{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T22:10:07Z","timestamp":1751667007455,"version":"3.41.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>La enfermedad de Alzheimer de inicio precoz (EAIP) representa entre el 5 y 10% de todos los casos de enfermedad de Alzheimer, constituye una forma rara y devastadora de esta condici\u00f3n. Este estudio\u00a0 retrospectivo analiz\u00f3 las historias cl\u00ednicas de pacientes\u00a0 diagnosticados con EAIP entre 2022 y 2023 en un centro neurol\u00f3gico terciario en Lima, Per\u00fa. De 547 casos de\u00a0 demencia, 60 cumpl\u00edan criterios para EAIP. La mayor\u00eda fueron mujeres (73,3%), el 71% ten\u00eda m\u00e1s de seis a\u00f1os\u00a0 de educaci\u00f3n. La media del MMSE fue de 11,92 \u00b1 7,5 y la del CDR fue de 2, indicando deterioro cognitivo severo\u00a0 y demencia moderada. La variante amn\u00e9sica fue la\u00a0 forma cl\u00ednica m\u00e1s com\u00fan, destacando el compromiso\u00a0 de la memoria epis\u00f3dica y la funci\u00f3n ejecutiva. Los\u00a0 s\u00edntomas psicol\u00f3gicos y conductuales m\u00e1s frecuentes\u00a0 fueron la depresi\u00f3n y la irritabilidad. Tambi\u00e9n se identificaron caracter\u00edsticas at\u00edpicas como mioclon\u00edas (5%) y epilepsia (10%). Estos hallazgos destacan la importancia de que los profesionales de salud\u00a0 reconozcan la demencia en adultos j\u00f3venes, en fases tempranas y ofrezcan un manejo integral que mejore la calidad de vida de los pacientes y sus familias.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.422.14413","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T21:37:57Z","timestamp":1751665077000},"page":"196-202","source":"Crossref","is-referenced-by-count":0,"title":["Clinical profile of early-onset Alzheimer\u2019s disease in Peru: case series from a neurological care center","Perfil cl\u00ednico de la enfermedad de Alzheimer de inicio precoz en el Per\u00fa: serie de casos de un centro de atenci\u00f3n neurol\u00f3gica"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0313-3987","authenticated-orcid":false,"given":"Sheila","family":"Castro-Suarez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0497-5270","authenticated-orcid":false,"given":"Jonathan A.","family":"Zegarra-Valdivia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4166-6944","authenticated-orcid":false,"given":"Mar\u00eda","family":"Meza-Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1106-5024","authenticated-orcid":false,"given":"Erik A.","family":"Guevara-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2025,6,18]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14413\/5885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14413\/5886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14413\/5886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T21:38:01Z","timestamp":1751665081000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/14413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.422.14413","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,18]]}}}