{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:14:24Z","timestamp":1768684464667,"version":"3.49.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>El presente estudio se plante\u00f3 determinar el rendimiento de ant\u00edgenos de Leishmania braziliensis y Leishmania peruviana en la detecci\u00f3n de LTA, fue desarrollado a partir de muestras de suero obtenidas entre 2013 - 2016. Los ant\u00edgenos solubles y de excreci\u00f3n\/secreci\u00f3n obtenidos fueron transferidos a membrana de nitrocelulosa mediante un ensayo de inmunotransferencia. Se realiz\u00f3 la evaluaci\u00f3n frente a sueros confirmados para LTA, a un nivel de confianza al 95%, logrando determinar que, el ant\u00edgeno soluble de Leishmania braziliensis presenta una sensibilidad del\u00a0 87,7%, especificidad del 100% y \u00e1rea bajo la curva de 0,95; mientras que, Leishmania peruviana se encontr\u00f3 valores de 92,3%, 95,7% y 0,94 respectivamente. De acuerdo a los resultados, recomendamos realizar lacaracterizaci\u00f3n y an\u00e1lisis de las regiones inmunog\u00e9nicas reportadas a fin de continuar con el desarrollo de prote\u00ednas recombinantes y sint\u00e9ticas, orientadas a mejorar la eficiencia del diagn\u00f3stico serol\u00f3gico de la enfermedad.<\/jats:p>","DOI":"10.17843\/rpmesp.2024.413.13231","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T18:17:34Z","timestamp":1726078654000},"page":"294-300","source":"Crossref","is-referenced-by-count":2,"title":["Rendimiento diagn\u00f3stico de los ant\u00edgenos de &lt;i&gt;Leishmania braziliensis&lt;\/i&gt; y &lt;i&gt;Leishmania peruviana&lt;\/i&gt; en el m\u00e9todo de inmunoblot para la detecci\u00f3n de la leishmaniasis tegumentaria americana","Diagnostic performance of &lt;i&gt;Leishmania braziliensis&lt;\/i&gt; and &lt;i&gt;Leishmania peruviana&lt;\/i&gt; antigens in the immunoblot method for the detection of american tegumentary leishmaniasis"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1303-3744","authenticated-orcid":false,"given":"Nyshon","family":"Rojas-Palomino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-803X","authenticated-orcid":false,"given":"Aid\u00e9","family":"Sandoval-Juarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-088X","authenticated-orcid":false,"given":"Gilmer","family":"Solis-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-9568","authenticated-orcid":false,"given":"Gloria","family":"Minaya-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2024,9,3]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/13231\/5653","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/13231\/5653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T18:17:49Z","timestamp":1726078669000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/13231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2024.413.13231","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,3]]}}}