{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:11:44Z","timestamp":1772007104317,"version":"3.50.1"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>The clinical and microbiological characteristics of pneumococcal pneumonia in children hospitalized in Lima were analyzed, before and after the introduction of\u00a0 pneumococcal conjugate vaccines (PCV). We reviewed\u00a0 cases that occurred between 2006-2019, in the pre-PCV7\u00a0 (2006-2008), post-PCV7 (2009-2011) and post-PCV13\u00a0 (2016-2019) periods. Of 128 patients with positive\u00a0 cultures (92 blood and 36 pleural fluid), most\u00a0 were\u00a0 infants in the pre-PCV7 (77.1%) and post-PCV7 (43.3%)\u00a0 studies, while in the post-PCV13 study they were mostly preschoolers (62%). We found an increase in complicated pneumonia cases from 14.6% to 72% and an increase in serotype 19A (6.3% to 68%). The most frequent sequence type was ST320 (31 isolates). Resistance to penicillin and ceftriaxone was low (6% and 2%, respectively), although higher in empyema (21.4% and 14.3%, respectively). Resistance to azithromycin increased from 27% to 92%. Penicillin remains the antibiotic of choice for the treatment of uncomplicated pneumococcal pneumonia in Lima.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.421.13847","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T15:07:10Z","timestamp":1744124830000},"page":"63-9","source":"Crossref","is-referenced-by-count":2,"title":["Caracteri\u0301sticas cli\u0301nicas y microbiol\u00f3gicas de pacientes pedi\u00e1tricos hospitalizados por neumoni\u0301a neumoco\u0301cica antes y despu\u00e9s de la introducci\u00f3n de las vacunas conjugadas neumoc\u00f3cicas","Clinical and microbiological characteristics of paediatric patients hospitalized for pneumococcal pneumonia before and after the introduction of pneumococcal conjugate vaccines"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4868-9841","authenticated-orcid":false,"given":"Carolina","family":"Gomez Vasquez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3059-6736","authenticated-orcid":false,"given":"Brayan","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1906-9599","authenticated-orcid":false,"given":"Roger","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1352-0606","authenticated-orcid":false,"given":"Francisco","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9158-5562","authenticated-orcid":false,"given":"Eduardo","family":"Chaparro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-0148","authenticated-orcid":false,"given":"Olguita","family":"Del \u00c1guila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2192-6235","authenticated-orcid":false,"given":"Maria","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6696-0116","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Saenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1433-1859","authenticated-orcid":false,"given":"Isabel","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3227-3906","authenticated-orcid":false,"given":"Theresa","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2025,3,12]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/13847\/5827","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/13847\/5827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T15:07:14Z","timestamp":1744124834000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/13847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.421.13847","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,12]]}}}