{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:36:32Z","timestamp":1747200992396,"version":"3.40.5"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Se presenta un caso de leishmaniasis selv\u00e1tica cut\u00e1nea diseminada con manifestaci\u00f3n extensa en unapaciente pedi\u00e1trica con s\u00edndrome de Down. El caso se confirm\u00f3 a trav\u00e9s de estudios parasitol\u00f3gicos einmunol\u00f3gicos, mientras que la identificaci\u00f3n se realiz\u00f3 mediante la t\u00e9cnica de reacci\u00f3n en cadena dela polimerasa-polimorfismos de longitud de fragmentos de restricci\u00f3n (PCR-RFLP, por sus siglas eningl\u00e9s), determin\u00e1ndose la especie como Leishmania (Viannia) braziliensis. La manifestaci\u00f3n cl\u00ednicaagresiva y prolongada con poca respuesta a estibogluconato y anfotericina desoxicolato pueden deberseal d\u00e9ficit inmunol\u00f3gico que se presenta como parte del s\u00edndrome de Down. La paciente eventualmenterecibi\u00f3 tratamiento con anfotericina B liposomal y al t\u00e9rmino de la terapia, mostr\u00f3 mejor\u00eda cl\u00ednica de las lesiones. El presente reporte ilustra los desaf\u00edos tanto de diagn\u00f3stico como tratamiento de leishmaniasis cut\u00e1nea en pacientes pedi\u00e1tricos inmunosuprimidos, especialmente en un entorno de dif\u00edcil acceso social, econ\u00f3mico y geogr\u00e1fico, a los servicios de salud. Se recomienda considerar a la leishmaniasis en el diagn\u00f3stico diferencial cuando se atienda ulceras cr\u00f3nicas dermatol\u00f3gicas at\u00edpicas; as\u00ed como tener en cuenta el uso de anfotericina liposomal en pacientes inmunocomprometidos.<\/jats:p>","DOI":"10.17843\/rpmesp.2023.401.11481","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T20:34:55Z","timestamp":1682368495000},"page":"94-8","source":"Crossref","is-referenced-by-count":1,"title":["Uso de anfotericina B liposomal en leishmaniasis cut\u00e1nea diseminada causada por Leishmania braziliensis en un paciente pedi\u00e1trico con s\u00edndrome de Down"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-803X","authenticated-orcid":false,"given":"Aid\u00e9","family":"Sandoval-Ju\u00e1rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1303-3744","authenticated-orcid":false,"given":"Nyshon","family":"Rojas-Palomino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0433-3622","authenticated-orcid":false,"given":"Lenka","family":"Kolevic Roca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-122X","authenticated-orcid":false,"given":"Graciela","family":"Pilares-Barco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1423-4994","authenticated-orcid":false,"given":"Jorge","family":"Cuadros-Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3740-1962","authenticated-orcid":false,"given":"Roger","family":"Araujo-Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2023,3,22]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11481\/5230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11481\/5264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11481\/5230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T20:35:30Z","timestamp":1682368530000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/11481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2023.401.11481","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"type":"electronic","value":"1726-4642"},{"type":"print","value":"1726-4634"}],"subject":[],"published":{"date-parts":[[2023,3,22]]}}}