{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:12:15Z","timestamp":1752282735899,"version":"3.40.3"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>La vildagliptina, un inhibidor de la dipeptidil peptidasa-4 (DPP-4i) utilizado en el tratamiento de la diabetes mellitus tipo\u00a0 2 (DM2), se destaca por su seguridad en\u00a0 adultos mayores. Sin embargo, se asocia\u00a0 con reacciones adversas, como el\u00a0 penfigoide ampollar (PA), aunque hasta el\u00a0 momento no se han documentado casos\u00a0 en Per\u00fa. Se reporta un paciente var\u00f3n de 76 a\u00f1os con hipertensi\u00f3n y DM2 que inici\u00f3 tratamiento con vildagliptina y metformina. Despu\u00e9s de un mes, present\u00f3 lesiones cut\u00e1neas pruriginosas, ampollosas y ulceradas, conduciendo al diagn\u00f3stico de PA. El PA, asociado a DPP-4i, afecta principalmente a adultos mayores, manifest\u00e1ndose en promedio unos 9 meses despu\u00e9s del inicio del tratamiento. Su diagn\u00f3stico se basa en criterios cl\u00ednicos, histopatolog\u00eda e inmunofluorescencia. El tratamiento incluye la suspensi\u00f3n del f\u00e1rmaco y el uso de corticoides. La vildagliptina, aunque segura y efectiva, puede provocar PA, que requiere un diagn\u00f3stico y tratamiento oportuno debido a su alta mortalidad.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.421.13871","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T15:07:10Z","timestamp":1744124830000},"page":"97-101","source":"Crossref","is-referenced-by-count":1,"title":["Penfigoide bulloso asociado a vildagliptina en adulto mayor con diabetes mellitus: Primer caso en Per\u00fa","Bullous pemphigoid associated with vildagliptin in an elderly adult with diabetes mellitus: First case in Peru"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-095X","authenticated-orcid":false,"given":"Juan Eduardo","family":"Quiroz-Aldave","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4606-7338","authenticated-orcid":false,"given":"Janet","family":"\u00c1ngeles-Zavaleta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7862-9333","authenticated-orcid":false,"given":"Mar\u00eda del Carmen","family":"Durand-V\u00e1squez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-3727","authenticated-orcid":false,"given":"Jos\u00e9","family":"Paz-Ibarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6928-6144","authenticated-orcid":false,"given":"Janneth Ysabel","family":"Quispe-Meza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-1875","authenticated-orcid":false,"given":"Marcio","family":"Concepci\u00f3n-Zavaleta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-3045","authenticated-orcid":false,"given":"Cristian David","family":"Armas Florez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-3101","authenticated-orcid":false,"given":"Luis Alberto","family":"Concepci\u00f3n-Urteaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2025,2,17]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/13871\/5817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/13871\/5817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T15:07:19Z","timestamp":1744124839000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/13871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.421.13871","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,17]]}}}