{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:35:30Z","timestamp":1787646930621,"version":"build-2736575974"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>La papilomatosis respiratoria recurrente es una enfermedad neopl\u00e1sica causada por el virus del papilomahumano y caracterizada por el crecimiento de lesiones proliferativas exof\u00edticas que afectan la mucosa de las v\u00edas respiratorias. En su epidemiolog\u00eda se presenta una\u00a0 distribuci\u00f3n bimodal, con una forma juvenil en menores de 20 a\u00f1os, m\u00e1s agresiva, con m\u00faltiples lesiones apilomatosas y alta frecuencia de recurrencia, en comparaci\u00f3n con la forma adulta. El compromiso pulmonar es poco frecuente y su manejo es un desaf\u00edo. Se presenta el caso de un var\u00f3n\u00a0 de 13 a\u00f1os con antecedente de papilomatosis lar\u00edngea\u00a0 desde los dos a\u00f1os. El paciente mostr\u00f3 dificultad respiratoria y m\u00faltiples n\u00f3dulos estenosantes en laringe y tr\u00e1quea, y varios quistes pulmonares visualizados en la tomograf\u00eda de t\u00f3rax. Se le realiz\u00f3 ex\u00e9resis de las lesionespapilomatosas y traqueostom\u00eda. Recibi\u00f3 dosis \u00fanica de bevacizumab 400 mg intravenoso y terapias respiratoriascon evoluci\u00f3n favorable, sin recurrencias en el seguimiento.<\/jats:p>","DOI":"10.17843\/rpmesp.2023.401.12169","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T20:34:55Z","timestamp":1682368495000},"page":"111-4","source":"Crossref","is-referenced-by-count":4,"title":["Papilomatosis lar\u00edngea recurrente con compromiso pulmonar: reporte de caso"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-8509","authenticated-orcid":false,"given":"Enrique","family":"Zumaeta-Saavedra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6547-9882","authenticated-orcid":false,"given":"Christian","family":"Chiara-Chilet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-8343","authenticated-orcid":false,"given":"Julio","family":"Maquera-Afaray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-7877","authenticated-orcid":false,"given":"Medalit","family":"Luna-Vilchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2023,3,24]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/12169\/5232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/12169\/5232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T20:35:21Z","timestamp":1682368521000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/12169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2023.401.12169","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,24]]}}}