{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:31:56Z","timestamp":1787679116325,"version":"build-2784847793"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Las micosis sist\u00e9micas, como la criptococosis, afectan principalmente los pulmones y el sistema nervioso central; sin embargo, la afectaci\u00f3n de otros \u00f3rganos,\u00a0 como las gl\u00e1ndulas suprarrenales, es poco frecuente. Esto se ha descrito en algunos casos de insuficiencia suprarrenal primaria (ISP) de origen f\u00fangico, los cuales se asocian con una alta mortalidad. Presentamos el\u00a0 caso de un hombre inmunocompetente de 65 a\u00f1os que present\u00f3 manifestaciones cl\u00ednicas de insuficiencia suprarrenal. Las pruebas bioqu\u00edmicas confirmaron ISP, y la tomograf\u00eda abdominal revel\u00f3 hiperplasia de ambas gl\u00e1ndulas suprarrenales, predominantemente en el lado izquierdo. Se realiz\u00f3 una adrenalectom\u00eda izquierda y el examen patol\u00f3gico identific\u00f3 granulomas y estructuras f\u00fangicas compatibles con Cryptococcus\u00a0 spp. El paciente recibi\u00f3 terapia de reemplazo hormonal y tratamiento antif\u00fangico, con una evoluci\u00f3n favorable. La adrenalitis criptoc\u00f3cica debe considerarse en el diagn\u00f3stico diferencial de la ISP, especialmente en presencia de antecedentes epidemiol\u00f3gicos relevantes, y el tratamiento oportuno es clave para mejorar el pron\u00f3stico.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.422.14304","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T21:37:57Z","timestamp":1751665077000},"page":"217-22","source":"Crossref","is-referenced-by-count":2,"title":["Addison\u2019s disease due to adrenal insufficiency in an immunocompetent patient with disseminated cryptococcosis: Case report","Enfermedad de Addison por afectaci\u00f3n suprarrenal en un paciente inmunocompetente con criptococosis diseminada. Reporte de caso"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-3727","authenticated-orcid":false,"given":"Jos\u00e9","family":"Paz-Ibarra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-1875","authenticated-orcid":false,"given":"Marcio","family":"Concepci\u00f3n-Zavaleta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0892-4035","authenticated-orcid":false,"given":"Miguel","family":"Tipiani Mallma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7055-7496","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Delgado-Nicol\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4772-8795","authenticated-orcid":false,"given":"Hilder","family":"Herrera-Silvestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-6407","authenticated-orcid":false,"given":"Laurie","family":"Marcilla-Truyenque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6982-5668","authenticated-orcid":false,"given":"Joseph","family":"Arzapalo-Benavides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-3101","authenticated-orcid":false,"given":"Luis","family":"Concepci\u00f3n-Urteaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2025,6,18]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14304\/5868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14304\/5874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14304\/5874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T21:38:02Z","timestamp":1751665082000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/14304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.422.14304","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,18]]}}}