{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:36:30Z","timestamp":1747200990815,"version":"3.40.5"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objetivo. Explorar la viabilidad de desarrollar un modelo de neurocisticercosis (NCC) de oveja mediante\u00a0infecci\u00f3n intracraneal de oncosferas de T. solium. Materiales y m\u00e9todos. Se realiz\u00f3 un modelo de infecci\u00f3n experimental de NCC en ovejas. Se inocularon aproximadamente 10 posonc\u00f3sferas de T. solium cultivadas previamente por 30 d\u00edas por v\u00eda intracraneal en diez ovejas. Las onc\u00f3sferas, en 0,1 mL de soluci\u00f3n salina fisiol\u00f3gica, se inyectaron en el l\u00f3bulo parietal a trav\u00e9s de una aguja de calibre 18. Resultados. Despu\u00e9s de tres meses, en dos ovejas se encontraron granulomas y en una tercera identific\u00f3 un quiste de 5 mm de di\u00e1metro en el ventr\u00edculo lateral derecho y la evaluaci\u00f3n histol\u00f3gica confirm\u00f3 que el quiste corresponde a una larva de T. solium. Tambi\u00e9n se utiliz\u00f3 inmunohistoqu\u00edmica con anticuerpos monoclonales dirigidos contra componentes de membrana y ant\u00edgenos excretorios\/secretorios del quiste de T. solium para confirmar la etiolog\u00eda de los granulomas encontrados. Uno de ellos mostro reactividad ante los anticuerpos monoclonales utilizados, confirmando as\u00ed que se trat\u00f3 de un cisticerco Conclusi\u00f3n. Este experimento es la prueba de concepto de que es posible infectar ovejas con cisticercosis por inoculaci\u00f3n intracraneal.<\/jats:p>","DOI":"10.17843\/rpmesp.2022.393.11039","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T23:39:58Z","timestamp":1667777998000},"page":"328-35","source":"Crossref","is-referenced-by-count":1,"title":["Infecci\u00f3n experimental cerebral con cisticercosis en ovejas"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8336-340X","authenticated-orcid":false,"given":"Katherine A.","family":"Sota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5797-3052","authenticated-orcid":false,"given":"Javier A.","family":"Bustos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-1353","authenticated-orcid":false,"given":"Manuela R.","family":"Verastegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-4521","authenticated-orcid":false,"given":"Luz","family":"Toribio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-8118","authenticated-orcid":false,"given":"Nancy","family":"Chile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-5145","authenticated-orcid":false,"given":"Noelia","family":"Angulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3525-8445","authenticated-orcid":false,"given":"Carla","family":"Cangalaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4464-3107","authenticated-orcid":false,"given":"Juan","family":"Calcina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9198-6981","authenticated-orcid":false,"given":"Armando E.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3704-9217","authenticated-orcid":false,"given":"Robert H.","family":"Gilman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4633-6269","authenticated-orcid":false,"given":"H\u00e9ctor H.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2022,9,30]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11039\/5121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11039\/5121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T23:40:17Z","timestamp":1667778017000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/11039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2022.393.11039","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"type":"electronic","value":"1726-4642"},{"type":"print","value":"1726-4634"}],"subject":[],"published":{"date-parts":[[2022,9,30]]}}}