{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:24:06Z","timestamp":1787023446238,"version":"build-2736575974"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Reportamos un caso de meningitis por Cryptococcus gattii en un paciente con VIH en la Amazon\u00eda peruana. Paciente var\u00f3n de 36 a\u00f1os, present\u00f3 s\u00edntomas\u00a0 neurol\u00f3gicos severos y fue diagnosticado por cultivo del\u00edquido cefalorraqu\u00eddeo. A pesar de que anfotericina B liposomal y flucitosina son consideradas la terapia antif\u00fangica est\u00e1ndar, ante la falta de recursos se utiliz\u00f3\u00a0 un r\u00e9gimen alterno de anfotericina B desoxicolato y fluconazol, e incluso con ello, el tratamiento enfrent\u00f3\u00a0 desaf\u00edos debido a la persistencia del microorganismo. Este caso resalta la importancia de considerar a C. gattii en el diagn\u00f3stico diferencial de meningitis criptoc\u00f3cica en pacientes inmunodeprimidos, incluso en \u00e1reas\u00a0 donde la prevalencia de este pat\u00f3geno es baja. La efectividad del tratamiento y la supervivencia del\u00a0 paciente destacan la necesidad de estrategias diagn\u00f3sticas y terap\u00e9uticas adaptadas a entornos con recursos limitados.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.422.14195","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T20:00:42Z","timestamp":1757707242000},"page":"212-6","source":"Crossref","is-referenced-by-count":1,"title":["Meningitis por &lt;i&gt;Cryptococcus gattii&lt;\/i&gt; en paciente inmunodeprimido en un Hospital de la Amazon\u00eda peruana: reporte de caso","&lt;i&gt;Cryptococcus gattii&lt;\/i&gt; meningitis in an immunocompromised patient in a hospital in the Peruvian Amazon: case report"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4803-0287","authenticated-orcid":false,"given":"Angel A.","family":"Moreno-Soto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4444-1523","authenticated-orcid":false,"given":"Rodrigo J.","family":"Cardenas-Golac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4999-8495","authenticated-orcid":false,"given":"Marco F.","family":"Paredes-Obando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5175-3457","authenticated-orcid":false,"given":"Jhosephi J.","family":"Vasquez-Ascate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9596-6104","authenticated-orcid":false,"given":"Jorge","family":"Sibina-Vela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-0839","authenticated-orcid":false,"given":"Edgar A.","family":"Ram\u00edrez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2086-2313","authenticated-orcid":false,"given":"Juan C.","family":"Celis-Salinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5972-0948","authenticated-orcid":false,"given":"Wilfredo M.","family":"Casapia-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2025,6,18]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14195\/5880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14195\/5973","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14195\/5882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14195\/5989","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14195\/5880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T20:00:43Z","timestamp":1757707243000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/14195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.422.14195","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,18]]}}}