{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:43:52Z","timestamp":1763037832819,"version":"3.40.5"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objetivos. Determinar los factores sociodemogr\u00e1ficos, cl\u00ednicos y radiol\u00f3gicos asociados al tiempo de progresi\u00f3n de discapacidad en pacientes con esclerosis m\u00faltiple (EM). Materiales y m\u00e9todos. Estudio transversal anal\u00edtico, basado en registros de la historia cl\u00ednica de pacientes del Instituto Neurol\u00f3gico de Colombia, entre el 2013 y 2021. La progresi\u00f3n a discapacidad de los pacientes con EM se defini\u00f3 como el tiempo hasta un aumento de por lo menos 0,5 puntos en el valor de la EDSS (del ingl\u00e9s Expanded Disability Status Scale), sostenido por al menos seis meses. Se us\u00f3 un modelo de regresi\u00f3n de Cox para estimar la funci\u00f3n de supervivencia y los hazard ratios (HR) con sus intervalos de confianza de 95% (IC 95%). Resultados. Se incluyeron 216 pacientes, de los cuales el 25% progres\u00f3 a discapacidad, la mediana de supervivencia fue de 78 meses (RIC 95%: 70\u221283), las lesiones activas (HR = 1,94; IC 95%: 1,10\u22123,44), el sexo masculino (HR = 2,5; IC 95%: 1,32\u22124,73), y las enfermedades neurol\u00f3gicas (HR = 2,18; IC95%: 1,03\u22124,61) se asociaron en el modelo multivariado. Conclusiones. La mediana de tiempo de progresi\u00f3n hacia la discapacidad fue de 72 meses. Las lesiones activas captadas en resonancia magn\u00e9tica y el sexo masculino se asociaron con mayor progresi\u00f3n de la discapacidad, con resultados estad\u00edsticamente significativos en el modelo multivariado.\u00a0<\/jats:p>","DOI":"10.17843\/rpmesp.2022.394.11433","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T13:55:15Z","timestamp":1673272515000},"page":"442-49","source":"Crossref","is-referenced-by-count":1,"title":["Factores asociados con el tiempo de progresi\u00f3n de la discapacidad en pacientes con esclerosis m\u00faltiple"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-1169","authenticated-orcid":false,"given":"Anibal","family":"Arteaga-Noriega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9049-0271","authenticated-orcid":false,"given":"John Fredy","family":"Castro-\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-2219","authenticated-orcid":false,"given":"Dione","family":"Benjumea-Bedoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9875-8789","authenticated-orcid":false,"given":"Johanna","family":"Guti\u00e9rrez-Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0010-1413","authenticated-orcid":false,"given":"Angela","family":"Segura-Cardona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0175-2613","authenticated-orcid":false,"given":"Difariney","family":"Gonz\u00e1lez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3493-2872","authenticated-orcid":false,"given":"Jos\u00e9","family":"Zapata-Berruecos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2022,12,26]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11433\/5186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11433\/5186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T13:55:24Z","timestamp":1673272524000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/11433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2022.394.11433","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"type":"electronic","value":"1726-4642"},{"type":"print","value":"1726-4634"}],"subject":[],"published":{"date-parts":[[2022,12,26]]}}}