{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:36:31Z","timestamp":1747200991543,"version":"3.40.5"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objetivos. Evaluar la variaci\u00f3n de los perfiles hematol\u00f3gicos antes, durante y despu\u00e9s del tratamiento de pacientes infectados con malaria no complicada por Plasmodium vivax (Pv) y P. falciparum (Pf) en una poblaci\u00f3n de la regi\u00f3n Loreto. Materiales y m\u00e9todos. El estudio se realiz\u00f3 entre 2010 y 2012, en Zungarococha (Iquitos). Los 425 participantes tuvieron tres visitas (visita 1-d\u00eda 0-antes del tratamiento, visita 2-d\u00eda 7-durante tratamiento, visita 3-d\u00eda 28-despu\u00e9s del tratamiento), hemograma completo, diagn\u00f3stico microsc\u00f3pico y molecular (PCR). Resultados. En la primera visita, se encontraron 93 (21,9%) positivos a Pv y 34 (8,0%) a Pf. Todos los positivos mostraron una reducci\u00f3n en los indicadores hematol\u00f3gicos de hematocrito, recuento de gl\u00f3bulos blancos (RGB), neutr\u00f3filos abastonados y segmentados, eosin\u00f3filos y plaquetas (p&lt;0.001) en comparaci\u00f3n con el grupo negativo. Se encontr\u00f3 un porcentaje mayor de neutr\u00f3filos abastonados en Pf y de neutr\u00f3filos segmentados en Pv comparado al grupo negativo. Se observ\u00f3 variaciones en los perfiles\u00a0 hematol\u00f3gicos despu\u00e9s del tratamiento para ambas especies, los neutr\u00f3filos abastonados disminuyeron, las plaquetas aumentaron, los eosin\u00f3filos se incrementaron al d\u00eda 7 y decaen el d\u00eda 28, el hematocrito y los neutr\u00f3filos segmentados disminuyeron al d\u00eda 7 y se normalizaronel d\u00eda 28. Las diferencias entre especies en el tiempo mostraron una disminuci\u00f3n diaria de neutr\u00f3filos abastonados en infectados con Pv que en Pf. Conclusiones. El perfil hematol\u00f3gico en pacientes positivos a malaria no complicada var\u00eda en el tiempo durante y despu\u00e9s del tratamiento. Estos son indicadores de la progresi\u00f3n de la enfermedad y ayudan en la vigilancia terap\u00e9utica de pacientes infectados con Plasmodium.<\/jats:p>","DOI":"10.17843\/rpmesp.2022.393.11908","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T23:39:58Z","timestamp":1667777998000},"page":"336-44","source":"Crossref","is-referenced-by-count":0,"title":["Perfiles hematol\u00f3gicos en pacientes infectados con malaria en un \u00e1rea end\u00e9mica del Per\u00fa"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-563X","authenticated-orcid":false,"given":"Viviana","family":"Pinedo-Cancino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1890-9314","authenticated-orcid":false,"given":"Katty M.","family":"Arista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7779-481X","authenticated-orcid":false,"given":"Andree","family":"Valle-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6849-3794","authenticated-orcid":false,"given":"Rafael","family":"Saavedra-Langer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2522-0360","authenticated-orcid":false,"given":"Cristian","family":"Roca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-9867","authenticated-orcid":false,"given":"Jos\u00e9-Manuel","family":"Ramos-Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6582-7306","authenticated-orcid":false,"given":"Maritza","family":"Calder\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6720-6906","authenticated-orcid":false,"given":"Oralee H.","family":"Branch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2022,9,30]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11908\/5113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11908\/5113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T23:40:02Z","timestamp":1667778002000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/11908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2022.393.11908","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"type":"electronic","value":"1726-4642"},{"type":"print","value":"1726-4634"}],"subject":[],"published":{"date-parts":[[2022,9,30]]}}}