{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:28:22Z","timestamp":1766413702943,"version":"3.48.0"},"reference-count":0,"publisher":"Instituto Nacional de Salud (Peru)","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Peru Med Exp Salud Publica"],"abstract":"<jats:p>Luego de la introducci\u00f3n de la vacuna Hib (Haemophilus influenzae tipo b) disminuy\u00f3 marcadamente la infecci\u00f3n invasiva por esta bacteria, sin embargo, aument\u00f3 la preocupaci\u00f3n por las otras cepas tipificables y no tipificables (NTHi). La colonizaci\u00f3n previa con este pat\u00f3geno puede convertirse en una fuente de infecci\u00f3n invasiva. Este estudio tuvo como objetivo determinar la colonizaci\u00f3n por H. influenzae en 888 ni\u00f1os sanos menores de 24 meses de edad. La colonizaci\u00f3n fue 4,1% (37 muestras) mediante m\u00e9todos moleculares (todas NTHi) y 1,1% (10 aislamientos) por cultivo (8\/10 biotipo I y 2\/10 biotipo IV). El antecedente de prematuridad se asoci\u00f3 con una mayor colonizaci\u00f3n en el an\u00e1lisis multivariado. De los aislamientos, 9\/10 fueron resistentes a sulfametoxazol\/trimetoprima, 3\/10 a ampicilina y cefuroxima, 2\/10 a azitromicina, y no se observ\u00f3 resistencia a ceftriaxona. Conocer el estado de portaci\u00f3n de H. influenzae y los patrones locales de resistencia es de utilidad para la terapia antibi\u00f3tica emp\u00edrica en infecciones invasivas en las que se sospecha esta bacteria.<\/jats:p>","DOI":"10.17843\/rpmesp.2025.424.14767","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:48Z","timestamp":1766413428000},"page":"416-23","source":"Crossref","is-referenced-by-count":0,"title":["Distribuci\u00f3n de serotipos, biotipo y sensibilidad antibi\u00f3tica de &lt;i&gt;Haemophilus influenzae&lt;\/i&gt; en ni\u00f1os portadores nasofar\u00edngeos en Lima, Per\u00fa","Distribution of serotypes, biotype, and antibiotic sensitivity of &lt;i&gt;Haemophilus influenzae&lt;\/i&gt; in nasopharyngeal carrier children in Lima, Peru"],"prefix":"10.17843","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3059-6736","authenticated-orcid":false,"given":"Brayan E.","family":"Gonzales Jaimes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-5620","authenticated-orcid":false,"given":"Maria","family":"Pinedo-Bardales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-6239","authenticated-orcid":false,"given":"Marcela","family":"Lopez-Brice\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-3210","authenticated-orcid":false,"given":"Edison A.","family":"Rivera-Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9296-2850","authenticated-orcid":false,"given":"David","family":"Durand Vara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-521X","authenticated-orcid":false,"given":"Erik H.","family":"Mercado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8347-6853","authenticated-orcid":false,"given":"Faviola","family":"Valdivia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3227-3906","authenticated-orcid":false,"given":"Theresa J.","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7920","published-online":{"date-parts":[[2025,11,21]]},"container-title":["Revista Peruana de Medicina Experimental y Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14767\/6034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14767\/6044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/download\/14767\/6034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:23:53Z","timestamp":1766413433000},"score":1,"resource":{"primary":{"URL":"https:\/\/rpmesp.ins.gob.pe\/index.php\/rpmesp\/article\/view\/14767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17843\/rpmesp.2025.424.14767","relation":{},"ISSN":["1726-4642","1726-4634"],"issn-type":[{"value":"1726-4642","type":"electronic"},{"value":"1726-4634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,21]]}}}