{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:28:23Z","timestamp":1766413703600,"version":"3.48.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Se presenta el caso de un var\u00f3n de 28 a\u00f1os con diarrea, cefalea y p\u00e9rdida de peso significativa. Fue diagnosticado con VIH en estadio SIDA (CD4: 3 c\u00e9lulas\/\u03bcL), meningoencefalitis por Cryptococcus neoformans y tuberculosis multisist\u00e9mica. Ante la persistencia de diarrea y estudios coproparasitol\u00f3gicos negativos, se\u00a0 realizaron estudios endosc\u00f3picos. La endoscopia\u00a0 digestiva alta mostr\u00f3 incidentalmente erosiones esof\u00e1gicas recubiertas de fibrina y \u00falceras en sacabocados, estos hallazgos fueron identificados como esofagitis herp\u00e9tica mediante an\u00e1lisis histopatol\u00f3gico e inmunohistoqu\u00edmico. Se inici\u00f3 tratamiento con aciclovir por v\u00eda intravenosa, seguido de administraci\u00f3n oral durante 14 d\u00edas. Este caso resalta la importancia de\u00a0 considerar la esofagitis herp\u00e9tica en pacientes inmunosuprimidos, incluso en ausencia de s\u00edntomas\u00a0 esof\u00e1gicos, y destaca el valor de la endoscopia digestiva alta con toma de biopsia en el diagn\u00f3stico integral del VIH\/SIDA.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.424.14674","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:48Z","timestamp":1766413428000},"page":"436-41","source":"Crossref","is-referenced-by-count":0,"title":["Herpes simplex virus esophagitis in an immunocompromised patient: case report of an atypical presentation","Esofagitis por virus del herpes simple en un paciente inmunocomprometido: reporte de caso de una\u00a0 presentaci\u00f3n at\u00edpica"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4663-7918","authenticated-orcid":false,"given":"Gonzalo David","family":"Layza-Reyes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5743-7473","authenticated-orcid":false,"given":"Camila Milagros","family":"Le\u00f3n-Mej\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6233-0089","authenticated-orcid":false,"given":"Eloy Maier","family":"Valencia Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-8609","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Villalva Luna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-5072","authenticated-orcid":false,"given":"Gustavo","family":"Quispe-Villegas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7710-0662","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Bellido-Capar\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2025,11,21]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14674\/6035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14674\/6045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14674\/6045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:54Z","timestamp":1766413434000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/14674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.424.14674","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,21]]}}}