{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:24:49Z","timestamp":1793316289633,"version":"4.5.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objective. To genetically characterize clinical isolates of uropathogenic Escherichia coli (UPEC) from hospitals in Peru and contextualize them against 127 additional\u00a0 UPEC genomes reported in six Latin American countries between 2018 and 2023. Materials and methods. The genomes of 16 Peruvian UPEC isolates were sequenced, assembled and supplemented with 127 genomes\u00a0 available in the NCBI public database. Serotypes,\u00a0 sequence types (STs), antimicrobial resistance (AMR)\u00a0 genes, and resistance-associated mutations were\u00a0 identified. A phylogenetic analysis was also conducted\u00a0 in order to determine evolutionary relations and distribution in phylogroups. Results. The ST131 cone was the most prevalent (42.7%), followed by ST1193 (13.3%). Phylogroup B2 was widely predominant\u00a0 (83.2%), with serotype O25:H4 standing out. The\u00a0 resistance genes blaTEM-1, blaCTX-M-15, and blaCTX-M-27 were identified with high frequency, as well as mutations in gyrA and parC associated with fluoroquinolone resistance, especially in the ST131 clone. Conclusion. Our findings show high circulation of high-risk UPEC clones, such as ST131 and ST1193, in Latin America, along with a notable burden of genes\u00a0 and mutations linked to multidrug resistance,\u00a0 highlighting the need to strengthen regional genomic surveillance.\n\n\u00a0<\/jats:p>","DOI":"10.17843\/rpmesp.2025.422.14299","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:49:07Z","timestamp":1757706547000},"page":"156-65","source":"Crossref","is-referenced-by-count":8,"title":["Diversidad gen\u00f3mica de &lt;i&gt;Escherichia coli&lt;\/i&gt; uropat\u00f3gena en aislados cl\u00ednicos de seis pa\u00edses de Latinoam\u00e9rica, 2018-2023","Genomic diversity of uropathogenic &lt;i&gt;Escherichia coli&lt;\/i&gt; in clinical isolates from six latin american countries, 2018-2023"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7241-4136","authenticated-orcid":false,"given":"Francesca","family":"Caballero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5271-4319","authenticated-orcid":false,"given":"Anne","family":"Martinez-Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-4614","authenticated-orcid":false,"given":"Diego","family":"Cuicapuza 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