{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:20:26Z","timestamp":1788495626804,"version":"build-2803163510"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Objective. To determine mortality and associated factors in patients who received an allogeneic hematopoietic stem cell transplant at the Hospital Nacional Edgardo\u00a0 Rebagliati Martins, between January 2017 and\u00a0 December 2022. Materials and methods. A retrospective cohort study was conducted on patients who underwent allogeneic hematopoietic stem cell transplantation\u00a0 (HSCT) between 2017 and 2022. Death at one hundred\u00a0 days and two years, and its associated factors, were\u00a0 evaluated. Proportional Cox regression models were\u00a0 used. Results. 342 post-HSCT patients were included,\u00a0 with a median age of 23 years (interquartile range: 10 to 39), of whom 53.5% were women. The most frequent\u00a0 diagnosis for the transplant was acute lymphoblastic\u00a0 leukemia at 54.1%. Mortality in the first 100 days post-HSCT was 8.2%, and at two years was 30.4%. In the multivariate regression at one hundred days, factors associated with a higher risk of mortality were age over\u00a0 50 years (HRa: 6.97; 95% CI: 1.18\u221241.23), being a recipient of a haploidentical transplant (HRa: 3.57; 95% CI: 1.13\u221211.24), and sepsis as a complication (HRa: 68.78; 95% CI: 19.32\u2212244.84). In the two-year analysis, acute\u00a0 myeloid leukemia (1.72; IC 95%: 1.08-2.74), haploidentical transplant (HRa:1.81; 95%CI: 1.21-2.72), and disease relapse (HRa: 4.17; 95%CI%: 2.75-6.31) were associated with a higher risk of death. Conclusions. The mortality found was low and similar to that of countries with higher incomes; however, it is necessary to\u00a0 formulate interventions that reduce the incidence of\u00a0 modifiable factors such as sepsis.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.423.14389","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:12:40Z","timestamp":1760037160000},"page":"252-62","source":"Crossref","is-referenced-by-count":1,"title":["Mortalidad y factores asociados en pacientes postrasplante de c\u00e9lulas madre: cohorte de dos a\u00f1os en un hospital p\u00fablico del Per\u00fa","Mortality and associated factors in post-stem cell transplant patients: a two-year cohort in a public hospital in Peru"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1023-0689","authenticated-orcid":false,"given":"Mario","family":"Agramonte-Vilca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1599-462X","authenticated-orcid":false,"given":"Karol","family":"Moscol-Chavez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-1987","authenticated-orcid":false,"given":"Lourdes","family":"Aranda-Gomero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8257-4320","authenticated-orcid":false,"given":"Alfredo","family":"Wong-Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-0638","authenticated-orcid":false,"given":"Stalin","family":"Vilcarromero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3497-0158","authenticated-orcid":false,"given":"Cesar","family":"Copaja-Corzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7920","published-online":{"date-parts":[[2025,9,2]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14389\/5993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14389\/6020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14389\/5993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:12:41Z","timestamp":1760037161000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/14389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.423.14389","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,2]]}}}