisaron las historias cl\u00ednicas de los pacientes menores de 1 a\u00f1o con serolog\u00eda IgM positiva para Toxoplasma gondii y compromiso encef\u00e1lico, ocular y\/o auditivo. El estudio se realiz\u00f3 en el Instituto Nacional de Salud del Ni\u00f1o San Borja (INSN-SB) en Lima, Per\u00fa. Se evaluaron a 21 pacientes con diagn\u00f3stico de TC, el 57,1% fueron del sexo femenino y la mediana de edad al momento del diagn\u00f3stico fue 3,1 meses (RIC: 1,7-7,3). Las principales manifestaciones del sistema nervioso central fueron hidrocefalia (76,2%), calcificaciones intracraneales (52,4%), microcefalia (42,9%), y convulsiones (25,6%); la manifestaci\u00f3n ocular m\u00e1s frecuente fue la coriorretinitis (38,1%). En conclusi\u00f3n, 64% de los casos de TC tuvieron una o m\u00e1s manifestaciones de enfermedad neurol\u00f3gica severa.<\/jats:p>","DOI":"10.17843\/rpmesp.2022.392.10897","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T15:21:37Z","timestamp":1659972097000},"page":"208-13","source":"Crossref","is-referenced-by-count":6,"title":["Toxoplasmosis cong\u00e9nita con enfermedad neurol\u00f3gica severa en un hospital de referencia del Per\u00fa"],"prefix":"10.17843","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-8343","authenticated-orcid":false,"given":"Julio","family":"Maquera-Afaray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-7877","authenticated-orcid":false,"given":"Medalit","family":"Luna-Vilchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9667-5376","authenticated-orcid":false,"given":"Blanca","family":"Salazar-Mesones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6547-9882","authenticated-orcid":false,"given":"Christian","family":"Chiara-Chilet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-9072","authenticated-orcid":false,"given":"Alexander","family":"Cordero-Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-7284","authenticated-orcid":false,"given":"Jos\u00e9 W.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2022,7,8]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/10897\/4923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/10897\/4964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/viewFile\/10897\/4964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T15:21:53Z","timestamp":1659972113000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/10897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,8]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,7,6]]}},"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2022.392.10897","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,8]]}}}