{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:02:39Z","timestamp":1780048959187,"version":"3.53.1"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Reportamos los dos primeros casos, en Per\u00fa, sobre el uso del tratamiento con oxigeno hiperb\u00e1rico coadyuvante (TOHC) en pacientes con mucormicosis asociado a COVID-19 (MAC). El primer caso es una mujer de 41 a\u00f1os, con dolor en hemicara y regi\u00f3n palatina izquierdas con rinorrea purulenta de un mes de evoluci\u00f3n. Al examen f\u00edsico, solo evidencia f\u00edstula oroantral. El segundo caso se trata de un var\u00f3n de 35 a\u00f1os, con disminuci\u00f3n de agudeza visual izquierda y dolor palatino con f\u00edstula que drena secreci\u00f3n purulenta de cuatro meses de evoluci\u00f3n. Ambos pacientes tienen el antecedente de diabetes, tuvieron COVID-19 moderado cuatro meses antes del ingreso, y recibieron corticoterapia por este diagn\u00f3stico. Ambos pacientes tuvieron una evaluaci\u00f3n tomogr\u00e1fica que mostr\u00f3 compromiso del seno maxilar y tejido \u00f3seo circundante, con endoscopia nasal diagn\u00f3stica y terap\u00e9utica para desbridamiento. Se obtuvieron muestras compatibles con mucormicosis en estudio histol\u00f3gico. Los pacientes fueron tratados con limpieza quir\u00fargica y anfotericina B desoxicolato, sin embargo, presentaron evoluciones t\u00f3rpidas. Por lo tanto, se adicion\u00f3 la TOHC y mostraron una mejor\u00eda evidente tras cuatro semanas de tratamiento con controles subsiguientes sin presencia de mucormicosis. Resaltamos la evoluci\u00f3n de estos pacientes con TOHC, en una enfermedad con importante morbimortalidad, que ha sido emergente durante la pandemia.<\/jats:p>","DOI":"10.17843\/rpmesp.2023.401.11980","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T20:34:55Z","timestamp":1682368495000},"page":"105-10","source":"Crossref","is-referenced-by-count":4,"title":["Oxigenoterapia hiperb\u00e1rica como tratamiento complementario en mucormicosis asociada a COVID-19: a prop\u00f3sito de dos casos"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-292X","authenticated-orcid":false,"given":"V\u00edctor","family":"Valencia-Caballero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1221-8512","authenticated-orcid":false,"given":"Jos\u00e9","family":"Cachay-Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-0376","authenticated-orcid":false,"given":"Jos\u00e9","family":"Huam\u00e1n-Mu\u00f1ante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7360-4775","authenticated-orcid":false,"given":"Lourdes","family":"Roman\u00ed-Montoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-984X","authenticated-orcid":false,"given":"Norka","family":"V\u00e1squez-Zevallos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9380-5275","authenticated-orcid":false,"given":"C\u00e9sar","family":"Carozzi-Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4550-8655","authenticated-orcid":false,"given":"Cesar","family":"Chian-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1034-0714","authenticated-orcid":false,"given":"Hugo","family":"Hern\u00e1ndez-Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1386-7485","authenticated-orcid":false,"given":"Cristhian","family":"Agust\u00edn-Paredes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7461-5775","authenticated-orcid":false,"given":"Esteban","family":"Vergara-de la Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2023,3,22]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11980\/5231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/11980\/5231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T20:35:26Z","timestamp":1682368526000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/11980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2023.401.11980","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,22]]}}}